Intact proteoglycan is a polyclonal activator of murine B-lymphocytes

1987 ◽  
Vol 15 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Jeffrey N. Siegel ◽  
Charles J. Malemud ◽  
Gary M. Kammer
Keyword(s):  
B Lymphocytes ◽  
Polyclonal Activator

scholarly journals Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes.

1979 ◽  
Vol 149 (3) ◽  
pp. 713-723 ◽  
Author(s):  
G W Goodman ◽  
B M Sultzer
Keyword(s):  
T Cells ◽  
B Lymphocytes ◽  
Antibody Production ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Pokeweed Mitogen ◽  
Human Peripheral Blood Lymphocytes ◽  
Polyclonal Activator ◽  
Better Than

Endotoxin protein (EP) has been shown to be a mitogen and polyclonal activator of human peripheral blood lymphocytes. EP stimulates proliferation of B lymphoyctes in the absence of T cells, and this activation is nonspecific by a number of parameters. Additionally, EP mitogenesis, but not polyclonal activation, is inhibited in the presence of human serum, suggesting that these events are dissociable. In these studies, EP appears to be equivalent to or better than pokeweed mitogen in stimulating nonspecific antibody production in vitro.

Altered Fine Structure of B Lymphocytes Correlated with Defective Terminal Differentiation

1973 ◽  
Vol 31 ◽  
pp. 386-387
Author(s):  
Dale E. Bockman ◽  
L. Y. Frank Wu ◽  
Alexander R. Lawton ◽  
Max D. Cooper
Keyword(s):  
Immune Deficiency ◽  
B Lymphocytes ◽  
Plasma Cells ◽  
Present Report ◽  
Specific Antigen ◽  
Terminal Differentiation ◽  
Second Stage ◽  
Two Stages ◽  
Deficiency Diseases ◽  
Cell Line Generation

B-lymphocytes normally synthesize small amounts of immunoglobulin, some of which is incorporated into the cell membrane where it serves as receptor of antigen. These cells, on contact with specific antigen, proliferate and differentiate to plasma cells which synthesize and secrete large quantities of immunoglobulin. The two stages of differentiation of this cell line (generation of B-lymphocytes and antigen-driven maturation to plasma cells) are clearly separable during ontogeny and in some immune deficiency diseases. The present report describes morphologic aberrations of B-lymphocytes in two diseases in which second stage differentiation is defective.

Expression of CD81, am ligand for hepatitis C virus (HCV) is increased on CD5+ B-lymphocytes but may not be the receptor for internalisation of HCV

2001 ◽  
Vol 120 (5) ◽  
pp. A552-A552
Author(s):  
M CURRY ◽  
T DEIGNAN ◽  
P COSTELLO ◽  
L GOLDENMASON ◽  
M DUFFY ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Lymphocytes

Author response for "Autoreactive B‐Lymphocytes in SLE and RA patients: Isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads"

2019 ◽  
Author(s):  
Raquel la Varga‐Martínez ◽  
Beatriz Rodríguez‐Bayona ◽  
Antonio Campos‐Caro ◽  
Gustavo A Añez ◽  
Fermín Medina‐Varo
Keyword(s):  
B Lymphocytes ◽  
Author Response

Relationship among T- and B-lymphocytes of the peripheral blood and thyroid tissue in patients with Graves' disease

2019 ◽  
Author(s):  
Margarita A Dudina ◽  
Andrey A Savchenko ◽  
Sergey A Dogadin ◽  
Alexandr G Borisov ◽  
Igor V Kudryavcev ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Peripheral Blood ◽  
Thyroid Tissue ◽  
T And B Lymphocytes ◽  
Graves Disease
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