Calcium and capsaicin- induced substance P release from peripheral terminals of primary sensory neurons

1988 ◽  
Vol 22 (1-2) ◽  
pp. 117 ◽  
Author(s):  
C.A. Maggi ◽  
P. Santicioli ◽  
P. Geppetti ◽  
R. Patacchini ◽  
E. Del Bianco ◽  
...  
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Sufentanil, Morphine, Met-enkephalin, and k-Agonist (U-50,488H) Inhibit Substance P Release from Primary Sensory Neurons

1989 ◽  
Vol 70 (4) ◽  
pp. 672-677 ◽  
Author(s):  
H. Ming Chang ◽  
Charles B. Berde ◽  
George G. Holz ◽  
Grieg F. Steward ◽  
Richard M. Kream
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Inhibit Substance ◽  
Substance P Release

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

2000 ◽  
Vol 12 (1) ◽  
pp. 397-399 ◽  
Author(s):  
Marzia Malcangio ◽  
Matt S. Ramer ◽  
Martyn G. Jones ◽  
Stephen B. McMahon
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

MODULATION OF SUBSTANCE P RELEASE IN PRIMARY SENSORY NEURONS BY MISOPROSTOL AND PROSTAGLANDINS

1996 ◽  
Vol 3 (4) ◽  
pp. 276-279 ◽  
Author(s):  
H. M. Chang ◽  
L. Wang ◽  
X. P. Zhang ◽  
R. M. Kream ◽  
E. T.H. Yeh
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis

2001 ◽  
Vol 281 (5) ◽  
pp. G1322-G1328 ◽  
Author(s):  
Jaimie D. Nathan ◽  
Akash A. Patel ◽  
Douglas C. McVey ◽  
Jean E. Thomas ◽  
Veronica Prpic ◽  
...  
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Serum Amylase ◽  
Experimental Pancreatitis ◽  
Vanilloid Receptor ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Vanilloid Receptor 1 ◽  
Neurokinin 1 ◽  
Substance P Release

We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 μg/kg ip) in mice. One group received capsazepine (100 μmol/kg sc), a competitive VR1 antagonist, at 4-h intervals. Neurokinin-1 receptor (NK1R) internalization in acinar cells, used as an index of endogenous SP release, was assessed by immunocytochemical quantification of NK1R endocytosis. The severity of pancreatitis was assessed by measurements of serum amylase, pancreatic myeloperoxidase (MPO) activity, and histological grading. Caerulein administration caused significant elevations in serum amylase and pancreatic MPO activity, produced histological evidence of pancreatitis, and caused a dramatic increase in NK1R endocytosis. Capsazepine treatment significantly reduced the level of NK1R endocytosis, and this was associated with similar reductions in pancreatic MPO activity and histological severity of pancreatitis. These results demonstrate that repeated caerulein stimulation causes experimental pancreatitis that is mediated in part by stimulation of VR1 on primary sensory neurons, resulting in endogenous SP release.

scholarly journals Sensory neurons accelerate reepithelialization through Substance P release in an innervated tissue‐engineered model of skin wound healing.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mathieu Blais ◽  
Lorène Mottier ◽  
Sébastien Cadau ◽  
Rémi Parenteau‐ Bareil ◽  
François Berthod
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Sensory Neurons ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
P Release ◽  
Substance P Release

scholarly journals Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Immunity ◽  
2020 ◽  
Vol 53 (5) ◽  
pp. 1063-1077.e7 ◽  
Author(s):  
Caroline Perner ◽  
Cameron H. Flayer ◽  
Xueping Zhu ◽  
Pamela A. Aderhold ◽  
Zaynah N.A. Dewan ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Substance P ◽  
Sensory Neurons ◽  
P Release ◽  
Type 2 Immune Response ◽  
Dendritic Cell Migration ◽  
Substance P Release
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