scholarly journals Sensory neurons accelerate reepithelialization through Substance P release in an innervated tissue‐engineered model of skin wound healing.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mathieu Blais ◽  
Lorène Mottier ◽  
Sébastien Cadau ◽  
Rémi Parenteau‐ Bareil ◽  
François Berthod
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Sensory Neurons ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
P Release ◽  
Substance P Release

Calcium and capsaicin- induced substance P release from peripheral terminals of primary sensory neurons

1988 ◽  
Vol 22 (1-2) ◽  
pp. 117 ◽  
Author(s):  
C.A. Maggi ◽  
P. Santicioli ◽  
P. Geppetti ◽  
R. Patacchini ◽  
E. Del Bianco ◽  
...  
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Sufentanil, Morphine, Met-enkephalin, and k-Agonist (U-50,488H) Inhibit Substance P Release from Primary Sensory Neurons

1989 ◽  
Vol 70 (4) ◽  
pp. 672-677 ◽  
Author(s):  
H. Ming Chang ◽  
Charles B. Berde ◽  
George G. Holz ◽  
Grieg F. Steward ◽  
Richard M. Kream
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Inhibit Substance ◽  
Substance P Release

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

2000 ◽  
Vol 12 (1) ◽  
pp. 397-399 ◽  
Author(s):  
Marzia Malcangio ◽  
Matt S. Ramer ◽  
Martyn G. Jones ◽  
Stephen B. McMahon
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Immunity ◽  
2020 ◽  
Vol 53 (5) ◽  
pp. 1063-1077.e7 ◽  
Author(s):  
Caroline Perner ◽  
Cameron H. Flayer ◽  
Xueping Zhu ◽  
Pamela A. Aderhold ◽  
Zaynah N.A. Dewan ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Substance P ◽  
Sensory Neurons ◽  
P Release ◽  
Type 2 Immune Response ◽  
Dendritic Cell Migration ◽  
Substance P Release

MODULATION OF SUBSTANCE P RELEASE IN PRIMARY SENSORY NEURONS BY MISOPROSTOL AND PROSTAGLANDINS

1996 ◽  
Vol 3 (4) ◽  
pp. 276-279 ◽  
Author(s):  
H. M. Chang ◽  
L. Wang ◽  
X. P. Zhang ◽  
R. M. Kream ◽  
E. T.H. Yeh
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Neuropeptide Substance P Enhances Skin Wound Healing In Vitro and In Vivo under Hypoxia

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 222
Author(s):  
Suneel Kumar ◽  
Yuying Tan ◽  
Francois Berthiaume
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Substance P ◽  
Wound Closure ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Male And Female ◽  
Low Serum

Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP). Previous studies indicate that disturbance in cutaneous sensory innervation leads to a defect in all stages of wound healing, as is the case after SCI. It is hypothesized that nerve fibers enhance wound healing by promoting initial inflammation via the releasing of neuropeptides such as SP. Therefore, we investigated whether exogenous SP improves skin wound healing using in vitro and in vivo models. For in vitro studies, the effects of SP on keratinocyte proliferation and wound closure after a scratch injury were studied under normoxia (pO2 ~21%) or hypoxia (pO2 ~1%) and in presence of normal serum (10% v/v) or low serum (1% v/v) concentrations. Hypoxia and low serum both significantly slowed cell proliferation and wound closure. Under combined low serum and hypoxia, used to mimic the nutrient- and oxygen-poor environment of chronic wounds, SP (10−7 M) significantly enhanced cell proliferation and wound closure rate. For in vivo studies, two full-thickness excisional wounds were created with a 5 mm biopsy punch on the dorsum on either side of the midline of 15-week-old C57BL/6J male and female mice. Immediately, wounds were treated topically with one dose of 0.5 μg SP or PBS vehicle. The data suggest a beneficial role in wound closure and reepithelization, and thus enhanced wound healing, in male and female mice. Taken together, exogenously applied neuropeptide SP enhanced wound healing via cell proliferation and migration in vitro and in vivo. Thus, exogenous SP may be a useful strategy to explore further for treating PUs in SCI and diabetic patients.

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