scholarly journals Insulin-like growth factor binding protein-2, 28 kDa and 24 kDa insulin-like growth factor binding protein levels are decreased in fluid of dominant follicles, obtained from normal and polycystic ovaries

1993 ◽  
Vol 48 (1-2) ◽  
pp. 157-163 ◽  
Author(s):  
A.G.P. Schuller ◽  
D.J. Lindenbergh-Kortleve ◽  
T.D. Pache ◽  
E.C. Zwarthoff ◽  
B.C.J.M. Fauser ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Polycystic Ovaries ◽  
Factor Binding ◽  
Protein Levels

scholarly journals Insulin-Like Growth Factor Binding Protein 6 Is Secreted in Extracellular Vesicles upon Hyperthermia and Oxidative Stress in Dendritic Cells But Not in Monocytes

2020 ◽  
Vol 21 (12) ◽  
pp. 4428
Author(s):  
Massimo Conese ◽  
Lorenzo Pace ◽  
Nicoletta Pignataro ◽  
Lucia Catucci ◽  
Antonio Ambrosi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Growth Factor ◽  
Extracellular Vesicles ◽  
Immune Cells ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Protein Levels ◽  
Inflammatory Stimuli ◽  
And Oxidative Stress

Recently, insulin-like growth factor binding protein 6 (IGFBP-6) has been shown to play a putative role in the immune system, as monocyte-derived dendritic cells (Mo-DCs) are stimulated by hyperthermia to express IGFBP-6 at both the mRNA and protein levels. However, the presence of IGFBP-6 in extracellular vesicles (EVs) and whether other pro-inflammatory stimuli can induce IGFBP-6 expression in Mo-DCs are not known yet. In this brief report, we show that hyperthermia (39 °C) induces IGFBP-6 secretion associated with microvesicles and exosomes as early as 3 h. Moreover, free IGFBP-6 is found in conditioned media (CM) of hyperthermia- and H2O2-treated Mo-DCs, but not in CM obtained from monocytes similarly treated. These results show that diverse inflammatory stimuli can induce IGFBP-6 association with EVs and secretion in conditioned medium, indicating a role for IGFBP-6 in communication between immune cells.

Regulation of insulin-like growth factor-binding protein-1 in rat serum

Diabetes ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M. S. Lewitt ◽  
H. Saunders ◽  
J. L. Phyual ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Rat Serum ◽  
Factor Binding
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