Germ-line transmission of a disrupted β2-microglobulin gene produced by homologous recombination in embryonic stem cells

1990 ◽  
Vol 6 ◽  
pp. 6 ◽  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Germ Line ◽  
Embryonic Stem ◽  
Β2 Microglobulin ◽  
Germ Line Transmission

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells

1990 ◽  
Vol 10 (12) ◽  
pp. 6755-6758
Author(s):  
B R Stanton ◽  
S W Reid ◽  
L F Parada
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Embryonic Development ◽  
Cell Lines ◽  
Germ Line ◽  
Es Cells ◽  
Embryonic Stem ◽  
Es Cell ◽  
Germ Line Transmission

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

scholarly journals Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

1990 ◽  
Vol 10 (12) ◽  
pp. 6755-6758 ◽  
Author(s):  
B R Stanton ◽  
S W Reid ◽  
L F Parada
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Embryonic Development ◽  
Cell Lines ◽  
Germ Line ◽  
Es Cells ◽  
Embryonic Stem ◽  
Es Cell ◽  
Germ Line Transmission

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

Nature ◽  
1989 ◽  
Vol 342 (6248) ◽  
pp. 435-438 ◽  
Author(s):  
Maarten Zijlstra ◽  
En Li ◽  
Fereydoun Sajjadi ◽  
Suresh Subramani ◽  
Rudolf Jaenisch
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Germ Line ◽  
Embryonic Stem ◽  
Germ Line Transmission

scholarly journals Effective Production of Microinjectable Blastocysts for Germ-Line Transmission of Embryonic Stem Cells

2004 ◽  
Vol 53 (5) ◽  
pp. 475-477
Author(s):  
Sun-Uk KIM ◽  
Ying-Hao HAN ◽  
Tae-Hoon LEE ◽  
Byung-Hwa HYUN ◽  
Sang-Ho LEE ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Line ◽  
Embryonic Stem ◽  
Germ Line Transmission

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

Cell ◽  
1989 ◽  
Vol 56 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Simon Thompson ◽  
Alan R. Clarke ◽  
Angela M. Pow ◽  
Martin L. Hooper ◽  
David W. Melton
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Gene Targeting ◽  
Germ Line ◽  
Embryonic Stem ◽  
Hprt Gene ◽  
Germ Line Transmission

scholarly journals The Perfect Host: A Mouse Host Embryo Facilitating More Efficient Germ Line Transmission of Genetically Modified Embryonic Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67826 ◽  
Author(s):  
Robert A. Taft ◽  
Benjamin E. Low ◽  
Shannon L. Byers ◽  
Stephen A. Murray ◽  
Peter Kutny ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Line ◽  
Genetically Modified ◽  
Embryonic Stem ◽  
Germ Line Transmission ◽  
Host Embryo
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