Studies on histaminergic compounds VIII. A new series of compounds showing H1-antagonistic and H2-agonistic properties; synthesis, in vitro pharmacology and structure—activity relationships

Structure Activity ◽

Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles

Journal of Medicinal Chemistry ◽

10.1021/jm00095a021 ◽

1992 ◽

Vol 35 (17) ◽

pp. 3239-3246 ◽

Cited By ~ 70

Author(s):

John C. Eriks ◽

Henk Van der Goot ◽

Geert Jan Sterk ◽

Hendrik Timmerman

Keyword(s):

Histamine H2 Receptor ◽

H2 Receptor ◽

Receptor Agonists ◽

Structure Activity ◽

In Vitro Pharmacology ◽

Qualitative Structure

Synthesis and in vitro pharmacology of a series of new 1,4-dihydropyridines. 2. Diethyl 4-[2-(ω-aminoalkoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates and their corresponding isothioureas as tools for determining structure-activity relationships

European Journal of Medicinal Chemistry ◽

10.1016/0223-5234(93)90048-j ◽

1993 ◽

Vol 28 (12) ◽

pp. 935-941 ◽

Cited By ~ 3

Author(s):

JAM Christiaans ◽

H van der Goot ◽

H Timmerman

Keyword(s):

Structure Activity ◽

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm0400294 ◽

2004 ◽

Vol 47 (18) ◽

pp. 4570-4587 ◽

Cited By ~ 41

Author(s):

Atsuro Nakazato ◽

Kazunari Sakagami ◽

Akito Yasuhara ◽

Hiroshi Ohta ◽

Ryoko Yoshikawa ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Antagonists ◽

Metabotropic Glutamate ◽

Structure Activity ◽

Glutamate Receptor Antagonists ◽

ChemInform Abstract: Selectivity of Sterically Fixed Tryptamine and 5-Methoxytryptamine Derivatives for Serotonin Receptor Subtypes. Part 2. Structure- Activity Relationships and in vitro Pharmacology of N-Alkyl- and N,N- Dialkyl-3-indolylbicyclo-(2.2.1)-

ChemInform ◽

10.1002/chin.199416240 ◽

2010 ◽

Vol 25 (16) ◽

pp. no-no

Author(s):

S. ELZ ◽

H. ZIMMERMANN ◽

K. REHSE

Keyword(s):

Serotonin Receptor ◽

Receptor Subtypes ◽

Structure Activity ◽

Drug Design, in Vitro Pharmacology, and Structure−Activity Relationships of 3-Acylamino-2-aminopropionic Acid Derivatives, a Novel Class of Partial Agonists at the Glycine Site on theN-Methyl-d-aspartate (NMDA) Receptor Complex

Journal of Medicinal Chemistry ◽

10.1021/jm900363q ◽

2009 ◽

Vol 52 (16) ◽

pp. 5093-5107 ◽

Cited By ~ 16

Author(s):

Stephan Urwyler ◽

Philipp Floersheim ◽

Bernard L. Roy ◽

Manuel Koller

Keyword(s):

Nmda Receptor ◽

Drug Design ◽

Receptor Complex ◽

Glycine Site ◽

Partial Agonists ◽

Structure Activity ◽

Nmda Receptor Complex ◽

Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.12.061 ◽

2006 ◽

Vol 14 (10) ◽

pp. 3405-3420 ◽

Cited By ~ 12

Author(s):

Akito Yasuhara ◽

Kazunari Sakagami ◽

Ryoko Yoshikawa ◽

Shigeyuki Chaki ◽

Masato Nakamura ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity ◽

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity ◽

Orally Active

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure–activity relationships (SARs) as antibacterial agent

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.08.010 ◽

2010 ◽

Vol 45 (11) ◽

pp. 5031-5038 ◽

Cited By ~ 21

Author(s):

Mazaahir Kidwai ◽

Roona Poddar ◽

Saurav Bhardwaj ◽

Satendra Singh ◽

Pratibha Mehta Luthra

Keyword(s):

Antibacterial Agent ◽

In Vitro Study ◽

Vitro Study ◽

Structure Activity

Structure-activity relationships of steroids in inducing germinal vesicle breakdown of Atlantic croaker oocytes in vitro

General and Comparative Endocrinology ◽

10.1016/0016-6480(88)90259-6 ◽

1988 ◽

Vol 71 (2) ◽

pp. 307-317 ◽

Cited By ~ 72

Author(s):

John M. Trant ◽

Peter Thomas

Keyword(s):

Germinal Vesicle ◽

Atlantic Croaker ◽

Germinal Vesicle Breakdown ◽

Structure Activity

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum11Abbreviations: CDK, cyclin-dependent kinase; CDK1, cyclin-dependent kinase 1; and PfPK, Plasmodium falciparum protein kinase.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00644-x ◽

2001 ◽

Vol 62 (3) ◽

pp. 341-348 ◽

Cited By ~ 37

Author(s):

Leonie Harmse ◽

Robyn van Zyl ◽

Nathanael Gray ◽

Peter Schultz ◽

Sophie Leclerc ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Protein Kinase ◽

In Vitro Growth ◽

Cyclin Dependent Kinase ◽

Purine Derivatives ◽

Inhibitory Effects ◽

Structure Activity ◽

Falciparum Protein