Effect of oxygen supply on energy metabolism in rats

1994 ◽  
Vol 13 ◽  
pp. 39
Author(s):  
Y. Mimura ◽  
K. Furuya ◽  
J. Maeda ◽  
M. Yamakawa ◽  
T. Oohara
1985 ◽  
Vol 63 (8) ◽  
pp. 903-907 ◽  
Author(s):  
Kanji Nakatsu

The effect of oxygen availability on theophylline metabolism by mouse hepatocytes and rat isolated livers was examined. The elimination of theophylline by mouse hepatocytes and the metabolism of theophylline to dimethyluric acid by isolated, perfused rat livers was seriously impaired when the gas mixture supplied contained less than 28% oxygen. The correlation coefficients relating oxygen supply and the concentration of theophylline remaining in mouse hepatocyte suspensions were −0.74 to −0.84. In the isolated, perfused rat liver experiments, the correlation coefficient relating oxygen availability and dimethyluric acid production was 0.87. These observations are interpreted as supporting the hypothesis that oxygen availability per se is an important factor in determining the rate of theophylline metabolism.


1991 ◽  
Vol 19 (4) ◽  
pp. 354S-354S ◽  
Author(s):  
CESARE BALDUINI ◽  
GLANCARLO DE LUCA ◽  
ALBERTO PASSI ◽  
SIMONETTA RINDI ◽  
ROBERTA SALVINI ◽  
...  

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