Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation

1990 ◽  
Vol 1036 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Susumu Imaoka ◽  
Yoshitaka Yamaguchi ◽  
Yoshihiko Funae
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid ◽  
Rat Renal Microsomes

A novel rat hepatic clofibrate-inducible cytochrome P450 that is not a lauric acid hydroxylase

1991 ◽  
Vol 42 (12) ◽  
pp. 2341-2349 ◽  
Author(s):  
David C. Swinney ◽  
Austin S. Webb ◽  
Richard Freedman
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid

2009 ◽  
Vol 390 (4) ◽  
Author(s):  
Andy Zöllner ◽  
Calin-Aurel Dragan ◽  
Dominik Pistorius ◽  
Rolf Müller ◽  
Helge B. Bode ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fission Yeast ◽  
Lauric Acid ◽  
Myristic Acid ◽  
Poor Prognosis ◽  
Catalytic Properties ◽  
Human Cancer ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Whole Cell Biotransformation

Abstract Overexpression of human CYP4Z1, a cytochrome P450 enzyme, has been correlated with poor prognosis in human cancer. However, its catalytic properties are not yet known. We expressed this P450 in Schizosaccharomyces pombe and demonstrate by whole-cell biotransformation assays CYP4Z1-dependent in-chain hydroxylation of lauric and myristic acid, which in both cases leads to the formation of four different monohydroxylated products at positions ω-2, ω-3, ω-4, and ω-5, respectively. The CYP4Z1-expressing fission yeast should be a new valuable tool for testing cancer drugs or for the development of new prodrug strategies.

scholarly journals 10-Undecynoic acid, an inhibitor of cytochrome P450 4A1, inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes.

1999 ◽  
Vol 46 (1) ◽  
pp. 203-210 ◽  
Author(s):  
J Lenart ◽  
S Pikuła
Keyword(s):  
Endoplasmic Reticulum ◽  
Cytochrome P450 ◽  
Exchange Reaction ◽  
Rat Liver ◽  
Lauric Acid ◽  
Liver Microsomes ◽  
Specific Inhibitor ◽  
Rat Liver Microsomes ◽  
Dependent Manner ◽  
Base Exchange

1,12-Dodecanedioic acid, the end-product of omega-hydroxylation of lauric acid, stimulates in a concentration dependent manner, phosphatidylethanolamine synthesis via ethanolamine-specific phospholipid base exchange reaction in rat liver endoplasmic reticulum. On the other hand, administration to rats of 10-undecynoic acid, a specific inhibitor of omega-hydroxylation reaction catalyzed by cytochrome P450 4A1, inhibits the ethanolamine-specific phospholipid base exchange activity by 30%. This is accompanied by a small but significant decrease in phosphatidylethanolamine content in the endoplasmic reticulum and inhibition of cytochrome P450 4A1. On the basis of these results it can be proposed that a functional relationship between cytochrome P450 4A1 and phosphatidylethanolamine synthesis exists in rat liver. Cytochrome P450 4A1 modulates the cellular level of lauric acid, an inhibitor of phospholipid synthesis. In turn, ethanolamine-specific phospholipid base exchange reaction provides molecular species of phospholipids, containing mainly long-chain polyunsaturated fatty acid moieties, required for the optimal activity of cytochrome P450 4A1.

Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites

2018 ◽  
Vol 112 ◽  
pp. 205-215 ◽  
Author(s):  
Yeon Jung Choi ◽  
Yuanyuan Zhou ◽  
Ji-Yoon Lee ◽  
Chang Seon Ryu ◽  
Young Ho Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid ◽  
Acid Metabolites

scholarly journals Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11

Biochemistry ◽  
2014 ◽  
Vol 53 (39) ◽  
pp. 6161-6172 ◽  
Author(s):  
Donghak Kim ◽  
Gun-Su Cha ◽  
Leslie D. Nagy ◽  
Chul-Ho Yun ◽  
F. Peter Guengerich
Keyword(s):  
Cytochrome P450 ◽  
Kinetic Analysis ◽  
Lauric Acid ◽  
Human Cytochrome ◽  
Acid Hydroxylation

Cloning, Expression in Yeast, and Functional Characterization of CYP76A4, a Novel Cytochrome P450 of Petunia That Catalyzes (ω-1)-Hydroxylation of Lauric Acid

2005 ◽  
Vol 69 (2) ◽  
pp. 406-409 ◽  
Author(s):  
Katsutomo TAMAKI ◽  
Hiromasa IMAISHI ◽  
Hideo OHKAWA ◽  
Kiyoharu OONO ◽  
Mikihiro SUGIMOTO
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid ◽  
Functional Characterization

Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid

1998 ◽  
Vol 110 (1-2) ◽  
pp. 103-121 ◽  
Author(s):  
Xiangming Guan ◽  
Michael B Fisher ◽  
Dieter H Lang ◽  
Yi-Min Zheng ◽  
Dennis R Koop ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid ◽  
Mechanism Of Formation ◽  
Isoform Selectivity

Lauric acid hydroxylase activity and cytochrome P450 IV family proteins in human liver microsomes

1991 ◽  
Vol 42 (9) ◽  
pp. 1841-1844 ◽  
Author(s):  
H.A.A.M. Dlrven ◽  
J.G.P. Peters ◽  
G.Gordon Gibson ◽  
W.H.M. Peters ◽  
F.J. Jongeneelen
Keyword(s):  
Cytochrome P450 ◽  
Lauric Acid ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Hydroxylase Activity
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