Correlations between immediate early gene induction and the persistence of long-term potentiation

Neuroscience ◽  
1993 ◽  
Vol 56 (3) ◽  
pp. 717-727 ◽  
Author(s):  
W.C. Abraham ◽  
S.E. Mason ◽  
J. Demmer ◽  
J.M. Williams ◽  
C.L. Richardson ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Gene Induction ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

Nature ◽  
1993 ◽  
Vol 361 (6411) ◽  
pp. 453-457 ◽  
Author(s):  
Zhuo Qian ◽  
Mary E. Gilbert ◽  
Michael A. Colicos ◽  
Eric R. Kandel ◽  
Dietmar Kuhl
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation ◽  
Tissue Plasminogen

Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus

1992 ◽  
Vol 580 (1-2) ◽  
pp. 147-154 ◽  
Author(s):  
C.L. Richardson ◽  
W.P. Tate ◽  
S.E. Mason ◽  
P.A. Lawlor ◽  
M. Dragunow ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

scholarly journals The immediate early gene Arc is not required for hippocampal long-term potentiation

2021 ◽  
pp. JN-RM-0008-20
Author(s):  
Madeleine Kyrke-Smith ◽  
Lenora J. Volk ◽  
Samuel F. Cooke ◽  
Mark F. Bear ◽  
Richard L. Huganir ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

scholarly journals The immediate early gene Arc is not required for hippocampal long-term potentiation

2020 ◽  
Author(s):  
M. Kyrke-Smith ◽  
L.J. Volk ◽  
S.F. Cooke ◽  
M.F. Bear ◽  
R.L. Huganir ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Memory Storage ◽  
Early Gene ◽  
Immediate Early ◽  
Long Term Memory ◽  
Memory Encoding ◽  
Term Potentiation ◽  
Mrna And Protein Expression

ABSTRACTThe immediate early gene Arc is critical for maintenance of long-term memory. How Arc mediates this process remains unclear, but it has been proposed to sustain Hebbian synaptic potentiation, which is a key component of memory encoding. This form of plasticity is modelled experimentally by induction of long-term potentiation (LTP), which increases Arc mRNA and protein expression. However, mechanistic data implicates Arc in the endocytosis of AMPA-type glutamate receptors and the weakening of synapses. Here, we took a comprehensive approach to determine if Arc is necessary for hippocampal LTP. We find that Arc is not required for LTP maintenance and must regulate memory storage through alternative mechanisms.

scholarly journals Selective increase of functional network connectivity in Arc-positive neuronal engrams after long-term potentiation

2020 ◽  
Author(s):  
Yuheng Jiang ◽  
Antonius M.J. VanDongen
Keyword(s):  
Functional Connectivity ◽  
Hippocampal Neurons ◽  
Network Effects ◽  
Network Connectivity ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Memory Traces ◽  
Term Potentiation ◽  
Memory Engram

ABSTRACTNew tools in optogenetics and molecular biology have culminated in recent studies which mark immediate-early gene (IEG)-expressing neurons as memory traces or engrams. Although the activity-dependent expression of IEGs has been successfully utilised to label memory traces, their roles in engram specification is incompletely understood. Outstanding questions remain as to whether expression of IEGs can interplay with network properties such as functional connectivity and also if neurons expressing different IEGs are functionally distinct. We investigated the expression of Arc and c-Fos, two commonly utilised IEGs in memory engram specification, in cultured hippocampal neurons. After pharmacological induction of long-term potentiation (LTP) in the network, we noted an emergent network property of refinement in functional connectivity between neurons, characterized by a global down-regulation of network connectivity, together with strengthening of specific connections. Subsequently, we show that Arc expression correlates with the effects of network refinement, with Arc-positive neurons being selectively strengthened. Arc positive neurons were also found to be located in closer physical proximity to each other in the network. While the expression pattern of IEGs c-Fos and Arc strongly overlaps, Arc was more selectively expressed than c-Fos. These IEGs also act together in coding information about connection strength pruning. These results demonstrate important links between IEG expression and network connectivity, which serve to bridge the gap between cellular correlates and network effects in learning and memory.

scholarly journals Expression of the Immediate Early Gene c-fos in Basal Ganglia: Induction by Dopaminergic Drugs

1991 ◽  
Vol 18 (S3) ◽  
pp. 380-383 ◽  
Author(s):  
H.A. Robertson ◽  
M.L. Paul ◽  
R. Moratalla ◽  
A.M. Graybiel
Keyword(s):  
Dopamine Agonists ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Dopaminergic Drugs ◽  
Protein Levels ◽  
Selective Antagonists ◽  
Fos Protein ◽  
High Doses

ABSTRACT:Expression of the immediate early gene c-fos is increased in mammalian neurons by a number of stimuli and the usefulness of this gene as a marker of neuronal activation has been demonstrated in several systems. Directlyacting dopamine agonists of the D1-type (SKF 38393, CY 208-243) and indirectly-acting dopamine gonists (amphetamine, cocaine) all produce a rapid and transient increase in Fos protein levels in varying patterns in striatum and cerebral cortex. irectly-acting dopamine agonists only produce c-fos activation in denervated (supersensitive) striatum whereas cocaine and amphetamine activate c-fos in striatum in naive animals. Remarkably, D2 selective antagonists such as haloperidol, albeit in high doses, also activate c-fos expression. Activation of c-fos and other immediate early genes may play a part in the development of such long-term dopamine-related effects as dyskinetic movements and addiction.

scholarly journals Kisspeptin Regulates Gonadotropin Genes via Immediate Early Gene Induction in Pituitary Gonadotropes

2013 ◽  
Vol 27 (8) ◽  
pp. 1283-1294 ◽  
Author(s):  
Emily A. Witham ◽  
Jason D. Meadows ◽  
Hanne M. Hoffmann ◽  
Shadi Shojaei ◽  
Djurdjica Coss ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Gene Induction ◽  
Early Gene ◽  
Immediate Early
Sign in / Sign up

Export Citation Format

Share Document