Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

Nature ◽  
1993 ◽  
Vol 361 (6411) ◽  
pp. 453-457 ◽  
Author(s):  
Zhuo Qian ◽  
Mary E. Gilbert ◽  
Michael A. Colicos ◽  
Eric R. Kandel ◽  
Dietmar Kuhl
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation ◽  
Tissue Plasminogen

Correlations between immediate early gene induction and the persistence of long-term potentiation

Neuroscience ◽  
1993 ◽  
Vol 56 (3) ◽  
pp. 717-727 ◽  
Author(s):  
W.C. Abraham ◽  
S.E. Mason ◽  
J. Demmer ◽  
J.M. Williams ◽  
C.L. Richardson ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Gene Induction ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus

1992 ◽  
Vol 580 (1-2) ◽  
pp. 147-154 ◽  
Author(s):  
C.L. Richardson ◽  
W.P. Tate ◽  
S.E. Mason ◽  
P.A. Lawlor ◽  
M. Dragunow ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

scholarly journals Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

2000 ◽  
Vol 20 (2) ◽  
pp. 542-549 ◽  
Author(s):  
Min Zhuo ◽  
David M. Holtzman ◽  
Yonghe Li ◽  
Hiroshi Osaka ◽  
Joe DeMaro ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Tissue Plasminogen ◽  
Plasminogen Activator Receptor

scholarly journals The immediate early gene Arc is not required for hippocampal long-term potentiation

2021 ◽  
pp. JN-RM-0008-20
Author(s):  
Madeleine Kyrke-Smith ◽  
Lenora J. Volk ◽  
Samuel F. Cooke ◽  
Mark F. Bear ◽  
Richard L. Huganir ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Immediate Early ◽  
Term Potentiation

scholarly journals The immediate early gene Arc is not required for hippocampal long-term potentiation

2020 ◽  
Author(s):  
M. Kyrke-Smith ◽  
L.J. Volk ◽  
S.F. Cooke ◽  
M.F. Bear ◽  
R.L. Huganir ◽  
...  
Keyword(s):  
Immediate Early Gene ◽  
Long Term Potentiation ◽  
Memory Storage ◽  
Early Gene ◽  
Immediate Early ◽  
Long Term Memory ◽  
Memory Encoding ◽  
Term Potentiation ◽  
Mrna And Protein Expression

ABSTRACTThe immediate early gene Arc is critical for maintenance of long-term memory. How Arc mediates this process remains unclear, but it has been proposed to sustain Hebbian synaptic potentiation, which is a key component of memory encoding. This form of plasticity is modelled experimentally by induction of long-term potentiation (LTP), which increases Arc mRNA and protein expression. However, mechanistic data implicates Arc in the endocytosis of AMPA-type glutamate receptors and the weakening of synapses. Here, we took a comprehensive approach to determine if Arc is necessary for hippocampal LTP. We find that Arc is not required for LTP maintenance and must regulate memory storage through alternative mechanisms.

Tissue plasminogen activator is required for corticostriatal long-term potentiation

2002 ◽  
Vol 16 (4) ◽  
pp. 713-721 ◽  
Author(s):  
Diego Centonze ◽  
Maddalena Napolitano ◽  
Emilia Saulle ◽  
Paolo Gubellini ◽  
Barbara Picconi ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Tissue Plasminogen

Abstract TP74: Early Administration of Tissue-plasminogen Activator Improves the Long-term Clinical Outcome at 5 Years After Onset

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Junya Aoki ◽  
Kazumi Kimura ◽  
Yuki Sakamoto
Keyword(s):  
Regression Analysis ◽  
Confidence Interval ◽  
Plasminogen Activator ◽  
Clinical Outcomes ◽  
Tissue Plasminogen Activator ◽  
Odds Ratio ◽  
Univariate Analysis ◽  
Favorable Outcome ◽  
Tissue Plasminogen

Introduction & Hypothesis: Data on long-term outcomes after tissue-plasminogen activator (tPA) therapy are limited. We evaluated the rate of favorable outcomes and mortality at 5 years after tPA therapy and investigated factors related to long-term clinical outcomes. Methods: Telephone interviews were used to assess the to the the modified Rankin Scale (mRS) scores at 3 months, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years after tPA therapy after written informed consent was obtained. When a telephone interview was not successfully accomplished, an interview letter was sent as an alternative method. Favorable outcome was defined as mRS 0-2, and unfavorable outcome was as mRS 3-6. Multivariate logistic regression analysis was conducted to investigate factors associated with favorable outcomes and mortality at 5 years after tPA therapy. Results: From 2005 to 2013, 256 (median age, 77 [interquartile range, 68-84] years; 157 [61%] males) patients were enrolled. The onset-to-treatment time (OTT) was 153 (120-176) minutes. At 3 months after tPA therapy, the median mRS score was assessed as 3 (1-5). Kaplan-Meier curve showed that favorable outcomes after 5 years after tPA therapy occurred in 45% patients and that the mortality rate was 40%. Univariate analysis showed that OTT was 123 (107-172) minutes in patients with favorable outcomes and 155 (124-172) minutes in patients with non-favorable outcomes (p=0.046). In addition, OTT was 157 (133-172) minutes in the death group and 123 (106-169) minutes in the survival group (p=0.001). Multivariate regression analysis indicated that OTT was an independent factor related to favorable outcomes (odds ratio 0.97, 95% confidence interval 0.95-0.99, p=0.008) and mortality (odds ratio 1.04, 95% confidence interval 1.02-1.06, p=0.001). Receiver operating characteristic curve analysis showed that OTT ≥ 136 minutes was the optimal cut-off value to predict favorable outcome at 5 years after tPA therapy, with a sensitivity of 0.67, a specificity of 0.70, and an area under curve (AUC) of 0.662 (p=0.016), and that to predict death within 5 years after tPA therapy, with a sensitivity of 0.70, a specificity of 0.66, and an AUC of 0.679 (p=0.001). Conclusion: Early tPA administration can improves long-term clinical outcomes.

scholarly journals Selective increase of functional network connectivity in Arc-positive neuronal engrams after long-term potentiation

2020 ◽  
Author(s):  
Yuheng Jiang ◽  
Antonius M.J. VanDongen
Keyword(s):  
Functional Connectivity ◽  
Hippocampal Neurons ◽  
Network Effects ◽  
Network Connectivity ◽  
Long Term Potentiation ◽  
Early Gene ◽  
Memory Traces ◽  
Term Potentiation ◽  
Memory Engram

ABSTRACTNew tools in optogenetics and molecular biology have culminated in recent studies which mark immediate-early gene (IEG)-expressing neurons as memory traces or engrams. Although the activity-dependent expression of IEGs has been successfully utilised to label memory traces, their roles in engram specification is incompletely understood. Outstanding questions remain as to whether expression of IEGs can interplay with network properties such as functional connectivity and also if neurons expressing different IEGs are functionally distinct. We investigated the expression of Arc and c-Fos, two commonly utilised IEGs in memory engram specification, in cultured hippocampal neurons. After pharmacological induction of long-term potentiation (LTP) in the network, we noted an emergent network property of refinement in functional connectivity between neurons, characterized by a global down-regulation of network connectivity, together with strengthening of specific connections. Subsequently, we show that Arc expression correlates with the effects of network refinement, with Arc-positive neurons being selectively strengthened. Arc positive neurons were also found to be located in closer physical proximity to each other in the network. While the expression pattern of IEGs c-Fos and Arc strongly overlaps, Arc was more selectively expressed than c-Fos. These IEGs also act together in coding information about connection strength pruning. These results demonstrate important links between IEG expression and network connectivity, which serve to bridge the gap between cellular correlates and network effects in learning and memory.

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