Adjuvant radiation therapy in the treatment of regional lymph node metastases from malignant melanoma: A randomized, prospective study. Preliminary report

A 25-year clinicopathological review of 19 patients with malignant melanoma of the hand is reported. There were 11 women (median age 73 years) and eight men (median age 70 years). Eleven tumours were subungual, six on the dorsum of the hand, and two had a palmar location. Seven tumours were acral lentiginous melanomas, six were superfical spreading melanomas, and five were of the nodular subtype. Eleven patients presented with localized disease (clinical stage I), four with local spread (clinical stage II), and four with regional lymph node metastases (clinical stage III). Nine of the patients have died of the disease, with a median survival time of 30 months (range, 10–84 months). The subungual melanomas were thicker and the patients were older at presentation compared with the non-subungual sites. Review of our patients emphasized the need for early diagnosis.

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Thin regressing malignant melanoma: Significance of concurrent regional lymph node metastases

Histopathology ◽

10.1111/j.1365-2559.1989.tb03076.x ◽

1989 ◽

Vol 15 (3) ◽

pp. 257-265 ◽

Cited By ~ 53

Author(s):

H. M. Shaw ◽

S. W. Mccarthy ◽

W. H. Mccarthy ◽

J. F. Thompson ◽

G. W. Milton

Keyword(s):

Lymph Node ◽

Malignant Melanoma ◽

Lymph Node Metastases ◽

Regional Lymph Node ◽

Node Metastases

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3 Regional lymph node metastases from malignant melanoma

Melanoma Research ◽

10.1097/00008390-199704000-00014 ◽

1997 ◽

Vol 7 (2) ◽

pp. 156

Author(s):

N. Cascinelli ◽

F. Belli

Keyword(s):

Lymph Node ◽

Malignant Melanoma ◽

Lymph Node Metastases ◽

Regional Lymph Node ◽

Node Metastases

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Carcinoid Tumor of the Larynx: Case Report and Review of the World Literature

Otolaryngology ◽

10.1177/019459988609500205 ◽

1986 ◽

Vol 95 (2) ◽

pp. 158-164 ◽

Cited By ~ 15

Author(s):

Carl Snyderman ◽

Jonas T. Johnson ◽

Leon Barnes

Keyword(s):

Radiation Therapy ◽

Case Report ◽

Lymph Node ◽

Carcinoid Tumor ◽

Lymph Node Metastases ◽

World Literature ◽

Regional Lymph Node ◽

Survival Rates ◽

The World ◽

Node Metastases

The clinical, light microscopic, and ultrastructural features of a carcinoid tumor occurring in the larynx of an 80-year-old man are presented and compared with 22 laryngeal carcinoids described in the world literature. These 23 tumors occurred in persons from 45 to 80 years of age (mean age was 61 years) and were three times more common in men than in women. Hoarseness was the most common presenting symptom. Sixty-one percent of the tumors were supraglottic, 26% were transglottic, 4% were glottic, 4% were subglottic, and 4% were unspecified. At least 15 (65%) of the patients are known to have developed metastases. Nine of these (60%) presnted with only regional lymph node metastases, one of which was occult. Surgery is the treatment of choice, with the extent dependent on the stage of disease. Radiation therapy appears ineffective, and chemotherapy is largely untested. The 2- and 4-year determinate survival rates were 59% and 25%, respectively.

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