scholarly journals Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors: A prospectively controlled randomized study by the radiation therapy oncology group

1993 ◽  
Vol 27 ◽  
pp. 155 ◽  
Author(s):  
B. Emami ◽  
C. Scott ◽  
C. Perez ◽  
S. Asbell ◽  
P. Swift ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Randomized Study ◽  
Radiation Therapy Oncology Group ◽  
Human Tumors ◽  
Phase Iii ◽  
Oncology Group ◽  
Interstitial Radiotherapy ◽  
Phase Iii Study ◽  
Radiotherapy Alone

Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma: a radiation therapy oncology group study.

1990 ◽  
Vol 8 (8) ◽  
pp. 1342-1351 ◽  
Author(s):  
M al-Sarraf ◽  
T F Pajak ◽  
J S Cooper ◽  
M Mohiuddin ◽  
A Herskovic ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Side Effects ◽  
Locally Advanced ◽  
Radiation Therapy Oncology Group ◽  
Nasopharyngeal Cancer ◽  
Disease Free Survival ◽  
Stage Iv ◽  
Phase Iii ◽  
Oncology Group ◽  
Radiotherapy Alone

The results of radiotherapy alone for patients with locally advanced (stage III or IV) nasopharyngeal cancer (NPC) are poor in spite of the initial complete clearance. Twenty-seven patients (26 stage IV) were treated with concurrent standard radiotherapy and cisplatin 100 mg/m2 intravenously on day 1 and every 3 weeks for three courses. In 24 (89%) patients, complete response (CR) was achieved. The CR rate was higher for poorly undifferentiated cancer (100%). The major side effects were leukopenia (97%), anemia (54%), nausea and vomiting (81%), stomatitis (92%), and renal impairment (52%). Most of these side effects were either mild or moderate and reversible. All patients finished the radiotherapy dose (greater than 6,450 cGy), 19 (70%) had three courses of cisplatin, and eight had only two courses, six due to drug toxicity. Twenty-six patients with stage IV disease were compared with 78 patients treated with radiotherapy alone by the Radiation Therapy Oncology Group (RTOG). The disease-free survival (DFS), overall survival, and the incidence of distant organ metastasis appear to be better in the combined group. It was concluded that the combination of chemo-radiotherapy in patients with locally advanced NPC needs to be evaluated in a phase III randomized trial.

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