In vitro study drug for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery

1995 ◽  
Vol 126 (1-2) ◽  
pp. 139-145 ◽  
Author(s):  
C Leopold
Keyword(s):  
Drug Delivery ◽  
Aspartic Acid ◽  
Drug Carrier ◽  
In Vitro Study ◽  
Study Drug ◽  
Vitro Study ◽  
Specific Drug ◽  
Colon Specific Drug Delivery

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

scholarly journals SYNTHESIS AND IN VITRO BIODEGRADATION OF AZO POLYMER FOR COLON-SPECIFIC DRUG DELIVERY

2009 ◽  
Vol 007 (1) ◽  
pp. 8-14
Author(s):  
Junying LAI ◽  
Wenjing LI ◽  
Hongjun WANG ◽  
Kehua TU ◽  
Liqun WANG
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
Azo Polymer ◽  
Colon Specific Drug Delivery

Antibody targeting of lipid nanocapsules for directed drug delivery: physico-chemical characterization and in vitro study

2010 ◽  
Vol 15 (23-24) ◽  
pp. 1105-1105
Author(s):  
P. Sánchez-Moreno ◽  
H. Boulaiz ◽  
J.A. Marchal ◽  
J.L. Ortega-Vinuesa ◽  
J.M. Peula García ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Characterization ◽  
In Vitro Study ◽  
Vitro Study ◽  
Lipid Nanocapsules ◽  
Physico Chemical ◽  
Antibody Targeting

scholarly journals Albumin coated liposomes: a novel platform for macrophage specific drug delivery

2011 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Clément Vuarchey ◽  
Sushil Kumar ◽  
Reto Schwendener
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Cell Types ◽  
Specific Drug ◽  
Splenic Macrophages ◽  
Peg Liposomes ◽  
Short Time ◽  
Liposome Surface

Here we report a new and efficient approach of macrophage specific drug delivery by coating liposomes with albumin. Activated albumin was reacted with liposomes containing polyethylene glycol (PEG) as hydrophilic spacers to create a flexible layer of covalently bound albumin molecules on the liposome surface. Albumin coated liposomes were taken up faster and more efficiently than uncoated liposomes by murine macrophages. Liposome uptake was significantly higher in macropha - ges as compared to other cell types tested (endothelial cells, fibroblasts, tumor cells), suggesting specificity for macrophages. In vivo, splenic macrophages phagocytosed BSA coated liposomes (BSA-L) at faster rates compared to conventional liposomes (L) and PEG liposomes (PEG-L). To prove the effectiveness of this new macrophage specific drug carrier, the bisphosphonates clodronate and zoledronate were encapsulated in BSA-L and compared with conventional liposomes. <em>In vitro</em>, treatment of macrophages with clodronate or zoledronate in BSA-L led to cytotoxic activity within a very short time and to up to 50-fold reduced IC50 concentrations. <em>In vivo</em>, clodronate encapsulated in BSA-L depleted splenic macrophages at a 5-fold lower concentration as conventional clodronate-liposomes. Our results highlight the pharmaceutical benefits of albumin-coated liposomes for macrophage specific drug delivery.

Ultrasound-Mediated Targeted Drug Delivery Generated by Multifocal Beam Patterns: An In vitro Study

2013 ◽  
Vol 39 (3) ◽  
pp. 507-514 ◽  
Author(s):  
Dana Gourevich ◽  
Yoni Hertzberg ◽  
Alexander Volovick ◽  
Yaron Shafran ◽  
Gil Navon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Targeted Drug ◽  
Beam Patterns

An Electrochemically Actuated MEMS Device for Individualized Drug Delivery: an In Vitro Study

2013 ◽  
Vol 2 (8) ◽  
pp. 1170-1178 ◽  
Author(s):  
Peiyi Song ◽  
Danny Jian Hang Tng ◽  
Rui Hu ◽  
Guimiao Lin ◽  
Ellis Meng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Mems Device
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