Spin-lattice relaxation and magnetization transfer in intracranial tumors in vivo: Effects of Gd-DTPA on relaxation parameters

1995 ◽  
Vol 13 (3) ◽  
pp. 379-385 ◽  
Author(s):  
Timo Kurki ◽  
Markku Komu
Keyword(s):  
Magnetization Transfer ◽  
Lattice Relaxation ◽  
Spin Lattice Relaxation ◽  
Intracranial Tumors ◽  
Spin Lattice ◽  
Relaxation Parameters ◽  
In Vivo Effects

Saturation transfer in living systems

1980 ◽  
Vol 289 (1037) ◽  
pp. 441-444 ◽  
Keyword(s):  
Magnetization Transfer ◽  
Atp Synthesis ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Living Systems ◽  
Spin Lattice Relaxation ◽  
Synthesis Rate ◽  
Spin Lattice ◽  
Rat Hearts

N.m.r. studies of living systems can be used to obtain kinetic rates in vivo , in addition to providing information about metabolite levels and their time dependences. This is possible through the use of magnetization transfer techniques, which rely on the fact that a nuclear spin will remain in a given quantum state for a period of the order of its spin lattice relaxation time, T 1 , thus enabling perturbation of the nuclear spins in one molecular species and then observation of the transfer of that perturbation to another species, provided that the transfer takes place in a time of the order of T 1 . These times are about 1s in most systems, thus allowing the measurement of rates in the range of 0.1-10 -1 s by this method. These techniques were introduced by Forsen & Hoffman in a series of papers exploring their use in relatively simple chemical systems (Forsen & Hoffman 1963, 1964; Hoffman & Forsen 1969). An early biological application was to cytochrome c, by Gupta & Redfield (1970). The techniques have been applied to Escherichia coli to obtain an ATP synthesis rate (Brown et al . 1977) and to frog muscles and perfused rat hearts to obtain the exchange rates of ATP and phosphocreatine (PCr), this reaction being catalysed by creatine phosphokinase (CPK) in these systems (Brown et al . 1978).

In vivo proton spin-lattice relaxation times of normal and dystrophic muscles

1987 ◽  
Vol 4 (2) ◽  
pp. 153-161 ◽  
Author(s):  
P. A. Narayana ◽  
W. W. Brey ◽  
M. V. Kulkarni ◽  
L. K. Misra
Keyword(s):  
Relaxation Times ◽  
Lattice Relaxation ◽  
Proton Spin ◽  
Spin Lattice Relaxation ◽  
Spin Lattice

scholarly journals Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-d-glucose in normal and ischemic brain

2017 ◽  
Vol 38 (5) ◽  
pp. 869-880 ◽  
Author(s):  
Tao Jin ◽  
Hunter Mehrens ◽  
Ping Wang ◽  
Seong-Gi Kim
Keyword(s):  
Glucose Transport ◽  
Chemical Exchange ◽  
Lattice Relaxation ◽  
Stroke Onset ◽  
Spin Lattice Relaxation ◽  
Spin Lock ◽  
Spin Lattice ◽  
In Vivo Experiments ◽  
Ischemic Core

Glucose transport is important for understanding brain glucose metabolism. We studied glucose transport with a presumably non-toxic and non-metabolizable glucose analog, 3-O-methyl-d-glucose, using a chemical exchange-sensitive spin-lock MRI technique at 9.4 Tesla. 3-O-methyl-d-glucose showed comparable chemical exchange properties with d-glucose and 2-deoxy-d-glucose in phantoms, and higher and lower chemical exchange-sensitive spin-lock sensitivity than Glc and 2-deoxy-d-glucose in in vivo experiments, respectively. The changes of the spin-lattice relaxation rate in the rotating frame (Δ R1ρ) in normal rat brain peaked at ∼15 min after the intravenous injection of 1 g/kg 3-O-methyl-d-glucose and almost maintained a plateau for >1 h. Doses up to 4 g/kg 3-O-methyl-d-glucose were linearly correlated with Δ R1ρ. In rats with focal ischemic stroke, chemical exchange-sensitive spin-lock with 3-O-methyl-d-glucose injection at 1 h after stroke onset showed reduced Δ R1ρ in the ischemic core but higher Δ R1ρ in the peri-core region compared to normal tissue, which progressed into the ischemic core at 3 h after stroke onset. This suggests that the hyper-chemical exchange-sensitive spin-lock region observed at 1 h is the ischemic penumbra at-risk of infarct. In summary, 3-O-methyl-d-glucose-chemical exchange-sensitive spin-lock can be a sensitive MRI technique to probe the glucose transport in normal and ischemic brains.

Constrained modeling for spectroscopic measurement of bi-exponential spin-lattice relaxation of water in vivo

2002 ◽  
Vol 20 (9) ◽  
pp. 681-689 ◽  
Author(s):  
Jack Knight-Scott ◽  
Elana Farace ◽  
Virginia I Simnad ◽  
Helmy M Siragy ◽  
Carol A Manning
Keyword(s):  
Lattice Relaxation ◽  
Spectroscopic Measurement ◽  
Spin Lattice Relaxation ◽  
Spin Lattice
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