scholarly journals Responsiveness of atrial natriuretic factor to reduction in right atrial pressure in patients with chronic congestive heart failure

1988 ◽  
Vol 11 (6) ◽  
pp. 1191-1198 ◽  
Author(s):  
Mark A. Creager ◽  
Alan T. Hirsch ◽  
Elizabeth G. Nabel ◽  
Sally S. Cutler ◽  
Wilson S. Colucci ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Chronic Congestive Heart Failure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Cardiac secretion of atrial natriuretic factor with exercise in chronic congestive heart failure patients

1992 ◽  
Vol 73 (4) ◽  
pp. 1637-1643 ◽  
Author(s):  
R. J. Cody ◽  
S. H. Kubo ◽  
J. H. Laragh ◽  
S. A. Atlas
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Right Ventricular ◽  
Atrial Natriuretic Factor ◽  
Physiological Stress ◽  
Right Atrial ◽  
Peak Exercise ◽  
Chronic Congestive Heart Failure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

We have previously reported a fivefold increase of plasma atrial natriuretic factor (ANF) in patients with congestive heart failure (CHF) compared with normal subjects. However, given the marked increase of ANF under basal conditions, the extent to which ANF secretion can further increase under physiological stress is not been clarified in CHF. We therefore evaluated ANF secretion during ergometric exercise in 11 patients with CHF, with peripheral venous ANF samples obtained at rest and peak exercise. In seven patients, simultaneous peripheral venous and right ventricular ANF samples were obtained to estimate myocardial ANF secretion. Hemodynamic characteristics of exercise included a significant increase of heart rate, mean arterial pressure, and cardiac output (all P < 0.01); reduction of systemic vascular resistance (P < 0.001); and increase of right atrial and pulmonary wedge pressures (P < 0.001). ANF was abnormally elevated at baseline (108 +/- 58 fmol/ml) yet increased further to 183 +/- 86 fmol/ml with exercise (P < 0.003). A step-up of right ventricular ANF, particularly during exercise, was consistent with active myocardial secretion, despite elevated baseline ANF levels.

Atrial dynamics, atrial natriuretic factor, tachycardia, and blood volume in anesthetized rabbits

1991 ◽  
Vol 261 (1) ◽  
pp. H22-H28 ◽  
Author(s):  
K. A. King ◽  
J. R. Ledsome
Keyword(s):  
Blood Volume ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Wall Stress ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Atrial Wall ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

The effects of tachycardia and a slow (1%/min) 20% reduction and elevation of blood volume (BV) on right atrial pressure (RAP), right atrial dimension (RAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) were examined in anesthetized rabbits. Plasma IR-ANF was significantly increased during pacing at 6 Hz in the presence of high BV but not at low BV. Mean RAP increased with expansion of BV, but this change was not associated with significant changes in IR-ANF. There were no statistically significant changes in systolic or diastolic RAD with alterations in BV or with tachycardia. Tachycardia had no effect on left atrial dimension. Diastolic right atrial wall stress (DRAS) and minute DRAS increased with a 20% increase in BV, but changes in BV did not affect systolic right atrial wall stress (SRAS) or minute SRAS. Tachycardia decreased DRAS at high BV and significantly increased SRAS and minute SRAS. The increases in SRAS and minute SRAS were greater during tachycardia at high BV, suggesting that an interaction between BV and tachycardia results in potentiation of SRAS and minute SRAS. The results suggest that systolic RAS is a significant factor in ANF release during tachycardia at high BV.

EVIDENCE FOR FENTANYL ALTERATION OF PLASHA ATRIAL NATRIURETIC FACTOR - RIGHT ATRIAL PRESSURE (RELATIONSHIP AFTEH CARDIAC SURGERY

1986 ◽  
Vol 65 (Supplement 3A) ◽  
pp. A511 ◽  
Author(s):  
D. M. PAYEN ◽  
D. LECLERC ◽  
J. J. CARACO ◽  
I. VIOSSAT ◽  
E. CHABRIER ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Atrial natriuretic factor and right atrial pressure in patients undergoing chronic haemodialysis

1992 ◽  
Vol 29 (3-4) ◽  
pp. 273-277
Author(s):  
G. Tonolo ◽  
V. Scardaccio ◽  
M. La Rocca ◽  
A. Soro ◽  
M. G. Melis ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Chronic Haemodialysis ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Dissociation between right atrial pressure and plasma atrial natriuretic factor following prolonged high salt intake

1990 ◽  
Vol 68 (3) ◽  
pp. 408-412
Author(s):  
Jiri Widimsky Jr. ◽  
Otto Kuchel ◽  
Waldemar Debinski ◽  
Gaétan Thibault
Keyword(s):  
Atrial Natriuretic Factor ◽  
Salt Intake ◽  
High Salt ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Salt Loading ◽  
Natriuretic Factor ◽  
High Salt Intake ◽  
Atrial Natriuretic

The influence of prolonged high salt intake on intravascular volume, right atrial pressure, plasma atrial natriuretic factor, and extra-atrial tissue (lung, kidney, and liver) COOH- and NH2-terminal atrial natriuretic factor content was investigated in normotensive rats. Despite prolonged high salt (8% NaCl) intake for 5 weeks, total intravascular volume was not impaired. However, right atrial pressure was increased by 54% (p < 0.01) after salt loading. Although this increment in right atrial pressure should favor atrial natriuretic factor release after NaCl intake, plasma atrial natriuretic factor (COOH-terminal) concentrations markedly decreased from 97.8 ± 27 to 38.9 ± 8 pg/mL. Sodium and circulatory homeostasis was, however, well preserved. The lungs contained the highest levels of COOH- and NH2-terminal atrial natriuretic factor. Salt loading resulted in increased concentrations of low as well as high molecular weight atrial natriuretic factor in the lung but not in the kidney or the liver. Our study indicates a limited role of atrial natriuretic factor in adaptation to prolonged salt consumption in rats. Dissociation between right atrial pressure and plasma atrial natriuretic factor after salt intake implicates other factors regulating circulating peptide levels. Prolonged salt intake increases lung generation of atrial natriuretic factor.Key words: atrial natriuretic factor, volume, atrial pressure, high salt diet.

Atrial natriuretic factor secretion in dogs with experimental high-output heart failure

1987 ◽  
Vol 252 (4) ◽  
pp. H692-H696 ◽  
Author(s):  
D. Villarreal ◽  
R. H. Freeman ◽  
J. O. Davis ◽  
K. M. Verburg ◽  
R. C. Vari
Keyword(s):  
Heart Failure ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Sodium Balance ◽  
Av Fistula ◽  
Natriuretic Factor ◽  
High Output Heart Failure ◽  
High Output

The temporal changes in the plasma concentration of immunoreactive atrial natriuretic factor (iANF) were studied in six conscious dogs with an arteriovenous (AV) fistula, a model of chronic high-output heart failure. Following the creation of the AV fistula, the dogs retained sodium avidly for 5 days, and plasma renin activity, plasma aldosterone concentration, and right atrial pressure increased significantly from controls. During this initial stage, iANF increased only modestly. From day 6 to 14, the dogs increased their daily sodium excretion and approached sodium balance. This natriuretic response was associated with a significant rise in iANF, with the return of renin and aldosterone levels to base line, and with a progressive significant elevation in right atrial pressure. Thus, in dogs with an AV fistula and cardiac volume overload, chronic increases in atrial pressure appear to be a sustained stimulus for the release of ANF. It is suggested that following the initial period of sodium retention in this experimental mental model of heart failure, chronic endocrine adjustments for the reestablishment of sodium balance involve an increase in ANF which subsequently can exert a tonic inhibitory action on the renin-aldosterone axis. It is concluded that the ANF endocrine system might function as an effective chronic compensatory mechanism to help promote sodium and water excretion in dogs with an AV fistula through the suppression of the renin-aldosterone system and possibly through its direct renal actions.

Atrial natriuretic factor during exercise in patients with congestive heart failure

1988 ◽  
Vol 118 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Niels Keller ◽  
John Larsen ◽  
Roman Sykulski ◽  
Tommy Storm ◽  
Gorm Thamsborg
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Pulmonary Capillary Wedge Pressure ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Natriuretic Factor ◽  
Pulmonary Capillary ◽  
Pulmonary Arterial ◽  
Wedge Pressure ◽  
Atrial Natriuretic

Abstract. In order to evaluate the potential relationship between atrial pressure development and release of atrial natriuretic factor (ANF), 33 patients with congestive heart failure were investigated with rightsided heart catheterization during supine graded bicycle exercise. Resting plasma ANF levels were higher in patients with heart failure as compared with normal controls, 75.1 ± 45.6 pmol/l vs 12.3 ± 6.2 pmol/l (mean ± sd, N = 33 and N = 42, respectively) and correlated with right atrial, pulmonary arterial and pulmonary capillary wedge pressures. During exercise, central pressures rose steeply with a simultaneous increase in plasma ANF in all patients. Plasma ANF levels correlated with heart rate at a workload of 25 w, to pulmonary arterial and pulmonary capillary wedge pressure at 50 w, and to pulmonary capillary wedge pressure at 75 w. The increments in ANF levels between the different workloads during exercise did not correlate with the corresponding increments in pressure values. In congestive heart failure, the capability of ANF secretion in consequence to pressure stimuli is preserved, and left atrial pressure seems to be the major stimulus for ANF release during exercise.

Sign in / Sign up

Export Citation Format

Share Document