Dissociation between right atrial pressure and plasma atrial natriuretic factor following prolonged high salt intake

1990 ◽  
Vol 68 (3) ◽  
pp. 408-412
Author(s):  
Jiri Widimsky Jr. ◽  
Otto Kuchel ◽  
Waldemar Debinski ◽  
Gaétan Thibault
Keyword(s):  
Atrial Natriuretic Factor ◽  
Salt Intake ◽  
High Salt ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Salt Loading ◽  
Natriuretic Factor ◽  
High Salt Intake ◽  
Atrial Natriuretic

The influence of prolonged high salt intake on intravascular volume, right atrial pressure, plasma atrial natriuretic factor, and extra-atrial tissue (lung, kidney, and liver) COOH- and NH2-terminal atrial natriuretic factor content was investigated in normotensive rats. Despite prolonged high salt (8% NaCl) intake for 5 weeks, total intravascular volume was not impaired. However, right atrial pressure was increased by 54% (p < 0.01) after salt loading. Although this increment in right atrial pressure should favor atrial natriuretic factor release after NaCl intake, plasma atrial natriuretic factor (COOH-terminal) concentrations markedly decreased from 97.8 ± 27 to 38.9 ± 8 pg/mL. Sodium and circulatory homeostasis was, however, well preserved. The lungs contained the highest levels of COOH- and NH2-terminal atrial natriuretic factor. Salt loading resulted in increased concentrations of low as well as high molecular weight atrial natriuretic factor in the lung but not in the kidney or the liver. Our study indicates a limited role of atrial natriuretic factor in adaptation to prolonged salt consumption in rats. Dissociation between right atrial pressure and plasma atrial natriuretic factor after salt intake implicates other factors regulating circulating peptide levels. Prolonged salt intake increases lung generation of atrial natriuretic factor.Key words: atrial natriuretic factor, volume, atrial pressure, high salt diet.

Atrial dynamics, atrial natriuretic factor, tachycardia, and blood volume in anesthetized rabbits

1991 ◽  
Vol 261 (1) ◽  
pp. H22-H28 ◽  
Author(s):  
K. A. King ◽  
J. R. Ledsome
Keyword(s):  
Blood Volume ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Wall Stress ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Atrial Wall ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

The effects of tachycardia and a slow (1%/min) 20% reduction and elevation of blood volume (BV) on right atrial pressure (RAP), right atrial dimension (RAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF) were examined in anesthetized rabbits. Plasma IR-ANF was significantly increased during pacing at 6 Hz in the presence of high BV but not at low BV. Mean RAP increased with expansion of BV, but this change was not associated with significant changes in IR-ANF. There were no statistically significant changes in systolic or diastolic RAD with alterations in BV or with tachycardia. Tachycardia had no effect on left atrial dimension. Diastolic right atrial wall stress (DRAS) and minute DRAS increased with a 20% increase in BV, but changes in BV did not affect systolic right atrial wall stress (SRAS) or minute SRAS. Tachycardia decreased DRAS at high BV and significantly increased SRAS and minute SRAS. The increases in SRAS and minute SRAS were greater during tachycardia at high BV, suggesting that an interaction between BV and tachycardia results in potentiation of SRAS and minute SRAS. The results suggest that systolic RAS is a significant factor in ANF release during tachycardia at high BV.

EVIDENCE FOR FENTANYL ALTERATION OF PLASHA ATRIAL NATRIURETIC FACTOR - RIGHT ATRIAL PRESSURE (RELATIONSHIP AFTEH CARDIAC SURGERY

1986 ◽  
Vol 65 (Supplement 3A) ◽  
pp. A511 ◽  
Author(s):  
D. M. PAYEN ◽  
D. LECLERC ◽  
J. J. CARACO ◽  
I. VIOSSAT ◽  
E. CHABRIER ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Atrial natriuretic factor and right atrial pressure in patients undergoing chronic haemodialysis

1992 ◽  
Vol 29 (3-4) ◽  
pp. 273-277
Author(s):  
G. Tonolo ◽  
V. Scardaccio ◽  
M. La Rocca ◽  
A. Soro ◽  
M. G. Melis ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Chronic Haemodialysis ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Effects of repeated increments in right atrial pressure on secretion of atrial natriuretic factor

1988 ◽  
Vol 61 (11) ◽  
pp. 932-934 ◽  
Author(s):  
Mathias C. Haufe ◽  
Jochen Weil ◽  
Rupert Gerzer ◽  
Johanna E. Ernst ◽  
Karl Theisen
Keyword(s):  
Atrial Natriuretic Factor ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Control of atrial natriuretic factor by right and left atrial distension in pregnant sheep

1995 ◽  
Vol 268 (6) ◽  
pp. R1411-R1417
Author(s):  
D. Javeshghani ◽  
S. Mukaddam-Daher ◽  
L. Fan ◽  
Z. Guan ◽  
J. Gutkowska ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Natriuretic Factor ◽  
Pregnant Sheep ◽  
Vascular Catheters ◽  
The Right ◽  
Left Atrial Distension ◽  
Atrial Natriuretic

Previous studies of the atrial stretch-atrial natriuretic factor (ANF) relationship during pregnancy have employed volume expansion and measured only right atrial pressure (RAP). Consequently, we studied nonpregnant (n = 7) and 115- to 125-day pregnant (n = 7) sheep and assessed the ANF response to changes of RAP and left atrial pressure (LAP) induced by graded balloon inflation. Ewes prepared with vascular catheters and atrial balloons were studied after recovery from preparatory surgical procedures. The basal levels of mean arterial pressure (MAP, 83 +/- 3 mmHg), RAP (2.1 +/- 0.7 mmHg), LAP (4.7 +/- 0.9 mmHg), and heart rate (HR, 102 +/- 6 beats/min) were similar in nonpregnant and pregnant sheep. Pregnancy also resulted in elevation of ANF concentration from 25 +/- 6 to 57 +/- 4 fmol/ml. With right atrial distension, the RAP-ANF relationships were similar in both nonpregnant and pregnant sheep, with a 10-mmHg increase in RAP increasing ANF by an average of 95 +/- 9 fmol/ml. In nonpregnant sheep, the LAP-ANF relationship was more responsive than RAP-ANF because a 10-mmHg increase in LAP resulted in a 193 +/- 10 fmol/ml increase in ANF. Moreover, during pregnancy, the LAP-ANF relationship was significantly more sensitive because a 10-mmHg increase in LAP resulted in a 433 +/- 15 fmol/ml elevation of ANF. These data demonstrate that plasma ANF levels are more responsive to distension of the left atria than to the right. More importantly, the ANF response to left, but not right, atrial distension is enhanced by pregnancy.

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