Effects of a new calcium antagonist, mibefradil (Ro 40–5967), on silent ischemia in patients with stable chronic angina pectoris: A multicenter placebo-controlled study

SummaryThe effects of ticlopidine (T) (500 mg daily) on platelet function were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris. The in vitro platelet reactivity to aggregating agents, the platelet sensitivity to prostacyclin and the plasma levels of platelet specific proteins and fibrinogen were determined before and after 4 and 8 weeks of treatment. T exerted a potent inhibitory effect on ADP- and collagen-induced platelet aggregation. The effect of T was proportional to the pretreatment reactivity to ADP and collagen. The inhibitory effect of T on the epinephrine response was less pronounced. The plasma levels of beta-thromboglobulin, platelet factor 4 and fibrinogen were not influenced by T. The platelet inhibition of prostacyclin was potentiated by T, and it was demonstrated that T and prostacyclin had synergistic inhibitory effects on platelet aggregation.

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Antianginal Efficacy of Omapatrilat in Patients With Chronic Angina Pectoris

The American Journal of Cardiology ◽

10.1016/j.amjcard.2005.01.069 ◽

2005 ◽

Vol 95 (11) ◽

pp. 1283-1289 ◽

Cited By ~ 12

Author(s):

Bernard R. Chaitman ◽

Alla Y. Ivleva ◽

Marek Ujda ◽

Jacque H.F. Lenis ◽

Csaba Toth ◽

...

Keyword(s):

Angina Pectoris ◽

Chronic Angina ◽

Antianginal Efficacy

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Pharmacokinetics and additional anti-ischaemic effectiveness of amlodipine, a once-daily calcium antagonist, during acute and long-term therapy of stable angina pectoris in patients pre-treated with a beta-blocker

European Heart Journal ◽

10.1093/eurheartj/14.11.1531 ◽

1993 ◽

Vol 14 (11) ◽

pp. 1531-1535 ◽

Cited By ~ 8

Author(s):

G. LEHMANN ◽

G. REINIGER ◽

A. BEYERLE ◽

W. RUDOLPH

Keyword(s):

Calcium Antagonist ◽

Angina Pectoris ◽

Beta Blocker ◽

Stable Angina ◽

Term Therapy ◽

Stable Angina Pectoris ◽

Once Daily ◽

Long Term Therapy

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Gender Comparison of Efficacy and Safety of Ranolazine for Chronic Angina Pectoris in Four Randomized Clinical Trials

The American Journal of Cardiology ◽

10.1016/j.amjcard.2006.07.052 ◽

2007 ◽

Vol 99 (1) ◽

pp. 11-18 ◽

Cited By ~ 25

Author(s):

Nanette K. Wenger ◽

Bernard Chaitman ◽

George W. Vetrovec

Keyword(s):

Clinical Trials ◽

Angina Pectoris ◽

Randomized Clinical Trials ◽

Efficacy And Safety ◽

Gender Comparison ◽

Chronic Angina

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Angina Pectoris Due to Severe Muscular Bridge in Hypertrophic Cardiomyopathy

Asian Cardiovascular and Thoracic Annals ◽

10.1177/021849239800600215 ◽

1998 ◽

Vol 6 (2) ◽

pp. 132-134

Author(s):

M Şah Topcuoĝlu ◽

Ayhan Usal ◽

Cem Kayhan ◽

Aladdin Pekedis ◽

Acar Tokcan ◽

...

Keyword(s):

Coronary Artery ◽

Calcium Antagonist ◽

Hypertrophic Cardiomyopathy ◽

Angina Pectoris ◽

Left Ventricular Outflow Tract ◽

Young Patients ◽

Ventricular Outflow Tract ◽

Myocardial Scintigraphy ◽

Left Ventricular ◽

Left Ventricular Outflow

We report the case of a 39-year-old male with hypertrophic cardiomyopathy who complained of angina pectoris. The patient was treated with a beta blocker and a calcium antagonist without effect. Myocardial scintigraphy revealed anterior ischemia. Cardiac catheterization and ventriculography revealed severe systolic narrowing of the left anterior descending coronary artery and no significant pressure gradient across the left ventricular outflow tract. Myotomy was performed on a muscular bridge over the left anterior descending coronary artery and the patient's angina was relieved. In young patients with hypertrophic cardiomyopathy who develop angina refractory to medical therapy, a coexisting muscular bridge should be sought.

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