A refined physical map of the long arm of human chromosome 16

Genomics ◽  
1991 ◽  
Vol 10 (2) ◽  
pp. 308-312 ◽  
Author(s):  
L.Z. Chen ◽  
P.C. Harris ◽  
S. Apostolou ◽  
E. Baker ◽  
K. Holman ◽  
...  
Genomics ◽  
1991 ◽  
Vol 10 (4) ◽  
pp. 1047-1052 ◽  
Author(s):  
Robert I. Richards ◽  
Katherine Holman ◽  
Sharon Lane ◽  
Grant R. Sutherland ◽  
David F. Callen

Genomics ◽  
1992 ◽  
Vol 13 (4) ◽  
pp. 1031-1039 ◽  
Author(s):  
Raymond L. Stallings ◽  
Norman A. Doggett ◽  
David Callen ◽  
Sinoula Apostolou ◽  
L.Zhong Chen ◽  
...  

Genomics ◽  
1992 ◽  
Vol 13 (4) ◽  
pp. 1178-1185 ◽  
Author(s):  
D.F. Callen ◽  
N.A. Doggett ◽  
R.L. Stallings ◽  
L.Z. Chen ◽  
S.A. Whitmore ◽  
...  

Genomics ◽  
1994 ◽  
Vol 24 (3) ◽  
pp. 612-613 ◽  
Author(s):  
Steve Gerken ◽  
Kimberlee Fish ◽  
Denise Uyar ◽  
Mihael H. Polymeropoulos ◽  
Paige Bradley ◽  
...  

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 705-712 ◽  
Author(s):  
NP Anagnou ◽  
TY Yuan ◽  
E Lim ◽  
J Helder ◽  
S Wieder ◽  
...  

Abstract In order to test if trans-acting regulatory factors specific for globin genes of the adult and embryonic stages of development exist in erythroid cells, transcriptionally active embryonic and adult globin genes on the same chromosome were transferred by cell fusion from the human leukemia cell K562 into phenotypically adult mouse erythroleukemia cells. Restriction-fragment-length polymorphisms of the K562 zeta (embryonic) globin genes were used to establish that all three copies of human chromosome 16 present in the K562 cell showed the same pattern of human globin gene expression after transfer to the mouse erythroleukemia cell. Adult (alpha) but not embryonic (zeta) human globin mRNA was detected in all nine of the independently derived mouse erythroleukemia hybrid cells, each of which contained human chromosome 16. Restriction endonuclease studies of the K562 alpha- and zeta-globin genes after transfer into the mouse erythroleukemia cell showed no evidence of rearrangements or deletions that could explain this loss of zeta-globin gene expression. These data suggest that regulation of globin gene expression in these erythroleukemia cells involves trans-acting regulatory factors specific for the adult and embryonic stages of development.


1996 ◽  
Vol 72 (4) ◽  
pp. 271-293 ◽  
Author(s):  
Martijn H. Breuning ◽  
Norman A. Doggett ◽  
David F. Callen

Genome ◽  
1997 ◽  
Vol 40 (1) ◽  
pp. 77-83
Author(s):  
R. Bruskiewich ◽  
M. Schertzer ◽  
S. Wood

A number of gene loci, including the locus for Werner syndrome (WRN), map to proximal human chromosome 8p near the genetic marker D8S339. In this report, we present a long range physical map of an approximately 2.8 megabase yeast artificial chromosome contig centred on D8S339. In this map, we localize the WRN-linked polymorphic sequence-tagged sites (STS) D8S339 and D8S1055, as well as a novel polymorphic STS, D8S2297. We also refine the positions of three known gene loci, GTF2E2, GSR, and PPP2CB, relative to the location of WRN within the map.Key words: WRN, GTF2E2, GSR, PPP2CB, physical map, human chromosome 8p.


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