Itaconic acid production using an air-lift bioreactor in repeated batch culture of Aspergillus terreus

1994 ◽  
Vol 77 (3) ◽  
pp. 329-331 ◽  
Author(s):  
Yong Soo Park ◽  
Mitsuru Itida ◽  
Noriyasu Ohta ◽  
Mitsuyasu Okabe
Keyword(s):  
Batch Culture ◽  
Itaconic Acid ◽  
Acid Production ◽  
Aspergillus Terreus ◽  
Repeated Batch Culture ◽  
Repeated Batch ◽  
Air Lift

l(+)-lactic acid production by repeated batch culture of Rhizopus oryzae in air-lift bioreactor

1998 ◽  
Vol 85 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Peimin Yin ◽  
Kazutoyo Yahiro ◽  
Tooru Ishigaki ◽  
Yongsoo Park ◽  
Mitsuyasu Okabe
Keyword(s):  
Lactic Acid ◽  
Batch Culture ◽  
Acid Production ◽  
Rhizopus Oryzae ◽  
Lactic Acid Production ◽  
Repeated Batch Culture ◽  
Repeated Batch ◽  
Air Lift

Repeated-batch culture of immobilizedGibberella fujikuroi B9 for gibberellic acid production: An optimization study

2006 ◽  
Vol 11 (6) ◽  
pp. 544-549 ◽  
Author(s):  
Chang-Joon Kim ◽  
Sang Jong Lee ◽  
Yong Keun Chang ◽  
Gie-Taek Chun ◽  
Yeon-Ho Jeong ◽  
...  
Keyword(s):  
Gibberellic Acid ◽  
Batch Culture ◽  
Acid Production ◽  
Repeated Batch Culture ◽  
Optimization Study ◽  
Repeated Batch

Mathematical modeling of citric acid production by repeated batch culture

2000 ◽  
Vol 26 (9-10) ◽  
pp. 826-833 ◽  
Author(s):  
Tigran E. Arzumanov ◽  
Igor A. Sidorov ◽  
Nadezhda V. Shishkanova ◽  
Tatyana V. Finogenova
Keyword(s):  
Mathematical Modeling ◽  
Citric Acid ◽  
Batch Culture ◽  
Acid Production ◽  
Citric Acid Production ◽  
Repeated Batch Culture ◽  
Repeated Batch

scholarly journals An Optimized Ustilago Chassis for Itaconic Acid Production at Theoretical Maximal Yield

2020 ◽  
Author(s):  
J. Becker ◽  
H. Hosseinpour Tehrani ◽  
P. Ernst ◽  
L. M. Blank ◽  
N. Wierckx
Keyword(s):  
Itaconic Acid ◽  
Acid Production ◽  
Aspergillus Terreus ◽  
Lipid Production ◽  
Ustilago Maydis ◽  
Product Formation ◽  
Fed Batch ◽  
Maximal Yield ◽  
Morphology Engineering ◽  
Continuous Feed

Ustilago maydis, member of the Ustilaginaceae family, is a promising host for the production of several metabolites including itaconic acid. This dicarboxylate has great potential as a bio-based building block in the polymer industry, and is of special interest for pharmaceutical applications. Several itaconate overproducing Ustilago strains have been generated by metabolic and morphology engineering. This yielded stabilized unicellular morphology through fuz7 deletion, reduction of by-product formation through deletion of genes responsible for itaconate oxidation and (glyco)lipid production, and the overexpression of the regulator of the itaconate cluster ria1 and the mitochondrial tricarboxylate transporter encoded by mttA from Aspergillus terreus. In this study, itaconate production was further optimized by consolidating these different optimizations into one strain. The combined modifications resulted in itaconic acid production at theoretical maximal yield, which was achieved under biotechnologically relevant fed-batch fermentations with continuous feed.

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