Lead inhibits 1,25-dihydroxyvitamin D-3 regulation of calcium metabolism in osteoblastic osteosarcoma cells (ROS 17/2.8)

This paper reviews the regulation of calcium metabolism in man. The body's calcium economy is determined by the relationship between the intestinal absorption of calcium, the renal handling of calcium, and by the movements of calcium in and out of the skeleton. These processes are influenced by many factors, the most important of which are parathyroid hormone and the hormones derived from the renal metabolism of vitamin D, notably 1,25-dihydroxyvitamin D8. The role of endogenous calcitonin in man is still controversial, but there are several other hormones which have some influence on calcium metabolism, including thyroid hormone, growth hormone, and the adrenal and gonadal steroids. Clinical disorders of calcium metabolism and their treatment are discussed in terms of the disturbances in normal physiology they represent.

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Effect of 1,10-phenanthroline on DNA binding of 1,25-dihydroxyvitamin D receptors and characterization and regulation of retinoic acid receptors in rat osteosarcoma cells

10.31274/rtd-180813-12141 ◽

1991 ◽

Author(s):

Kevin Brady Atkins

Keyword(s):

Retinoic Acid ◽

Dna Binding ◽

Retinoic Acid Receptors ◽

Osteosarcoma Cells ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D

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Rare Causes of Hypercalcemia

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2005-0675 ◽

2005 ◽

Vol 90 (11) ◽

pp. 6316-6322 ◽

Cited By ~ 131

Author(s):

Thomas P. Jacobs ◽

John P. Bilezikian

Keyword(s):

Primary Hyperparathyroidism ◽

Calcium Metabolism ◽

Clinical Investigation ◽

Evidence Synthesis ◽

Computer Search ◽

Potential Mechanism ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Normal Metabolism ◽

In Infants And Children

Abstract Context: Although hypercalcemia is usually caused by primary hyperparathyroidism or malignancy, a number of other conditions can be important to consider. This review considers unusual causes of hypercalcemia that are generally not found in reviews on this subject. Evidence Acquisition: Articles describing rarely reported associations between hypercalcemia and unusual causes were identified through a computer search of the terms hypercalcemia/etiology and through the references listed in those articles. We grouped the 58 different reports into categories defined by a presumed etiology: increased levels of 1,25-dihydroxyvitamin D or PTHrP, occult milk-alkali syndrome, and undefined mechanisms. Reports in infants and children are listed separately, as are reports of pseudohypercalcemia, situations that are not truly hypercalcemic because the ionized calcium is normal. Evidence Synthesis: In some situations, as this review points out, a number of unusual causes of hypercalcemia are important to consider. The search for an elusive cause of hypercalcemia is best accomplished by the most likely potential mechanism. An orderly search in this manner is likely to reveal the underlying cause. Conclusions: That so many patients have been described with rare and usually poorly understood causes of hypercalcemia highlights our incomplete understanding of calcium metabolism in humans and suggests additional areas in which directed clinical investigation might improve our knowledge of the normal metabolism of calcium.

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