Effect of nicardipine and diltiazem on internal carotid artery blood flow velocity and local cerebral blood flow during cerebral aneurysm surgery for subarachnoid hemorrhage

This study was undertaken to measure the effects of serotonin administration on local cerebral blood flow following blood–brain barrier (BBB) disruption with hypertonic urea. Rats were anesthetized with halothane in nitrous oxide and oxygen (70%:30%). In some animals urea (3.5 M) was infused retrogradely through an external carotid catheter, followed after 10 min by serotonin (50 ng kg−1 min−1) or physiological saline. Local cerebral blood flow was measured using the 14C-iodoantipyrine quantitative autoradiographic technique of Sakurada et al. (1978). The administration of saline or urea alone had only minimal effects on local cerebral blood flow. When the BBB was intact, serotonin produced a significant fall in regional blood flow only in the caudate nucleus. Following BBB disruption, however, serotonin produced a marked decrease in local perfusion in a number of discrete brain areas that are supplied by blood from the internal carotid artery. On the other hand, there were increases in local perfusion in areas not supplied by the internal carotid artery.

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Middle Cerebral Artery Blood Flow Velocity and Stable Xenon-Enhanced Computed Tomographic Blood Flow During Balloon Test Occlusion of the Internal Carotid Artery

Stroke ◽

10.1161/01.str.26.9.1603 ◽

1995 ◽

Vol 26 (9) ◽

pp. 1603-1606 ◽

Cited By ~ 31

Author(s):

W. Andrew Kofke ◽

Patric Brauer ◽

Raymond Policare ◽

Susan Penthany ◽

David Barker ◽

...

Keyword(s):

Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Middle Cerebral Artery ◽

Blood Flow Velocity ◽

Internal Carotid ◽

Artery Blood Flow ◽

Computed Tomographic ◽

Balloon Test Occlusion ◽

Stable Xenon

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Internal Carotid Artery Blood Flow in Pediatric Moyamoya Patients

Case Medical Research ◽

10.31525/ct1-nct04134221 ◽

2019 ◽

Author(s):

Keyword(s):

Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Internal Carotid ◽

Artery Blood Flow

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Impact of transient hypotension on regional cerebral blood flow in humans

Clinical Science ◽

10.1042/cs20140751 ◽

2015 ◽

Vol 129 (2) ◽

pp. 169-178 ◽

Cited By ~ 45

Author(s):

Nia C.S. Lewis ◽

Kurt J. Smith ◽

Anthony R. Bain ◽

Kevin W. Wildfong ◽

Tianne Numan ◽

...

Keyword(s):

Carbon Dioxide ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Vertebral Artery ◽

Regional Cerebral Blood Flow ◽

Internal Carotid ◽

Regional Cerebral Blood

Diameter reductions in the internal carotid artery (ICA) and vertebral artery (VA) contribute to the decline in brain blood with hypotension. The decline in vertebral blood flow with hypotension was greater when carbon dioxide was low; this was not apparent in the ICA.

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Clinical Utility of Quantitative Cerebral Blood Flow Measurements during Internal Carotid Artery Test Occlusions

Neurosurgery ◽

10.1227/00006123-200205000-00012 ◽

2002 ◽

Vol 50 (5) ◽

pp. 996-1005 ◽

Cited By ~ 1

Author(s):

Randolph S. Marshall ◽

Ronald M. Lazar ◽

William L. Young ◽

Robert A. Solomon ◽

Shailendra Joshi ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Clinical Utility ◽

Internal Carotid ◽

Flow Measurements ◽

Blood Flow Measurements

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Dynamic Computed Tomography Angiography in Suspected Brain Death: A Noninvasive Biomarker

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2014.02.002 ◽

2014 ◽

Vol 65 (4) ◽

pp. 352-359 ◽

Cited By ~ 1

Author(s):

Santanu Chakraborty ◽

Reem A. Adas

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Brain Death ◽

Internal Carotid ◽

External Carotid Artery ◽

External Carotid ◽

Ancillary Test ◽

Organ Harvesting

Purpose Neurologic determination of death or brain death is primarily a clinical diagnosis. This must respect all guarantees required by law and should be determined early to avoid unnecessary treatment and allow organ harvesting for transplantation. Ancillary testing is used in situations in which clinical assessment is impossible or confounded by other factors. Our purpose is to determine the utility of dynamic computed tomographic angiography (dCTA) as an ancillary test for diagnosis of brain death. Materials and Methods We retrospectively reviewed 13 consecutive patients with suspected brain death in the intensive care unit who had dCTA. Contrast appearance timings recorded from the dCTA data were compared to findings from 15 controls selected from patients who presented with symptoms of acute stroke but showed no stroke in follow-up imaging. Results The dCTA allows us to reliably assess cerebral blood flow and to record time of individual cerebral vessels opacification. It also helps us to assess the intracranial flow qualitatively against the flow in extracranial vessels as a reference. We compared the time difference between enhancement of the external and internal carotid arteries and branches. In all patients who were brain dead, internal carotid artery enhancement was delayed, which occurred after external carotid artery branches were opacified. Conclusion In patients with suspected brain death, dCTA reliably demonstrated the lack of cerebral blood flow, with extracranial circulation as an internal reference. Our initial results suggest that inversion of time of contrast appearance between internal carotid artery and external carotid artery branches at the skull base could predict a lack of distal intracranial flow.

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