16 The role of external irradiation in early prostate cancer

1995 ◽  
Vol 31 ◽  
pp. S4
Author(s):  
M. Bolla
2020 ◽  
Author(s):  
Pierre Roscher ◽  
Jacqueline M Van Wyk

Abstract Background: Early prostate cancer (PCa) treatment interventions may leave men with debilitating sexual side effects. These side effects may remain permanent, often undiagnosed and undermanaged. The objective of this study is to map the evidence pertaining to the prevalence, and use of questionnaires, related to the neglected sexual side effects (NSSE) after Pca treatment.Methods:This systematic scoping review’s search strategy will involve the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Thescreenings will be guided by the eligibility criteria. Data will be extracted from the included studies and the emerging themes will be analysed. The review team will analyse the implications of the findings in relation to the research question and aim of the study. The Mixed Method Appraisal Tool (MMAT) will be employed for quality appraisal of included studies.Discussion: We anticipate finding a small amount of studies pertaining to the prevalence and questionnaire use for NSSE after early PCa treatment. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations as well as presentations at relevant conferences


2020 ◽  
Author(s):  
Pierre Roscher ◽  
Jacqueline M Van Wyk

Abstract Background: Early prostate cancer (PCa) treatment interventions may leave men with debilitating sexual side effects. These side effects may remain permanent, often undiagnosed and undermanaged. The objective of this study is to map the evidence about the prevalence, and use of questionnaires, related to the neglected sexual side effects (NSSE) after PCa treatment.Methods: This systematic scoping review's search strategy will involve the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Eligibility criteria will guide the screenings. Data will be extracted from the included studies, and the emerging themes will be analysed. The review team will analyse the implications of the findings concerning the research question and aim of the study. The Mixed Method Appraisal Tool (MMAT) will be employed for quality appraisal of included studies.Discussion: We anticipate finding a small number of studies about the prevalence and questionnaire use for NSSE after early PCa treatment. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations, as well as presentations at relevant conferences.


2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Valentina Casadio ◽  
Daniele Calistri ◽  
Samanta Salvi ◽  
Roberta Gunelli ◽  
Elisa Carretta ◽  
...  

Circulating cell-free DNA has been recognized as an accurate marker for the diagnosis of prostate cancer, whereas the role of urine cell-free DNA (UCF DNA) has never been evaluated in this setting. It is known that normal apoptotic cells produce highly fragmented DNA while cancer cells release longer DNA. We thus verified the potential role of UCF DNA integrity for early prostate cancer diagnosis. UCF DNA was isolated from 29 prostate cancer patients and 25 healthy volunteers. Sequences longer than 250 bp (c-Myc,BCAS1, andHER2) were quantified by real-time PCR to verify UCF DNA integrity. Receiver operating characteristic (ROC) curve analysis revealed an area under the curve of 0.7959 (95% CI 0.6729–0.9188). At the best cut-off value of 0.04 ng/μL, UCF DNA integrity analysis showed a sensitivity of 0.79 (95% CI 0.62–0.90) and a specificity of 0.84 (95% CI 0.65–0.94). These preliminary findings indicate that UCF DNA integrity could be a promising noninvasive marker for the early diagnosis of prostate cancer and pave the way for further research into this area.


PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0227031 ◽  
Author(s):  
Ilinca Cosma ◽  
Cornelia Tennstedt-Schenk ◽  
Sven Winzler ◽  
Marios Nikos Psychogios ◽  
Alexander Pfeil ◽  
...  

2015 ◽  
Vol 25 (6) ◽  
pp. 510-517 ◽  
Author(s):  
Mrishta Brizmohun Appayya ◽  
Edward William Johnston ◽  
Shonit Punwani

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