Objective: The aim of this study was to evaluate comparatively the topical and systemic forms in the postoperative pain control periodontal flap surgery in spite of the daily dose of benzydamine hydrochloride spray form about one in twenty of the oral dose,.
Materials and Methods: In this randomized trial, the 48 systemic healthy individuals in need double-blind study with periodontal flap surgery were evaluated. Consent, demographic information and periodontal clinical parameters were obtained before surgery and periodontal flap surgery was performed with local anesthesia. The patients who underwent surgery were randomly assigned to two groups. One of the groups was prescribed tablet form of postopertive benzydamine hydrochloride and for the other was spray form as topical application. Postoperative pain was assessed by visual analog scale at 2, 6, 8, 12, 24 and 48 hours.
Results: There was no difference between systemic and topical drug groups in terms of demographic characteristics and periodontal clinical parameters. A statistically significant difference was found between 2 and 6 hours in favor of topical application. (p <0.05), but there was no significant difference in pain intensity at the 8th, 12th, 24th and 48th hours.
Conclusion: Although the topical form of benzydamine hydrochloride was 1/20 lower in postoperative pain control after periodontal flap surgery, it was found to be more effective in the early period compared to the systemic form, but equally effective in the late period. We premierly recommend that topical application should be preferred primarily in the prevention of overdose and toxicity in postoperative pain control after periodontal flap operation.
Bayesian inference for causal mechanisms with application to a randomized study for postoperative pain control
