Generation of IL-6 receptor antagonist and super-antagonist by molecular modelling and site-directed mutagenesis

Cytokine ◽  
1994 ◽  
Vol 6 (5) ◽  
pp. 556
Author(s):  
C. Toniatti ◽  
A. Lahm ◽  
R. Savino ◽  
A. Cabibbo ◽  
L. Ciapponi ◽  
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Keyword(s):  
Receptor Antagonist ◽  
Molecular Modelling ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

scholarly journals Analysis of structural determinants of the stability of thermolysinlike proteases by molecular modelling and site-directed mutagenesis

1996 ◽  
Vol 9 (12) ◽  
pp. 1181-1189 ◽  
Author(s):  
Oene R. Veltman ◽  
Gert Vriend ◽  
Pieter J. Middelhoven ◽  
Bertus van den Burg ◽  
Gerard Venema ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Structural Determinants ◽  
The Stability

scholarly journals Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling

2002 ◽  
Vol 269 (22) ◽  
pp. 5522-5526 ◽  
Author(s):  
Mónica Salas ◽  
Rolando Rodríguez ◽  
Nelia López ◽  
Elena Uribe ◽  
Vasthi López ◽  
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Keyword(s):  
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Reaction Mechanism ◽  
Molecular Modelling ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

scholarly journals Site-directed Mutagenesis of CC Chemokine Receptor 1 Reveals the Mechanism of Action of UCB 35625, a Small Molecule Chemokine Receptor Antagonist

2004 ◽  
Vol 280 (6) ◽  
pp. 4808-4816 ◽  
Author(s):  
Filipa Lopes de Mendonça ◽  
Paula C. A. da Fonseca ◽  
Rhian M. Phillips ◽  
José W. Saldanha ◽  
Timothy J. Williams ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Small Molecule ◽  
Mechanism Of Action ◽  
Chemokine Receptor ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist ◽  
Chemokine Receptor 1

scholarly journals Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling

2007 ◽  
Vol 8 (1) ◽  
pp. 21 ◽  
Author(s):  
Viet-Lai Pham ◽  
Marie-Sandrine Cadel ◽  
Cecile Gouzy-Darmon ◽  
Chantal Hanquez ◽  
Margery C Beinfeld ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Binding Motif ◽  
Processing Enzyme
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