ALTERED REGULATION OF A HUMAN GENE INDUCED BY IONIZING RADIATION IN TUMOR CELL LINES

Author(s):  
A.J. Fornace ◽  
M.A. Papathanasiou ◽  
M.C. Hollander ◽  
E. Farhangi ◽  
I. Alamo ◽  
...  
Author(s):  
Chris van Bree ◽  
Natasja Castro Kreder ◽  
Willem J.P Loves ◽  
Nicolaas A.P Franken ◽  
Godefridus J Peters ◽  
...  

Gene ◽  
1996 ◽  
Vol 180 (1-2) ◽  
pp. 125-130 ◽  
Author(s):  
Tina Rich ◽  
Pengchin Chen ◽  
Felix Furman ◽  
Nhung Huynh ◽  
Mark A. Israel

1999 ◽  
Vol 86 (3-4) ◽  
pp. 214-218 ◽  
Author(s):  
S. Sabbioni ◽  
A. Veronese ◽  
M. Trubia ◽  
R. Taramelli ◽  
G. Barbanti-Brodano ◽  
...  

Author(s):  
Renato Marchesini ◽  
Ambrogio Colombo ◽  
Claudia Caserini ◽  
Paola Perego ◽  
Rosanna Supino ◽  
...  

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.


1989 ◽  
Vol 1 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Richard D. H. Whelan ◽  
Louise K. Hosking ◽  
Alan J. Townsend ◽  
Kenneth H. Cowan ◽  
Bridget T. Hill

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