Vitreous Anatomy, Aging, and Anomalous Posterior Vitreous Detachment

2010 ◽  
pp. 307-315 ◽  
Author(s):  
J. Sebag

Anomalous posterior vitreous detachment is an important step in the pathogenesis of vitreoretinal interface diseases. In order to understand the pathophysiology of vitreoretinal interface diseases, the structure and biochemistry of the vitreous body, and its relation with the retina should be investigated. Having a clear understanding of the pathophysiology of these diseases may help to develop new pharmacologic or surgical treatment modalities.


2019 ◽  
Vol 24 (41) ◽  
pp. 4874-4881 ◽  
Author(s):  
Ran Wan ◽  
Thomas Hong ◽  
Yasser Tariq ◽  
Andrew Chang

Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular traction was treated with vitrectomy surgery. In the past few years, there is a paradigm shift towards pharmacologic vitreolysis, which involves the intravitreal injection of enzymatic and non-enzymatic agents that facilitate posterior vitreous detachment. Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the progress and current status in this research.


2020 ◽  
Vol 4 (11) ◽  
pp. 1093-1102 ◽  
Author(s):  
Jessica A. Kraker ◽  
Judy E. Kim ◽  
Elizabeth C. Koller ◽  
Joshua C. George ◽  
Eileen S. Hwang

2005 ◽  
Vol 117 (3) ◽  
pp. 37-42 ◽  
Author(s):  
Curtis E. Margo ◽  
Lynn E. Harman

1995 ◽  
Vol 26 (1) ◽  
pp. 39-43
Author(s):  
Taiichi Hikichi ◽  
Hiroyuki Hirokawa ◽  
Masanori Kado ◽  
Jun Akiba ◽  
Akihiro Kakehashi ◽  
...  

2021 ◽  
pp. 247412642110467
Author(s):  
Ali H. Mannaa ◽  
Reda A. Issa ◽  
J. Shepard Bryan

Purpose: This work presents a case of significant improvement of optic pit disc maculopathy following an acute posterior vitreous detachment (PVD) and discusses the possible mechanisms of this phenomenon. Methods: A case report and review of the literature are presented. Results: A 56-year-old man presenting with progressive visual decline in his left eye was found to have an optic disc pit with optical coherence tomography (OCT) evidence of severe intraretinal edema and maculoschisis. His visual acuity and macular anatomy on OCT improved dramatically in the months following a PVD. Conclusions: This report presents an interesting case of spontaneous improvement of optic disc pit–related maculopathy following PVD. We discuss the cause of the retinal fluid accumulation in optic disc pit maculopathy and consider that the OCT findings in our case lend credence to the theory that this fluid originates from the vitreous humor.


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