Modulation of Estrogen Receptor Alpha Activity and Expression During Breast Cancer Progression

2013 ◽  
pp. 135-160 ◽  
Author(s):  
Gwenneg Kerdivel ◽  
Gilles Flouriot ◽  
Farzad Pakdel
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Progression ◽  
Estrogen Receptor Alpha ◽  
Alpha Activity ◽  
Breast Cancer Progression ◽  
Receptor Alpha

UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells

2017 ◽  
Vol 118 (8) ◽  
pp. 2347-2356 ◽  
Author(s):  
Nuria Sánchez-Morgan ◽  
Kathrin H. Kirsch ◽  
Philip C. Trackman ◽  
Gail E. Sonenshein
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Alpha Activity ◽  
Interacting Protein ◽  
Receptor Alpha

Estrogen Receptor Alpha and its Ubiquitination in Breast Cancer Cells

2019 ◽  
Vol 20 (6) ◽  
pp. 690-704 ◽  
Author(s):  
Angeles C. Tecalco-Cruz ◽  
Josué O. Ramírez-Jarquín ◽  
Eduardo Cruz-Ramos
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Protein Interactions ◽  
Posttranslational Modifications ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Development Of Resistance

More than 70% of all breast cancer cases are estrogen receptor alpha-positive (ERα). ERα is a member of the nuclear receptor family, and its activity is implicated in the gene transcription linked to the proliferation of breast cancer cells, as well as in extranuclear signaling pathways related to the development of resistance to endocrine therapy. Protein-protein interactions and posttranslational modifications of ERα underlie critical mechanisms that modulate its activity. In this review, the relationship between ERα and ubiquitin protein (Ub), was investigated in the context of breast cancer cells. Interestingly, Ub can bind covalently or non-covalently to ERα resulting in either a proteolytic or non-proteolytic fate for this receptor. Thereby, Ub-dependent molecular pathways that modulate ERα signaling may play a central role in breast cancer progression, and consequently, present critical targets for treatment of this disease.

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