Identification of coronary plaque mechanical properties from ex vivo testing

Puncture testing has been applied in several studies for the mechanical characterization of human fetal membrane (FM) tissue, and significant knowledge has been gained from these investigations. When comparing results of mechanical testing (puncture, inflation, and uniaxial tension), we have observed discrepancies in the rupture sequence of FM tissue and significant differences in the deformation behavior. This study was undertaken to clarify these discrepancies. Puncture experiments on FM samples were performed to reproduce previous findings, and numerical simulations were carried out to rationalize particular aspects of membrane failure. The results demonstrate that both rupture sequence and resistance to deformation depend on the samples' fixation. Soft fixation leads to slippage in the clamping, which reduces mechanical loading of the amnion layer and results in chorion rupturing first. Conversely, the stiffer, stronger, and less extensible amnion layer fails first if tight fixation is used. The results provide a novel insight into the interpretation of ex vivo testing as well as in vivo membrane rupture.

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Lipofection of early passages of cell cultures derived from murine adenocarcinomas: In vitro and ex vivo testing of the thymidine kinase/ganciclovir system

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700417 ◽

2002 ◽

Vol 9 (1) ◽

pp. 96-99 ◽

Cited By ~ 6

Author(s):

Armando L Karara ◽

Viviana F Bumaschny ◽

Gabriel L Fiszman ◽

Cecilia C Casais ◽

Gerardo C Glikin ◽

...

Keyword(s):

Thymidine Kinase ◽

Cell Cultures ◽

Ex Vivo ◽

Ex Vivo Testing

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Mechanical Properties of Healthy and ex vivo Onychomycosis Nails and the Influence of a Porphyrin-propylene Glycol Antifungal Formulation

British Journal of Applied Science & Technology ◽

10.9734/bjast/2016/23177 ◽

2016 ◽

Vol 14 (1) ◽

pp. 1-14 ◽

Cited By ~ 2

Author(s):

Amu Hosseinzoi ◽

Federica Galli ◽

Luca Incrocci ◽

Threes Smijs

Keyword(s):

Mechanical Properties ◽

Propylene Glycol ◽

Ex Vivo

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Ex vivo infiltration of fibroblasts into the tendon deteriorates the mechanical properties of tendon fascicles but not those of tendon bundles

Clinical Biomechanics ◽

10.1016/j.clinbiomech.2006.08.010 ◽

2007 ◽

Vol 22 (1) ◽

pp. 120-126 ◽

Cited By ~ 6

Author(s):

Yasunari Ikema ◽

Harukazu Tohyama ◽

Ei Yamamoto ◽

Fuminori Kanaya ◽

Kazunori Yasuda

Keyword(s):

Mechanical Properties ◽

Ex Vivo

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Design of a Multifunctional Forceps for Use in Endoscopic Surgery

Journal of Medical Devices ◽

10.1115/1.3442789 ◽

2010 ◽

Vol 4 (2) ◽

Author(s):

Andrew Rau ◽

Mary Frecker ◽

Abraham Mathew ◽

Eric Pauli

Keyword(s):

Minimally Invasive ◽

Endoscopic Surgery ◽

Minimally Invasive Surgical Procedures ◽

Ex Vivo ◽

Catastrophic Failure ◽

Minimally Invasive Surgical ◽

Design Characteristics ◽

Fail Safe ◽

Ex Vivo Testing ◽

Good Agreement

This paper presents a 3.0 mm diameter endoscopic forceps design for use in minimally invasive surgical procedures, which require significant grasping and spreading forces. Models of the proposed design predict considerable improvements in the opening range (140%) and force application (87%) for both grasping and spreading when compared with currently used endoscopic forceps. Several of the tool’s design characteristics promote fail-safe malfunctions, including locking before catastrophic failure and the decreased likelihood in detached parts. Initial benchtop testing showed good agreement between prototype performance and model prediction. Frictional losses experienced during testing were found to depend on load orientation. A surgical prototype is currently being manufactured for ex vivo testing.

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Ultrasound vibro-elastography for assessing mechanical properties of porcine reproductive tissues in an ex vivo model

Clinical Biomechanics ◽

10.1016/j.clinbiomech.2020.105093 ◽

2020 ◽

Vol 78 ◽

pp. 105093

Author(s):

Boran Zhou ◽

Juntao Shao ◽

Cassandra K. Kisby ◽

Xiaoming Zhang

Keyword(s):

Mechanical Properties ◽

Ex Vivo ◽

Ex Vivo Model ◽

Reproductive Tissues

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Harmonic motion imaging of human breast masses: an in vivo clinical feasibility

Scientific Reports ◽

10.1038/s41598-020-71960-5 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Niloufar Saharkhiz ◽

Richard Ha ◽

Bret Taback ◽

Xiaoyue Judy Li ◽

Rachel Weber ◽

...

Keyword(s):

Mechanical Properties ◽

Malignant Tumors ◽

Ex Vivo ◽

Benign Tumors ◽

Cancerous Tissue ◽

Breast Masses ◽

Harmonic Motion ◽

Harmonic Motion Imaging ◽

Motion Imaging

Abstract Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses.

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