Correlation of irritable bowel syndrome with psychiatric disorders

Background.Psychiatric comorbidity and visceral hypersensitivity are common in patients with irritable bowel syndrome (IBS), but little is known about visceral sensitivity in IBS patients without psychiatric disorders.Aim.We wanted to examine rectal visceral sensitivity in IBS patients without comorbid psychiatric disorders, IBS patients with phobic anxiety and healthy volunteers.Methods.A total of thirty-eight female, non-constipated IBS patients without psychiatric disorders and eleven female IBS patients with phobic anxiety were compared to nine healthy women using a barostat double random staircase method. The non-psychiatric patients were divided into those with diarrhoea predominant symptoms and those with alternating stool habits.Results.The IBS patients without psychiatric disorders had normal visceral pressure thresholds. However, in the diarrhoea predominant subgroup, the volume discomfort threshold was reduced while it was unchanged in those with alternating stool habits. The phobic IBS patients had similar thresholds to the healthy volunteers. The rectal tone was increased in the non-psychiatric IBS patients with diarrhoea predominant symptoms and in the IBS patients with phobic anxiety.Conclusions.Non-constipated IBS patients without psychiatric disorders had increased visceral sensitivity regarding volume thresholds but normal pressure thresholds. Our study suggests that the lowered volume threshold was due to increased rectal tone.

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Preliminary Study on the Correlations Between Oxytocin Levels and Irritable Bowel Syndrome in Patients with Depression

Revista de Chimie ◽

10.37358/rc.19.6.7305 ◽

2019 ◽

Vol 70 (6) ◽

pp. 2204-2206 ◽

Cited By ~ 1

Author(s):

Raluca Gavril ◽

Luminita Hritcu ◽

Manuela Padurariu ◽

Alin Ciobica ◽

Cristina Horhogea ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Major Depression ◽

Psychiatric Disorders ◽

Oxytocin Receptor ◽

Major Depression Disorder ◽

Digestive Disorder ◽

Key Factor ◽

Regulation Mechanisms ◽

Irritable Bowel ◽

Depression Disorder

Lately there are increased evidences that oxytocin may be an important mediator in several psychiatric disorders including depression and anxiety. Oxytocin system seems to be linked with several neurotransmitters important in psychiatric disorder, but also with the hypothalamic�pituitary�adrenal (HPA) axis and is also a key factor in stress regulation mechanisms. Considering the oxytocin receptor pattern of distribution both central and peripherally and the growing data concerning the disbalance of oxytocin in psychiatric disorders we may speculate that oxytocin system may be at the core of psychosomatic disturbances. Also, recent data brought to attention that oxytocin receptor is distributed throughout gastrointestinal tract. Our hypothesis of the present study was that oxytocin system is disbalanced in irritable bowel syndrome considering also the psychological component of this digestive disorder. We preliminary report here a significant decrease of serum oxytocin levels in patients with major depression disorder and irritable bowel syndrome, as compared with those with major depression disorder alone.

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Faculty Opinions recommendation of Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733478714.793548257 ◽

2018 ◽

Author(s):

Elspeth Guthrie

Keyword(s):

Irritable Bowel Syndrome ◽

Cohort Study ◽

Psychiatric Disorders ◽

Population Based ◽

Irritable Bowel

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Psychiatric Disorders in Patients with Irritable Bowel Syndrome at a Tertiary Care Centre in Bangladesh

Journal of Gastroenterology & Digestive Systems ◽

10.33140/jgda.04.01.03 ◽

2020 ◽

Vol 4 (1) ◽

Keyword(s):

Irritable Bowel Syndrome ◽

Psychiatric Disorders ◽

Psychiatric Illness ◽

Care Center ◽

General Health Questionnaire ◽

Tertiary Care ◽

Tertiary Care Center ◽

Asian Countries ◽

Significant Difference ◽

Irritable Bowel

Background/Aims: Irritable bowel syndrome (IBS) is one of the common functional gastrointestinal disorder. Psychosomatic illness is a common association with IBS. Although studies in both western and Asian countries showed significant coexisting psychiatric illness in IBS patients, such studies are scarce in south-east Asian countries like Bangladesh. So, the aim of this study was to find out the association of psychiatric co-morbidities in patients with IBS in a tertiary care center. Methods: This was a cross-sectional study conducted from July 2017 to January 2019. Patients were selected from the dedicated IBS clinic of a tertiary care center in Bangladesh. IBS population were enrolled according to the Rome-IV diagnostic criteria. Relevant history, physical examination and investigations were done to exclude organic diseases. A psychiatric assessment of all the study subjects was done by a clinical psychiatrist using the General Health Questionnaire (GHQ)-12. Results: Ninety-six IBS patients were enrolled in this study. The mean age was 33.51±9.87 years. Male outnumbered female (85.4% vs 14.6%). IBS diarrhea (83.3%) was predominant in this study. Approximately 60.41% of IBS patients had different psychiatric illnesses. Major depressive disorder (27.1%) and generalized anxiety disorder (15.6%) were the most common psychiatric illness in this study. There was no significant difference in psychiatric comorbidities among various IBS types. Conclusions: A significant number of IBS patients have co-morbid psychiatric disorders. So, IBS patients should meticulously be screened for such co-morbidities for effective and integrated management.

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