Ceftiofur Sodium | ScienceGate

Background: Antibiotic agents have been used in recent years to increase the growth of silkworm larvae and to improve production. In this context, the present investigation reported the effects of ceftiofur sodium, oxytetracycline and enroflaxcin on total haemocyte count (cells/mm3), survival percentage and economic characteristics in silkworm Bombyx mori L. at various concentration levels. The study regarding the effect of antibiotics was conducted on the silkworm breed APS-45. Three concentrations (0.05%, 0.10% and 0.15%) were prepared for each antibiotic. The worms were reared upto 3rd instar without any treatment. After third moult silkworms were supplemented with antibiotic fortified mulberry leaves. Results: The experimental results showed that the effect of different antibiotics on economic parameters like larval weight, larval duration, cocoon weight, shell ratio and raw silk percentage were significantly increased in the treated lines in comparison to the control. Antibiotics also increased survival percentage and the most effective result was obtained at 0.15% of ceftiofur sodium followed by oxytetracycline and enroflaxcin. In the present study highest THC value of 9157.33 mm/cm3 was recorded in treatment ceftiofur sodium treated batch at concentration C3 0.15%. An increment in the total haemocyte count was observed in other treatments as well and the cell count increased with an increase in concentration of antibiotic dosage and the effectiveness of the antibiotics followed the order ceftiofur sodium, oxytetracycline and enroflaxcin. Conclusion: This research outlines that there is a significant improvement in the total haemocyte count and economic traits in silkworm with the supplementation of antibiotic fortified mulberry leaves. The antibiotic treatment has significantly improved the raw silk percentage and has been found to be effective in reducing the mortality of silkworms. So, this antibiotic fortification can be further exploited for higher raw silk production.

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STABILITY STUDIES OF CEFTIOFUR SODIUM IN AQUEOUS SOLUTIONS AND IN THE SOLID PHASE

Acta Poloniae Pharmaceutica - Drug Research ◽

10.32383/appdr/90376 ◽

2018 ◽

Vol 75 (6) ◽

pp. 1279-1286

Author(s):

Agnieszka Dołhań ◽

Agnieszka Sobczak ◽

Izabela Muszalska ◽

Beata Medenecka ◽

Piotr Garbacki ◽

...

Keyword(s):

Aqueous Solutions ◽

Solid Phase ◽

Stability Studies ◽

Ceftiofur Sodium

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Development of an Ultraviolet Spectrophotometric Method for the Determination of Ceftiofur Sodium Powder

Journal of AOAC International ◽

10.1093/jaoac/92.6.1673 ◽

2009 ◽

Vol 92 (6) ◽

pp. 1673-1680 ◽

Cited By ~ 5

Author(s):

marinês J E Souza ◽

Natália Canedo ◽

Paulo S Souza Filho ◽

Ana M Bergold

Keyword(s):

Spectrophotometric Method ◽

Spectrophotometric Analysis ◽

Uv Spectrophotometry ◽

Accuracy And Precision ◽

Significant Difference ◽

Student’S T ◽

Ceftiofur Sodium ◽

Interday Precision ◽

Student’S T Test

Abstract A UV spectrophotometric method was developed for determination of ceftiofur sodium in the drug substance and sterile powder for injection. The method validation, which yielded good results, included evaluation of the range, linearity, intraand interday precision, accuracy, recovery, specificity, robustness, LOQ, and LOD. The UV spectrophotometric determinations were performed at 292 nm. Good linearity was obtained between 2.5 and 20.0 g/mL. A prospective validation showed that the method is linear (r = 0.9999) and precise, with RSD values of 0.3 for product A and 0.4 for product B. The intraand interday precision values were <2 for all samples analyzed. Comparison of UV spectrophotometry and LC by analysis of variance and Student's t-test showed no significant difference between methodologies. Moreover, the accuracy and precision obtained with the UV method correlated well with the values obtained with the LC method, and this correlation suggests that UV spectrophotometric analysis can be an inexpensive, reliable, and less time-consuming alternative to chromatographic analysis. The results demonstrated the validity of the proposed method as a simple and useful alternative for the determination of ceftiofur in routine QC analyses.

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