Additional Natural Killer Cell Leukemia-Lymphoma Cell Lines

2001 ◽  
pp. 697-698
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Lines ◽  
Killer Cell ◽  
Lymphoma Cell ◽  
Cell Leukemia

Transcription Factor Expression in Cell Lines Derived from Natural Killer-Cell and Natural Killer-Like T-Cell Leukemia-Lymphoma

Human Cell ◽  
2008 ◽  
Vol 17 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Yoshinobu MATSUO ◽  
Hans G. DREXLER ◽  
Akira HARASHIMA ◽  
Ayumi OKOCHI ◽  
Norio SHIMIZU ◽  
...  
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Lines ◽  
Killer Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Factor Expression ◽  
Transcription Factor Expression

scholarly journals A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation

Leukemia ◽  
2000 ◽  
Vol 14 (5) ◽  
pp. 922-930 ◽  
Author(s):  
M Yagita ◽  
CL Huang ◽  
H Umehara ◽  
Y Matsuo ◽  
R Tabata ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Line ◽  
Point Mutation ◽  
Killer Cell ◽  
Cell Leukemia ◽  
Natural Killer Cell Line

Overexpression of murine fizzy-related (fzr) increases natural killer cell–mediated cell death and suppresses tumor growth

Blood ◽  
2000 ◽  
Vol 96 (1) ◽  
pp. 259-263 ◽  
Author(s):  
Chun-Xiang Wang ◽  
Bernard C. Fisk ◽  
Madhuri Wadehra ◽  
Helen Su ◽  
Jonathan Braun
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Subtractive Hybridization ◽  
Cell Interaction ◽  
Tumor Formation ◽  
Lymphoma Cell ◽  
B Lymphoma ◽  
B Lymphoma Cells ◽  
Murine Homologue

Abstract Fizzy-related (fzr) is a recently identified 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. In this study, the murine homologue of fzr was isolated by suppression subtractive hybridization as a gene with decreased expression during malignant progression of a murine B-lymphoma cell line. Retroviral overexpression of fzr in B-lymphoma cells reduced tumor formation. Those tumors that did arise had diminished or extinguished retroviral Fzr. Surprisingly, fzr overexpression dramatically increased B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity, a host-resistant mechanism for tumor formation in this model system. These findings implicate fzr as a new category of genes suppressing B-cell tumorigenesis and suggest a novel role for fzr in the target cell interaction with NK cells.

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