Procalcitonin measurement using antibody-conjugated fluorescent microspheres distinguishes atypical bacterial meningitis from viral encephalitis in children

2021 ◽  
pp. 114219
Author(s):  
Xinquan Liu ◽  
Xingmiao Liu ◽  
Si Lin ◽  
Kang Du ◽  
Yu Ai ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Viral Encephalitis ◽  
Fluorescent Microspheres

scholarly journals Clinical Profile of Children with Acute Febrile Encephalopathy in a Tertiary Health Care Center of Nepal

2016 ◽  
Vol 35 (3) ◽  
pp. 224-230 ◽  
Author(s):  
Poonam Sharma ◽  
BK Sarmah ◽  
Pawana Kayastha ◽  
Asim Shrestha ◽  
Damodar Tiwari
Keyword(s):  
Bacterial Meningitis ◽  
Viral Encephalitis ◽  
Hospital Admissions ◽  
Care Center ◽  
Clinical History ◽  
Clinical Findings ◽  
Respiratory Pattern ◽  
Health Care Center ◽  
Altered Sensorium ◽  
Geographical Regions

Background: Acute febrile encephalopathy is a common and severe neurological syndrome that is associated with significant morbidity and mortality in children. The etiologies differ according to geographical regions and appropriate and efficient protocols for investigations and management requires proper understanding of various potential etiologies.Methods: In this prospective observational study, 54 children of one month to 14 years presenting to the hospital with acute onset of fever with altered sensorium were clinically evaluated and investigated. Clinical examinations included temperature, pulse rate, heart rate, blood pressure, coma severity by GCS, respiratory pattern and detail systemic and CNS examination. Etiology of acute febrile encephalopathy was based on clinical history, examination and relevant laboratory investigations.Results:  The incidence of acute febrile encephalopathy was 5.5% of the total hospital admissions. There were 35(64.8%) boys and 19(35.2%) girls. The maximum number of children 24(44.4%) were between one to five years of age. The most common presenting complains besides fever and altered sensorium were seizures and vomiting which was present in 59.3% and 46.3% of children respectively. Signs of meningeal irritation, hypertonia, brisk deep tendon reflexes and extensor plantar response was present in 50%, 24%, 29.6%, and 44.4% respectively. The diagnosis based on clinical findings and laboratory investigations were viral encephalitis 34(63%), bacterial meningitis 12(22.2%), cerebral malaria 4(7.4), enteric encephalopathy 3(5.6%) and hepatic encephalopathy 1(1.9%).Conclusion: Viral encephalitis and bacterial meningitis are the most common cause of acute febrile encephalopathy. Preventive strategies can be done to decrease the incidence.J Nepal Paediatr Soc 2015;35(3):224-230

scholarly journals Spectrum of central nervous system infections in neurosciences hospital in two years : a retrospective study

2020 ◽  
Vol 16 (1) ◽  
pp. 67-73
Author(s):  
Aiyar Shakir Jawad
Keyword(s):  
Spinal Cord ◽  
Bacterial Meningitis ◽  
Tuberculous Meningitis ◽  
Viral Encephalitis ◽  
Viral Meningitis ◽  
Preschool Age ◽  
Clinical Aspects ◽  
High Morbidity ◽  
Focal Neurological Deficit ◽  
Cns Infections

Background :Infectious disorders in general have high morbidity and mortality.. CNS infections include many disorders like bacterial meningitis, tuberculous and other subacute and chronic meningitis, viral meningitis, cerebral abscess, spinal cord infections, and others.Objective: To assess our locality about prevalence of CNS infections , to have more awareness regarding CNS infections, and to try to find the proper way to reduce their prevalence and to treat them in appropriate way.Method :We revised the records of all the cases of CNS infections excluding cases of spinal cord infections who were admitted in the wards of neuroscience hospital over the previous two years ( from July/2010 to June 2012 ),those were 132 cases.Seasonal incidenceand other clinical aspects and other parameters like age , sex, , fever are extracted and recordedResults: The most common CNS infections in sequence from the most to the least were bacterial meningitis, viral encephalitis, tuberculous meningitis, viral meningitis, and cerebral abscess.The most common age group which is affected by CNS infections was below 10 years.Males are affected more than females taking in consideration all types of infection.P values were statistically significant for age, fever, signs of meningeal irritation, focal neurological deficit, and seizures.Conclusion : The total rate of admission of CNS infections in our series was lower than other study.The most frequent type of CNS infections was bacterial meningitis which is the same as most of the studies.Males are affected more than females in our study in all types of CNS infections, this was approximate to other studies except for tuberculous meningitis.Bacterial meningitis and viral encephalitis were more common in preschool children in our study.Fever rate in bacterial and tuberculous meningitis was different from other studies.Seizure rate in bacterial meningitis and viral encephalitis was approximate to other results.Rate of focal deficit in viral encephalitis and tuberculous meningitis was different from other studies.Rate of CSF protein elevation in all CNS infections was approximate to other studies.Rate of hypoglycorrhachia was different from other studies only in tuberculous meningitis.CSF pleocytosis was approximate to other studies in all types of CNS infections.The two most common types of CNS infections , bacterial meningitis and viral encephalitis, are more common in preschool age groups.

Glycerol Aids Outcomes in Bacterial Meningitis

2005 ◽  
Vol 39 (2) ◽  
pp. 11
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Bacterial Meningitis

Outbreak Of Nipah Encephalitis In Greater Faridpur District

1970 ◽  
Vol 5 (2) ◽  
pp. 63-65
Author(s):  
MY Ali ◽  
SA Fattah ◽  
MM Islam ◽  
MA Hossain ◽  
SY Ali
Keyword(s):  
Health Personnel ◽  
Viral Encephalitis ◽  
Review Article ◽  
Personal Protection ◽  
Emerging Infections ◽  
College Hospital ◽  
Personal Protection Equipment ◽  
Medical College ◽  
History Of ◽  
Deadly Disease

Nipah viral encephalitis is one of the fatal re-emerging infections especially in southeast Asia. After its outbreak in Malaysia and Singapore; repeated outbreaks occurred at western part of Bangladesh especially in Faridpur region. Besides, sporadic attacks appear to occur in the country throughout the year. Here two Nipah outbreaks in greater Faridpur district in 2003 and 2004 are described along with brief review on transmission of the virus. Where the history of illness among patients are very much in favour of man to man transmission. Moreover the death of an intern doctor from Nipah encephalitis who was involved in managing such patients in Faridpur Medical College Hospital strongly suggests man to man transmission of this virus. So, aim of this review article to make the health personnel and general people be aware about man to man transmission of virus, so that they can adapt personal protection equipment (PPE) for their protection against this deadly disease. DOI: 10.3329/fmcj.v5i2.6825Faridpur Med. Coll. J. 2010;5(2):63-65

Chapter 10: Diagnosis

2019 ◽  
Author(s):  
Gerhard Dobler
Keyword(s):  
Cerebrospinal Fluid ◽  
Viral Encephalitis ◽  
Clinical Symptoms ◽  
Serological Tests ◽  
Specific Antibodies ◽  
Cross Reactions ◽  
Neuro Imaging ◽  
Tbev Infection

• TBE appears with non-characteristic clinical symptoms, which cannot be distinguished from oth-er forms of viral encephalitis or other diseases. • Cerebrospinal fluid and neuro-imaging may give some evidence of TBE, but ultimately cannot confirm the diagnosis. • Thus, proving the diagnosis “TBE” necessarily requires confirmation of TBEV-infection by detec-tion of the virus or by demonstration of specific antibodies from serum and/or cerebrospinal fluid. • During the phase of clinic symptoms from the CNS, the TBEV can only rarely be detected in the cerebrospinal fluid of patients. • Most routinely used serological tests for diagnosing TBE (ELISA, HI, IFA) show cross reactions resulting from either Infection with other flaviviruses or with other flavivirus vaccines.

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