Nanostructured conducting molecularly imprinted polymer for selective extraction of salicylate from urine and serum samples by electrochemically controlled solid-phase micro-extraction

2011 ◽  
Vol 707 (1-2) ◽  
pp. 62-68 ◽  
Author(s):  
Akram Ameli ◽  
Naader Alizadeh
Author(s):  
Meilia Suherman ◽  
Ike Susanti ◽  
Driyanti Rahayu ◽  
Rimadani Pratiwi ◽  
Aliya Nur Hasanah

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.


RSC Advances ◽  
2017 ◽  
Vol 7 (54) ◽  
pp. 34077-34085 ◽  
Author(s):  
Xinwei Chen ◽  
Nengsheng Ye

Graphene oxide–functionalized molecularly imprinted polymer particles have been prepared for specific selective extraction and determination of cefadroxil in environmental water samples.


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