scholarly journals Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum

2018 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Meilia Suherman ◽  
Ike Susanti ◽  
Driyanti Rahayu ◽  
Rimadani Pratiwi ◽  
Aliya Nur Hasanah
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Therapeutic Index ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Precipitation Polymerization ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
As Doping ◽  
Recovery Percentage

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.

scholarly journals Application of molecularly imprinted polymer designed for the selective extraction of ketoprofen from wastewater

Water SA ◽  
2018 ◽  
Vol 44 (3 July) ◽  
Author(s):  
Lawrence Mzukisi Madikizela ◽  
Silindile Senamile Zunngu ◽  
Nomchenge Yamkelani Mlunguza ◽  
Nikita Tawanda Tavengwa ◽  
Phumlane Selby Mdluli ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Selectivity Coefficient ◽  
Dynamics Simulation ◽  
Maximum Adsorption Capacity ◽  
Order Kinetic ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A molecularly imprinted polymer (MIP) that is selective to ketoprofen was synthesized and applied in the adsorption of the target compound from water. The MIP was synthesized using a bulk polymerization method at high temperatures (60–80°C), where ketoprofen, 2-vinylpyridine, ethylene glycol dimethacrylate, toluene and 1,1´-azobis(cyclohexanecarbonitrile) were used as template, functional monomer, cross-linker, porogen and initiator, respectively. Non-imprinted polymer (NIP) was synthesized similarly to the MIP but in the absence of ketoprofen. From molecular dynamics simulation, the nature of interactions that occurred between the template and the functional monomer were found to be based on hydrogen bonding. This was confirmed experimentally, where a high extraction efficiency of ≥ 90% was obtained at acidic conditions (pH 5) due to the protonation of ketoprofen. A contact time of 45 min was sufficient for the maximum adsorption of ketoprofen from 10 mL spiked water using 8 mg of the adsorbent. MIP showed greater selectivity than NIP by achieving a relative selectivity coefficient of 7.7 towards ketoprofen in the presence of structurally related pharmaceuticals. Furthermore, the order of sorption onto the MIPs from water was ketoprofen > fenoprofen > gemfibrozil. From a modelling perspective, the Langmuir adsorption isotherm and pseudo-second-order kinetic model gave the best fit, with maximum adsorption capacity of 8.24 mg·g−1 and sorption rate constant of 0.25 mg·g−1·min−1 for MIP. This was translated to chemisorption of ketoprofen onto the homogeneous MIP binding sites. This work demonstrated the great potential of MIP in selective recognition of ketoprofen from wastewater relative to closely related compounds.

scholarly journals A graphene oxide surface–molecularly imprinted polymer as a dispersive solid-phase extraction adsorbent for the determination of cefadroxil in water samples

RSC Advances ◽  
2017 ◽  
Vol 7 (54) ◽  
pp. 34077-34085 ◽  
Author(s):  
Xinwei Chen ◽  
Nengsheng Ye
Keyword(s):  
Graphene Oxide ◽  
Molecularly Imprinted Polymer ◽  
Water Samples ◽  
Solid Phase ◽  
Environmental Water ◽  
Selective Extraction ◽  
Oxide Surface ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Graphene oxide–functionalized molecularly imprinted polymer particles have been prepared for specific selective extraction and determination of cefadroxil in environmental water samples.

scholarly journals Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

2013 ◽  
Vol 63 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Rym Lahsini ◽  
Mohamed R. Louhaichi ◽  
Nafaa Adhoum ◽  
Lotfi Monser
Keyword(s):  
Molecularly Imprinted Polymer ◽  
High Performance ◽  
Solid Phase ◽  
Industrial Process ◽  
Direct Determination ◽  
Dimethyl Formamide ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Recovery Percentage

The performance of a molecularly imprinted polymer (MIP) as selective packing material for solid-phase extraction (SPE) of residual glibenclamide in an industrial process was investigated. MIP was prepared using 4-vinylpyridine as monomer, ethylenedimethacrylate as cross linker, 2,2’-azobis-2-methylpropionitrile as initiator and dimethyl formamide as porogen. Use of acetonitrile as a rebinding solvent allows good recognition of the glibenclamide template. It was found that this polymer can be used for determination of trace levels of glibenclamide with a recovery percentage that could reach 87.1 %. Furthermore, the synthesized MIP showed higher selectivity towards glibenclamide than other compounds such as glimepiride and metformine. The synthesized MIP enabled direct determination of the target contaminant after an enrichment step that allowed quantification of glibenclamide at a concentration as low as 0.016 mg L-1. Combination of high performance liquid chromatography with MIP-SPE could be successfully used for quality control of pharmaceuticals during the cleaning process in the production of dry drug forms.

scholarly journals Synthesis and Evaluation of Molecularly Imprinted Polymer for the Determination of the Phthalate Esters in the Bottled Beverages by HPLC

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Ya-Feng Jin ◽  
Yi-Jun Zhang ◽  
Yu-Ping Zhang ◽  
Jun Chen ◽  
Xiao-Mao Zhou ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Phthalate Esters ◽  
Bulk Polymerization ◽  
Sample Volume ◽  
Scatchard Analysis ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Relative Standard ◽  
Ethylene Dimethacrylate

A molecularly imprinted polymer (MIP) was prepared in acetonitrile by bulk polymerization, using di-n-octylphthalate (DOP) as a template molecular,α-methacrylic acid (MAA) as a functional monomer, and ethylene dimethacrylate (EDMA) as a crosslinker. Characterization and evaluation of the prepared MIP were carried out by scanning electron microscope (SEM), infrared absorption spectroscopy (IR), and the Scatchard analysis, respectively. Through the optimization of washing solvent, eluting solvent amount, flow rate of loading solution, and loading sample volume, an analysis method was established for DOP related compounds with high selectivity and sensitivity by using the selective molecularly imprinted solid-phase extraction (MI-SPE) technique. Moreover, under the optimal conditions, the extraction effects were comparatively investigated by using MIP cartridge, NIP cartridge, and the commercial PLS cartridge used especially for phthalic acid esters (PAEs), respectively. The results showed that the recoveries of spiked PAEs are in the range of 90.4%–97.8% with the relative standard deviation (RSD) of 1.6%–3.8% on the resulted MIP cartridge, whilst lower recoveries were obtained ranging from 80.2% to 88.9% with an RSD of 1.4%–5.2% on the commercial PLS cartridge.

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