Highly-sensitive label-free electrochemical carcinoembryonic antigen immunosensor based on a novel Au nanoparticles–graphene–chitosan nanocomposite cryogel electrode

2015 ◽  
Vol 853 ◽  
pp. 521-532 ◽  
Author(s):  
Saluma Samanman ◽  
Apon Numnuam ◽  
Warakorn Limbut ◽  
Proespichaya Kanatharana ◽  
Panote Thavarungkul
Keyword(s):  
Carcinoembryonic Antigen ◽  
Au Nanoparticles ◽  
Label Free ◽  
Highly Sensitive

A highly sensitive label-free resonance light scattering assay of carcinoembryonic antigen based on immune complexes

2012 ◽  
Vol 747 ◽  
pp. 99-105 ◽  
Author(s):  
Zhanguang Chen ◽  
Yulong Lei ◽  
Zhisen Liang ◽  
Fengji Li ◽  
Lidong Liu ◽  
...  
Keyword(s):  
Light Scattering ◽  
Carcinoembryonic Antigen ◽  
Immune Complexes ◽  
Resonance Light Scattering ◽  
Label Free ◽  
Highly Sensitive

A highly sensitive label-free electrochemical immunosensor based on an aligned GaN nanowires array/polydopamine heterointerface modified with Au nanoparticles

2019 ◽  
Vol 7 (9) ◽  
pp. 1442-1449 ◽  
Author(s):  
Qingyun Liu ◽  
Taotao Yang ◽  
Yongqin Ye ◽  
Ping Chen ◽  
Xiaoning Ren ◽  
...  
Keyword(s):  
Au Nanoparticles ◽  
Nanowire Array ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Array Configuration ◽  
Gan Nanowires ◽  
Nanowire Surface ◽  
Highly Sensitive ◽  
Gan Nanowire ◽  
Nanowires Array

Taking advantage of a nanowire array configuration and a semiconductor/polymer heterointerface, a highly sensitive label-free electrochemical immunosensor was developed through integration of polydopamine on an aligned GaN nanowire surface.

A label-free electrochemistry biosensor based flower-like 3-dimensional ZnO superstructures for detection of DNA arrays

2014 ◽  
Vol 38 (12) ◽  
pp. 5918-5924 ◽  
Author(s):  
Linxia Fang ◽  
Kejing Huang ◽  
Baoling Zhang ◽  
Yujie Liu ◽  
Qiuyu Zhang
Keyword(s):  
Au Nanoparticles ◽  
Dna Sensor ◽  
Label Free ◽  
Dna Arrays ◽  
3 Dimensional ◽  
Electrochemical Dna Sensor ◽  
Highly Sensitive

A highly sensitive electrochemical DNA sensor was constructed by homogenously distributing Au nanoparticles (AuNPs) on a flower-like 3D ZnO superstructure–chitosan (CS) matrix.

A Label-Free Electrochemical Immunosensor for Carcinoembryonic Antigen Based on Graphene and Thionine

2013 ◽  
Vol 643 ◽  
pp. 29-32 ◽  
Author(s):  
Jing Man Han ◽  
Zhan Fang Ma
Keyword(s):  
Carcinoembryonic Antigen ◽  
Glassy Carbon ◽  
Electrode Surface ◽  
Au Nanoparticles ◽  
Electrochemical Immunosensor ◽  
Carbon Electrode ◽  
Label Free ◽  
Optimal Conditions ◽  
Redox Species ◽  
Electrode Surfaces

A label-free immunosensor was developed to detect the presence of an antigen. This immunosensor was based on the modulation of the electrochemistry of the surface bound redox species thionine (Thi). The model antigen was carcinoembryonic antigen (CEA) and the model epitope was the antibody of CEA (anti-CEA). Glassy carbon electrode surfaces were first drop-coated with a mixture of graphene, Thi and Nafion and air-dried. The electrode surface was then electrodeposited in HAuCl4solution to form Au nanoparticles (AuNPs). The resulted AuNPs were used to immobilize anti-CEA. Binding of CEA to the surface bound epitope resulted in the attenuation of the Thi electrochemistry. Under optimal conditions, the response of the label-free immunosensor had a liner range from 10 fg/mL to 100 ng/mL with a detection of 3.5 fg/mL (S/N=3).

A label-free electrochemical immunosensor for carcinoembryonic antigen detection on a graphene platform doped with poly(3,4-ethylenedioxythiophene)/Au nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (106) ◽  
pp. 86910-86918 ◽  
Author(s):  
Yan-Sha Gao ◽  
Jing-Kun Xu ◽  
Li-Min Lu ◽  
Xiao-Fei Zhu ◽  
Wen-Min Wang ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Au Nanoparticles ◽  
Electrochemical Immunosensor ◽  
Antigen Detection ◽  
Label Free ◽  
Step Method ◽  
Sensing Platform

In this work, a two-step method was developed for the fabrication of a graphene sensing platform doped with poly(3,4-ethylenedioxythiophene)/Au nanoparticles (AuNPs/PEDOT/GR).

scholarly journals Optical Monitoring of the Production Quality of Si-Nanoribbon Chips Intended for the Detection of ASD-Associated Oligonucleotides

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 147
Author(s):  
Kristina A. Malsagova ◽  
Tatyana O. Pleshakova ◽  
Vladimir P. Popov ◽  
Igor N. Kupriyanov ◽  
Rafael A. Galiullin ◽  
...  
Keyword(s):  
Production Quality ◽  
Autism Spectrum ◽  
Covalent Immobilization ◽  
Biological Macromolecules ◽  
Label Free ◽  
Raman Scattering Spectroscopy ◽  
Dna Oligonucleotides ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for highly sensitive detection of biological macromolecules. The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. The specificity of the analysis was attained by the sensitization of the Si-NR chip sur-face by covalent immobilization of oDNA probes, whose nucleotide sequence was complementary to the known sequence of miR-106a-5p. The use of the Si-NR chip was demonstrated to al-low for the rapid label-free real-time detection of oDNA at ultra-low (~10−17 M) concentrations.

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