Two-phase micro-electromembrane extraction across free liquid membrane for determination of acidic drugs in complex samples

2019 ◽  
Vol 1048 ◽  
pp. 58-65 ◽  
Author(s):  
Andrea Šlampová ◽  
Pavel Kubáň
2010 ◽  
Vol 64 (3) ◽  
pp. 221-225
Author(s):  
J. Djordjevic ◽  
T. Trtic-Petrovic ◽  
K. Kumric ◽  
M. Purenovic

This paper analyzes the conditions for membrane extraction of pesticides using ACD / LABS 12 program. The program contains a large database of more than 2000 compounds and their ionized species, for determining the pKa, further analysis includes 600 new compounds confirmed by Hammett?s equation, which gives more precise values for logD and solubility. The 16 pesticides of different classes (organophosphates, carbamates, carbamidas, neonicotinoids etc.) and polarities commonly used in Serbia were examined. The program is used to calculate logD, pKa and solubility at different pH values for the mixture of pesticides. Based on the calculated values, the conditions for the extraction of pesticides in water using two-phase liquid-liquid membrane extraction were optimized.


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