Supercritical fluid-assisted preparation of imprinted contact lenses for drug delivery

2011 ◽  
Vol 7 (3) ◽  
pp. 1019-1030 ◽  
Author(s):  
Fernando Yañez ◽  
Lahja Martikainen ◽  
Mara E.M. Braga ◽  
Carmen Alvarez-Lorenzo ◽  
Angel Concheiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Fluid ◽  
Contact Lenses

scholarly journals A review on therapeutic contact lenses for ocular drug delivery

Drug Delivery ◽  
2016 ◽  
Vol 23 (8) ◽  
pp. 3017-3026 ◽  
Author(s):  
Furqan A. Maulvi ◽  
Tejal G. Soni ◽  
Dinesh O. Shah
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Ocular Drug Delivery

scholarly journals Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaohong Hu ◽  
Lingyun Hao ◽  
Huaiqing Wang ◽  
Xiaoli Yang ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Contact Lenses ◽  
Drug Carriers ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

scholarly journals Patients’ and prescribers’ perception of contact lenses as a potential ocular drug delivery system

2019 ◽  
Vol 42 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Heba Ghazal ◽  
Judy Ahmadouk ◽  
Sumayya Dhanji ◽  
Amani El-bushra ◽  
Reem Kayyali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Contact Lenses ◽  
Ocular Drug Delivery

Contact lenses with dual drug delivery for the treatment of bacterial conjunctivitis

2018 ◽  
Vol 548 (1) ◽  
pp. 139-150 ◽  
Author(s):  
Furqan A. Maulvi ◽  
Sulabh S. Singhania ◽  
Ankita R. Desai ◽  
Manish R. Shukla ◽  
Aniruddha S. Tannk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Bacterial Conjunctivitis ◽  
Dual Drug

Inner layer-embedded contact lenses for ion-triggered controlled drug delivery

2018 ◽  
Vol 93 ◽  
pp. 36-48 ◽  
Author(s):  
Qiang Zhu ◽  
Yidan Wei ◽  
Conghao Li ◽  
Shirui Mao
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Controlled Drug Delivery

The Effect of Photoinitiator Concentration on the Physicochemical Properties of Hydrogel Contact Lenses

2014 ◽  
Vol 679 ◽  
pp. 118-127 ◽  
Author(s):  
Deirdre M. McElroy ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
Sinead M. Devery
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Contact Lens ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.

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