Integrated polycaprolactone microsphere-based scaffolds with biomimetic hierarchy and tunable vascularization for osteochondral repair

Author(s):  
Xiang Gu ◽  
Yao Zha ◽  
Yawu Li ◽  
Jia Chen ◽  
Shuaibing Liu ◽  
...  
Keyword(s):  
Cartilage ◽  
2021 ◽  
pp. 194760352110219
Author(s):  
Jonny K. Andersson ◽  
Elisabet Hagert ◽  
Mats Brittberg

Objective: Focal cartilage injuries, and posttraumatic osteoarthritis (OA) in the wrist are likely common and a cause of wrist pain. To estimate the incidence of cartilage lesions and to understand the pathomechanisms leading to wrist cartilage injuries and OA, a literature review on the subject was performed combined with a presentation of one of the authors’ own experience. Design: This study includes a literature review of the topic. As a comparison to the review findings, the observations of one of the authors’ consecutive 48 wrist arthroscopies, were assessed. PubMed, Scholar, and Cochrane databases were searched using the keywords “cartilage injury AND wrist AND treatment” and “wrist AND cartilage AND chondral AND osteochondral AND degenerative OA.” :Result A total of 11 articles, including 9 concerning chondral and osteochondral repair and treatment and 2 regarding posttraumatic OA, were retrieved. The cartilage repair treatments used in these articles were drilling, osteochondral autograft, juvenile articular cartilage allograft, and chondrocyte implantation. One article displayed concomitant cartilage injuries in displaced distal radius fractures in 32% of the patients. The review of our findings from a 1-year cohort of wrist arthroscopies showed 17% cartilage injuries. Conclusion: There is a lack of knowledge in current literature on cartilage injuries and treatment, as well as posttraumatic OA in the wrist. Cartilage injuries appear to be common, being found in 17% to 32% of all wrist arthroscopies after trauma, but no guidelines regarding conservative or surgical treatment can be recommended at the moment. Larger prospective comparative studies are needed.


Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S113
Author(s):  
W. Toh ◽  
S. Zhang ◽  
K. Wong ◽  
X. Ren ◽  
R. Lai ◽  
...  

Biomaterials ◽  
2015 ◽  
Vol 39 ◽  
pp. 114-123 ◽  
Author(s):  
Pengfei Chen ◽  
Jiadong Tao ◽  
Shouan Zhu ◽  
Youzhi Cai ◽  
Qijiang Mao ◽  
...  

2014 ◽  
Vol 24 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Elizaveta Kon ◽  
Giuseppe Filardo ◽  
Francesco Perdisa ◽  
Giulia Venieri ◽  
Maurilio Marcacci

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 9089-9096 ◽  
Author(s):  
Newsha Koushki ◽  
Ali Asghar Katbab ◽  
Hossein Tavassoli ◽  
Azadeh Jahanbakhsh ◽  
Mohammad Majidi ◽  
...  

Fabrication of an injectable biphasic hydrogel based on partially hydrolyzed polyacrylamide (HPAM), nanocrystalline hydroxyapatite (nHAp), and chromium acetate (Cr(iii)) as a novel scaffold for osteochondral repair has been attempted.


2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Meng Wang ◽  
Yixuan Luo ◽  
Yin Yu ◽  
Fei Chen

The osteochondral tissue is an interface between articular cartilage and bone. The diverse composition, mechanical properties, and cell phenotype in these two tissues pose a big challenge for the reconstruction of the defected interface. Due to the availability and inherent regenerative therapeutic properties, stem cells provide tremendous promise to repair osteochondral defect. This review is aimed at highlighting recent progress in utilizing bioengineering approaches to improve stem cell therapies for osteochondral diseases, which include microgel encapsulation, adhesive bioinks, and bioprinting to control the administration and distribution. We will also explore utilizing synthetic biology tools to control the differentiation fate and deliver therapeutic biomolecules to modulate the immune response. Finally, future directions and opportunities in the development of more potent and predictable stem cell therapies for osteochondral repair are discussed.


2012 ◽  
Vol 23 ◽  
pp. 222-246 ◽  
Author(s):  
S Miot ◽  
◽  
W Brehm ◽  
S Dickinson ◽  
T Sims ◽  
...  

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