Predictive factors associated with subclinical altered left ventricular function in children with sickle cell anemia

BackgroundEnumerating the relationship between cardiac structures, function and chamber sizes in children with sickle cell anemia would help in delineating some cardiovascular abnormalities which will aid the Pediatric cardiologist and the cardiac surgeons in a number of decision-making situations.ObjectivesThe objectives of this study are to assess the dimension of cardiac structures and left ventricular function in children with sickle cell anemia in steady state and controls using echocardiography.MethodsA cross-sectional prospective study that assessed cardiac structures and left ventricular function among fifty-one children with sickle cell anemia (HBSS) and compared with fifty children with HB AA type serving as controls.ResultsA significant high proportion of children with sickle cell anemia had abnormal Valvar dimension and left ventricular function above two standard deviations (2-SD) from the mean of the standard population compared to the control group, showing a statistically significant difference (χ2 = 10.42, p= 0.001). All the mean annular valves diameter, left ventricular internal dimension in systole and diastole, inter-sinus distance diameter and sinu-tubular junction diameter are higher in children with sickle cell anemia than controls and this is statistically significant. (p<0.005). ConclusionThis result shows that children with sickle cell anemia have increased valvar size diameter compared with those with normal hemoglobin type. A significantly higher proportion of respondents in type SS group had abnormal left ventricular systolic and diastolic dysfunction when compared with those in type AA group

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ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT VENTRICULAR FUNCTION IN CHILDREN WITH SICKLE CELL ANEMIA

Pediatric Research ◽

10.1203/00006450-197704000-00172 ◽

1977 ◽

Vol 11 (4) ◽

pp. 398-398

Author(s):

Allan Rees ◽

Miltiadis Stefadouros ◽

William Strong ◽

Max Miller ◽

Judy Rigby ◽

...

Keyword(s):

Left Ventricular Function ◽

Ventricular Function ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Left Ventricular ◽

Echocardiographic Assessment

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Left ventricular function, morphology, and myocardial tissue characterization in Sickle Cell Disease: a multi-modality imaging study

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/1532-429x-13-s1-p334 ◽

2011 ◽

Vol 13 (S1) ◽

Author(s):

Ahmad Homaa ◽

Ankit A Desai ◽

Roberto M Lang ◽

Thejasvi Thiruvoipati ◽

Kristen Turner ◽

...

Keyword(s):

Sickle Cell Disease ◽

Left Ventricular Function ◽

Ventricular Function ◽

Sickle Cell ◽

Tissue Characterization ◽

Imaging Study ◽

Left Ventricular ◽

Myocardial Tissue ◽

Cell Disease ◽

Myocardial Tissue Characterization

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Factors associated with cognitive recovery after cardiopulmonary resuscitation

American Journal of Critical Care ◽

10.4037/ajcc1996.5.2.127 ◽

1996 ◽

Vol 5 (2) ◽

pp. 127-139 ◽

Cited By ~ 54

Author(s):

MJ Sauve ◽

N Doolittle ◽

JA Walker ◽

SM Paul ◽

MM Scheinman

Keyword(s):

Sudden Cardiac Death ◽

Cardiopulmonary Resuscitation ◽

Left Ventricular Function ◽

Ventricular Function ◽

Cardiac Death ◽

Left Ventricular ◽

Cognitive Outcomes ◽

Factors Associated ◽

Over Time ◽

Cognitive Areas

BACKGROUND: A range of neuro-cognitive sequelae, from mild intellectual impairments to brain death, have been reported in survivors of aborted sudden cardiac death. PURPOSE: To determine to what extent, if any, factors associated with cardiopulmonary resuscitation, left ventricular function, and mood state are related to outcomes in five cognitive areas, namely orientation, attention, memory, reasoning, and motor performance. METHODS: Repeated measures were used to assess cognitive outcomes in 45 sudden cardiac arrest survivors over the 6 months following cardiopulmonary resuscitation. A battery of neuro-psychological tests was used to assess cognitive outcomes and psychological status over time. The relationship of the cardiopulmonary resuscitation, left ventricular function, and psychological variables to cognitive outcomes were assessed at each data point. The independent variables included time to cardiopulmonary resuscitation, time to defibrillation, duration of cardiopulmonary resuscitation, time to awakening, ejection fraction, New York Heart Association Class I to IV, tension, anger, and depression. RESULTS: During hospitalization 38 of the 45 survivors (84%) had mild to severe deficits in one or more cognitive areas; 19 of 38 survivors (50%) continued to be impaired in one or more cognitive areas at 6 months. Of these, all had mild to severe deficits in at least one aspect of memory, with delayed recall the most frequent impairment. Time to awakening accounted for a unique portion of the variance in orientation and memory outcomes over time. The left ventricular function variables accounted for a significant portion of the variance in motor speed. CONCLUSIONS: Our results suggest that half of the long-term survivors of aborted sudden cardiac death are cognitively intact 6 months after resuscitation but that 25% have moderate to severe impairment in memory, which could hamper and/or preclude the resumption of prearrest roles.

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