scholarly journals Plain language summary for “Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: systematic review and meta-analysis—a report of the American Dental Association”

2019 ◽  
Vol 150 (12) ◽  
pp. 1048-1050
Author(s):  
Malavika P. Tampi ◽  
Lauren Pilcher ◽  
Olivia Urquhart ◽  
Sarah C. Pahlke ◽  
Kelly K. O’Brien ◽  
...  
Author(s):  
C.S. Tibúrcio‐Machado ◽  
C. Michelon ◽  
F.B. Zanatta ◽  
M.S. Gomes ◽  
J.A. Marin ◽  
...  

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S31-S32
Author(s):  
Daniel Carlsen ◽  
Katie J Suda ◽  
Ursula C Patel ◽  
Gretchen Gibson ◽  
Marianne M Jurasic ◽  
...  

Abstract Background US dentists prescribe 10% of outpatient antibiotics. However, assessing the appropriateness of dental antibiotic prescribing has been challenging due to a lack of guidelines for common infections. In 2019, the American Dental Association proposed clinical practice guidelines (CPG) on the management of common acute oral infections for the first time. Our objective was to describe national baseline antibiotic prescribing for the treatment of irreversible pulpitis, apical periodontitis, and acute apical abscess prior to the release of the proposed CPG. Methods We performed a cross-sectional analysis of national VA data from January 1, 2017 to December 31, 2017. We identified cases of irreversible pulpitis, apical periodontitis, and acute apical abscess using ICD-10-CM codes. Patient demographics, facility location, medical conditions, dental procedure codes (“CDTs”), and diagnostic (ICD-10-CM) codes were extracted from the VA Corporate Data Warehouse. Antibiotics prescribed by a dentist within 7 days of a visit were included. Multivariable logistic regression identified variables associated with antibiotic prescribing for each infection. Results Of the 470,039 VA dental visits with oral infections coded, 25% of irreversible pulpitis, 41% of apical periodontitis, and 61% of acute apical abscess visits received antibiotics. Amoxicillin was prescribed most frequently. Although the median days’ supply was 7 days, prolonged use of antibiotics was frequent (9.2% of irreversible pulpitis, 17.8% of apical periodontitis, 28.7% of acute apical abscess received antibiotics for ≥8 days). Of the irreversible pulpitis visits with antibiotics prescribed, 20.0% received ≥2 antibiotics. Patients with high-risk cardiac conditions, prosthetic joints, and certain dental procedures were associated with receipt of antibiotics (table). Conclusion Prior to the release of the ADA guidelines, 75.8% and 59.4% of irreversible pulpitis and apical periodontitis were concordant with proposed recommendations. These data identify opportunities to improve prescribing and serve as a benchmark for future outpatient antimicrobial stewardship efforts. Future work should assess definitive dental treatment and populations without access to oral health care. Disclosures All Authors: No reported Disclosures.


2013 ◽  
Vol 39 (10) ◽  
pp. 1205-1217 ◽  
Author(s):  
Maximiliano Schünke Gomes ◽  
Trevor Charles Blattner ◽  
Manoel Sant'Ana Filho ◽  
Fabiana Soares Grecca ◽  
Fernando Neves Hugo ◽  
...  

2017 ◽  
Vol 44 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Pinpana Tupyota ◽  
Pattama Chailertvanitkul ◽  
Malinee Laopaiboon ◽  
Chetta Ngamjarus ◽  
Paul V. Abbott ◽  
...  

2017 ◽  
Vol 28 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Alessandro Guimarães Salles ◽  
Lívia Azeredo Alves Antunes ◽  
Patrícia Arriaga Carvalho ◽  
Erika Calvano Küchler ◽  
Leonardo Santos Antunes

Abstract Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and meta-analysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms “Periapical Periodontitis,” “Periapical Abscess,” “Polymorphism, Genetic,” and “Polymorphism, Single Nucleotide” were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.


Author(s):  
Luiz Carlos de Lima Dias-Junior ◽  
Adriana Pinto Bezerra ◽  
Daniela Peressoni Vieira Schuldt ◽  
Morgane Marion Kuntze ◽  
Graziela de Luca Canto ◽  
...  

2020 ◽  
Vol 53 (8) ◽  
pp. 1068-1083 ◽  
Author(s):  
K. P. Pinto ◽  
C. M. Ferreira ◽  
L. C. Maia ◽  
L. M. Sassone ◽  
T. K. S. Fidalgo ◽  
...  

2016 ◽  
Vol 21 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Armin Shirvani ◽  
Sayna Shamszadeh ◽  
Mohammad Jafar Eghbal ◽  
Laleh Alim Marvasti ◽  
Saeed Asgary

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