A similar pro/anti-inflammatory cytokine balance is present in the airways of competitive athletes and non-exercising asthmatics

The effects ofCrotalus durissus terrificusvenom (Cdt) were analyzed with respect to the susceptibility and the inflammatory mediators in an experimental model of severe envenomation. BALB/c female mice injected intraperitoneally presented sensibility to Cdt, with changes in specific signs, blood biochemical and inflammatory mediators. The venom induced reduction of glucose and urea levels and an increment of creatinine levels in serum from mice. Significant differences were observed in the time-course of mediator levels in sera from mice injected with Cdt. The maximum levels of IL-6, NO, IL-5, TNF, IL-4 and IL-10 were observed 15 min, 30 min, 1, 2 and 4 hours post-injection, respectively. No difference was observed for levels of IFN-γ. Taken together, these data indicate that the envenomation by Cdt is regulated both pro- and anti-inflammatory cytokine responses at time-dependent manner. In serum from mice injected with Cdt at the two first hours revealed of pro-inflammatory dominance. However, with an increment of time an increase of anti-inflammatory cytokines was observed and the balance toward to anti-inflammatory dominance. In conclusion, the observation that Cdt affects the production of pro- and anti-inflammatory cytokines provides further evidence for the role played by Cdt in modulating pro/anti-inflammatory cytokine balance.

Download Full-text

Proinflammatory and Anti-Inflammatory Cytokine Balance in Gasoline Exhaust Induced Pulmonary Injury in Mice

Inhalation Toxicology ◽

10.1080/08958370590904616 ◽

2005 ◽

Vol 17 (3) ◽

pp. 161-168 ◽

Cited By ~ 12

Author(s):

Veerapandian Sureshkumar ◽

Bholanath Paul ◽

Mani Uthirappan ◽

Renu Pandey ◽

Anand Prakash Sahu ◽

...

Keyword(s):

Inflammatory Cytokine ◽

Pulmonary Injury ◽

Cytokine Balance ◽

Anti Inflammatory ◽

Anti Inflammatory Cytokine

Download Full-text

Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms and the pro-/anti-inflammatory cytokine balance

European Neuropsychopharmacology ◽

10.1016/s0924-977x(00)80278-3 ◽

2000 ◽

Vol 10 ◽

pp. 278-279

Author(s):

J.P. Kelly ◽

T.J. Connor ◽

Y. Nolan ◽

Y. Shen ◽

B.E. Leonard

Keyword(s):

Differential Effect ◽

Inflammatory Cytokine ◽

Behavioural Symptoms ◽

Antidepressant Treatments ◽

Cytokine Balance ◽

Anti Inflammatory ◽

Anti Inflammatory Cytokine

Download Full-text

Modulation of the pro- and anti-inflammatory cytokine balance by amphotericin B

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/42.4.469 ◽

1998 ◽

Vol 42 (4) ◽

pp. 469-474 ◽

Cited By ~ 21

Author(s):

A. G. Vonk ◽

M. G. Netea ◽

N. E. Denecker ◽

I. C. Verschueren ◽

J. W. van der Meer ◽

...

Keyword(s):

Amphotericin B ◽

Inflammatory Cytokine ◽

Cytokine Balance ◽

Anti Inflammatory ◽

Anti Inflammatory Cytokine

Download Full-text

Cytokine profiles in highly active antiretroviral treatment non-adherent, adherent and naive HIV-1 infected patients in Western Kenya

African Health Sciences ◽

10.4314/ahs.v21i4.12 ◽

2021 ◽

Vol 21 (4) ◽

pp. 1584-92

Author(s):

Fauzia Musa ◽

Nathan Shaviya ◽

Fidelis Mambo ◽

Collins Abonyo ◽

Erick Barasa ◽

...

Keyword(s):

Inflammatory Cytokine ◽

Antiretroviral Treatment ◽

Healthy Controls ◽

Highly Active ◽

Cytokine Balance ◽

Tnf Α ◽

Cytokine Levels ◽

Anti Inflammatory ◽

Anti Inflammatory Cytokine ◽

Hiv 1

Background: Cytokines play an important role in signaling the immune system to build an adequate immune responseagainst HIV. HIV distorts the balance between pro and anti-inflammatory cytokines causing viral replication. Highly active antiretroviral treatment (HAART) acts by trying to restore pro and anti-inflammatory cytokine balance. It is not clear how HAART non-adherence influences circulating cytokine levels. This study therefore determined cytokine levels in HAART non-adherent individuals. Methods: This cross-sectional study recruited 163 participants (51 controls, 23 HIV-1+ HAART naive, 28 HAART-adherent6 months, 19 HAART-adherent 12 months and 42 HAART non-adherent). Cytokines were analyzed by ELISA while CD4 T cells determined in 3.0 μl of whole blood using BD FACSCaliburTM and viral load in 0.2ml plasma sample using Abbott Molecular m2000sp sample preparation and m2000rt real-time amplification and detection systems (Abbott MolecularInc., Illinois, USA) according to the manufacturer’s methods. Results: IL-4, IL-6, IL-10, TNF-α and TGF-β were significantly elevated in HIV-1 HAART non-adherent compared withHIV-1 HAART adherent and healthy controls P<0.01. IFN- γ was significantly decreased in HIV-1 HAART non-adherentcompared with HIV-1 HAART adherent and healthy controls P<0.01. TNF-α and TGF-β were significantly reduced in HIV-1 HAART adherent patients at 12 months compared to those at 6 months P<0.01. IL-4 and IL-10 correlated positively withviral load. IL-4, IL-6, IL-10, TNF-α and TGF- β associated inversely with CD4 T cell counts and body mass index (BMI). Conclusion: This study established that HAART adherence is immunologically beneficial to the pro and anti-inflammatory cytokine balance milieu while non-adherence appears to cause alterations in pro and anti-inflammatory cytokines warping the balance in this dichotomy. Keywords: Cytokines; non-adherence; HAART.

Download Full-text