Risk Factors for Nosocomial Methicillin Resistant Staphylococcus aureus (MRSA) Colonization in a Neonatal Intensive Care Unit: A Case-Control Study

2021 ◽  
Author(s):  
Archana Balamohan ◽  
Joanna Beachy ◽  
Nina Kohn ◽  
Lorry G. Rubin
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Case Control Study ◽  
Case Control ◽  
Mrsa Colonization ◽  
Control Study

Risk Factors for Staphylococcus aureus Acquisition in the Neonatal Intensive Care Unit: A Matched Case-Case-Control Study

2017 ◽  
Vol 39 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Matthew C. Washam ◽  
Andrea Ankrum ◽  
Beth E. Haberman ◽  
Mary Allen Staat ◽  
David B. Haslam
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Case Control Study ◽  
Case Control ◽  
Entire Cohort ◽  
Matched Case ◽  
Control Study

OBJECTIVETo determine risk factors independent of length of stay (LOS) for Staphylococcus aureus acquisition in infants admitted to the neonatal intensive care unit (NICU).DESIGNRetrospective matched case–case-control study.SETTINGQuaternary-care referral NICU at a large academic children’s hospital.METHODSInfants admitted between January 2014 and March 2016 at a level IV NICU who acquired methicillin resistant (MRSA) or susceptible (MSSA) S. aureus were matched with controls by duration of exposure to determine risk factors for acquisition. A secondary post hoc analysis was performed on the entire cohort of at-risk infants for risk factors identified in the primary analysis to further quantify risk.RESULTSIn total, 1,751 infants were admitted during the study period with 199 infants identified as having S. aureus prevalent on admission. There were 246 incident S. aureus acquisitions in the remaining at-risk infant cohort. On matched analysis, infants housed in a single-bed unit were associated with a significantly decreased risk of both MRSA (P=.03) and MSSA (P=.01) acquisition compared with infants housed in multibed pods. Across the entire cohort, pooled S. aureus acquisition was significantly lower in infants housed in single-bed units (hazard ratio,=0.46; confidence interval, 0.34–0.62).CONCLUSIONSNICU bed design is significantly associated with S. aureus acquisition in hospitalized infants independent of LOS.Infect Control Hosp Epidemiol 2018;39:46–52

scholarly journals 1176 RISK FACTORS FOR CANDIDEMIA IN THE NEONATAL INTENSIVE CARE UNIT (NICU): A CASE-CONTROL STUDY

1985 ◽  
Vol 19 (4) ◽  
pp. 306A-306A
Author(s):  
Debra E Weese-Mayer ◽  
Diane Wheeler Fondriest ◽  
Robert T Brouillette ◽  
Stanford T Shulman
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Bacteremia Due to Persistent Strains of Coagulase-Negative Staphylococci in a Neonatal Intensive-Care Unit

1999 ◽  
Vol 20 (05) ◽  
pp. 349-351 ◽  
Author(s):  
Lillian Sung ◽  
Karam Ramotar ◽  
Lindy M. Samson ◽  
Baldwin Toye
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Coagulase Negative Staphylococci ◽  
Control Study

AbstractThis retrospective case-control study was performed to determine risk factors for bacteremia due to persistent coagulase-negative staphylococci in our neonatal intensive-care unit. Enteral nutrition and the presence of a nasogastric tube were identified as possible risk factors for coagulase-negative staphylococcal bacteremia involving one of the persistent strains.

scholarly journals RISK FACTORS FOR CANDIDEMIA IN A NEONATAL INTENSIVE CARE UNIT: A CASE-CONTROL STUDY 1328

1997 ◽  
Vol 41 ◽  
pp. 224-224
Author(s):  
Luís Eduardo Vaz Miranda ◽  
Márcio Nucci ◽  
Samura Maura Barreto E Silva ◽  
Lúcia de Fátima Guimarães ◽  
Simone Xavier
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Risk Factors and Outcomes of Methicillin-resistant Staphylococcus Aureus Bacteraemia in Critically Ill Patients: A Case Control Study

2009 ◽  
Vol 37 (3) ◽  
pp. 457-463 ◽  
Author(s):  
K. M. Ho ◽  
J. O. Robinson
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Critically Ill Patients ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Case Control Study ◽  
Case Control ◽  
Mrsa Infection ◽  
Control Study

Methicillin-resistant Staphylococcus aureus (MRSA) infection is an increasing threat to critically ill patients in many intensive care units. MRSA bacteraemia is an extreme form of MRSA infection and is a significant cause of morbidity and mortality. This case control study aimed to assess the risk factors and outcomes of MRSA bacteraemia compared to methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. A total of 21 MRSA bacteraemia and 60 randomly selected MSSA bacteraemia episodes, admitted to the intensive care unit at Royal Perth Hospital between 1997 and 2007, were considered. There was a suggestion that hospitalisation within the preceding six months (P=0.087) and residence in a long-term care facility (P=0.065) were associated with a higher risk of MRSA bacteraemia. MRSA bacteraemia was more often treated with antibiotics to which the pathogen was not susceptible in vitro (38.1% vs 0%, P=0.001), resulting in a longer duration of fever (median 7.0 vs 2.0 days, P=0.009) and bacteraemia (mean 3.2 vs 0.6 days, P=0.005) and a higher incidence of metastatic seeding of infection (52.4% vs 21.7%, P=0.012) as compared to MSSA bacteraemia. While in-hospital mortality between MRSA and MSSA was similarly high (47.6% vs 38.3% for MRSA and MSSA respectively, P=0.607), a significant proportion of the patients who had MRSA bacteraemia died within five years of hospital discharge (36.4%, hazard ratio 26.0, 95% confidence interval 1.90 to 356.7, P=0.015). Infections contributed to 75% of the deaths after hospital discharge in patients who had an episode of MRSA bacteraemia. MRSA bacteraemia carries a much worse long-term prognosis than MSSA bacteraemia and that could be explained by recurrent MRSA infections and residual confounding.

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