Performance- and cost-benefit analysis of an influenza point-of-care test compared to laboratory-based multiplex RT-PCR in the emergency department

2021 ◽  
Author(s):  
Myrte van der Kraan ◽  
Elke L. Hobbelink ◽  
Jayant Kalpoe ◽  
Sjoerd M. Euser ◽  
Dominic Snijders ◽  
...  
Keyword(s):  
Emergency Department ◽  
Cost Benefit Analysis ◽  
Point Of Care ◽  
Cost Benefit ◽  
Benefit Analysis ◽  
Rt Pcr ◽  
Point Of Care Test

Pharmaceutical interventions in the emergency department: cost-effectiveness and cost-benefit analysis

2020 ◽  
pp. ejhpharm-2019-002067
Author(s):  
Marta Miarons ◽  
Sergio Marín ◽  
Imma Amenós ◽  
Lluis Campins ◽  
Montse Rovira ◽  
...  
Keyword(s):  
Emergency Department ◽  
Cost Effectiveness ◽  
Cost Benefit Analysis ◽  
Cost Benefit ◽  
Benefit Analysis ◽  
Pharmaceutical Interventions

scholarly journals Prospective evaluation of ID NOW COVID-19 assay used as point-of-care test in an Emergency Department

2021 ◽  
Author(s):  
Jean-Claude Nguyen Van ◽  
Camille Gerlier ◽  
Benoit Pilmis ◽  
Assaf Mizrahi ◽  
Gauthier Pean de Ponfilly ◽  
...  
Keyword(s):  
Emergency Department ◽  
Point Of Care ◽  
False Negative ◽  
Study Participant ◽  
Reference Method ◽  
Rt Pcr ◽  
Point Of Care Test ◽  
Viral Transport Medium ◽  
Sensitivity Specificity ◽  
User Friendly

Background : Rapid testing for COVID-19 has been clearly identified as an essential component of the strategy to control the SARS-CoV-2 epidemic, worldwide. The ID NOW COVID-19 assay is a simple, user-friendly, rapid molecular biology test based on nicking and extension amplification reaction (NEAR). Objectives : The aim of this study was to evaluate the ID NOW COVID-19 assay when used as a point-of-care test (POCT) in our Emergency Department (ED). Type of study : This prospective study enrolled 395 consecutive patients; paired nasopharyngeal swabs were collected from each study participant. The first swab was tested with the ID NOW COVID-19 assay at the point-of-care by ED nurses. The second swab was diluted in viral transport medium (VTM) and sent to the clinical microbiology department for analysis by both the RT-PCR Simplexa test COVID-19 Direct assay as the study reference method, and the ID NOW COVID-19 assay performed in the laboratory. Results : Nasopharyngeal swabs directly tested with the ID NOW COVID-19 assay yielded a sensitivity, specificity, PPV and NPV of 98.0%, 97.5%, 96.2% and 98.7%, respectively, in comparison with the RT-PCR study reference assay. When the ID NOW COVID-19 assay was performed in the laboratory using the VTM samples, the sensitivity decreased to 62.5% and the NPV to 79.7%. Three false negative test results were reported with the ID NOW COVID-19 assay when performed using undiluted swabs directly in the ED; these results were obtained from patients with elevated CT values (>30). Conclusion : We demonstrated that the ID NOW COVID-19 assay, performed as a point of care test in the ED using dry swabs, provides a rapid and reliable alternative to laboratory-based RT-PCR methods

Sign in / Sign up

Export Citation Format

Share Document