The Risk of Primary Open-Angle Glaucoma Following Vitreoretinal Surgery—A Population-based Study

Abstract Background: To compare plasma fatty acids (FAs) between participants with primary open-angle glaucoma (POAG) and participants without neuropathy in an elderly population and to investigate specific FAs pattern in POAG.Methods: We conducted a population-based study in participants older than 75 years. Participants underwent a comprehensive eye examination with optic nerve photographs, visual field test and optic nerve OCT with RNFL thickness measurement. Glaucomatous status was defined according to the International Society for Epidemiologic and Geographical Ophthalmology classification. Lipids were extracted from plasma and FAs methylesters prepared and analyzed by gas chromatography-mass spectrometry. Results: Among the 1153 participants of the Montrachet study 810 were retained for analysis and 68 had POAG. The mean age was 82.11 ± 3.67. In multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern characterized by high negative weight of gamma-linoleic acid, eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive weight of eicosadienoic acid, docosatetraenoic acid, docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid MUFAs, margaric acid and behenic acid saturated FAs was positively associated with POAG. After adjustment for major confounders, individuals in the upper tertile of FAs pattern scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29 - 7.40] P = 0.013).Conclusions: We found no significant difference regarding isolated plasma FAs between participants with POAG and participants without neuropathy in elderly but specific FAs pattern might be associated with POAG.

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Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

BMC Ophthalmology ◽

10.1186/s12886-021-01910-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Alicia Chemaly ◽

Louis Arnould ◽

Alassane Seydou ◽

Pierre-Henry Gabrielle ◽

Florian Baudin ◽

...

Keyword(s):

Fatty Acids ◽

Linoleic Acid ◽

Optic Nerve ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Population Based ◽

Open Angle ◽

Population Based Study ◽

Plasma Fatty Acids ◽

Significant Difference

Abstract Background To compare plasma fatty acids (FAs) between participants with primary open-angle glaucoma (POAG) and participants without neuropathy in an elderly population and to investigate specific FAs pattern in POAG. Methods We conducted a population-based study in participants older than 75 years. Participants underwent a comprehensive eye examination with optic nerve photographs, visual field test and optic nerve OCT with RNFL thickness measurement. Glaucomatous status was defined according to the International Society for Epidemiologic and Geographical Ophthalmology classification. Lipids were extracted from plasma and FAs methylesters prepared and analyzed by gas chromatography-mass spectrometry. Results Among the 1153 participants of the Montrachet study 810 were retained for analysis and 68 had POAG. The mean age was 82.11 ± 3.67. In multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern characterized by high negative weight of gamma-linoleic acid, eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive weight of eicosadienoic acid, docosatetraenoic acid, docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid MUFAs, margaric acid and behenic acid saturated FAs was positively associated with POAG. After adjustment for major confounders, individuals in the upper tertile of FAs pattern scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29–7.40] P = 0.013). Conclusions We found no significant difference regarding isolated plasma FAs between participants with POAG and participants without neuropathy in elderly but specific FAs pattern might be associated with POAG.

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Faculty Opinions recommendation of Association of Systemic Hypertension with Primary Open-Angle Glaucoma: A Population-Based Case-control Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737870317.793575777 ◽

2020 ◽

Author(s):

Alon Harris ◽

Alice Verticchio ◽

Brent Siesky

Keyword(s):

Case Control Study ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Population Based ◽

Case Control ◽

Systemic Hypertension ◽

Open Angle ◽

Control Study

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Albuminuria and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study (SCES)

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-315920 ◽

2020 ◽

pp. bjophthalmol-2020-315920 ◽

Cited By ~ 1

Author(s):

Zhi Wei Lim ◽

Miao-Li Chee ◽

Sahil Thakur ◽

Xiaoling Fang ◽

Zhi Da Soh ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Smoking Status ◽

Open Angle Glaucoma ◽

Estimating Equation ◽

Population Based ◽

Urinary Albumin ◽

Open Angle ◽

Chinese Adults ◽

Medication History ◽

Singapore Chinese

AimsTo determine the association between albuminuria and primary open-angle glaucoma (POAG).MethodsParticipants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on random spot urinary albumin and creatinine measurements. POAG was defined using the International Society of Geographic and Epidemiological Ophthalmology classification. Multivariable logistic regression with generalised estimating equation model was used to evaluate the association between albuminuria and POAG, while accounting for correlation between eyes.ResultsA total of 3009 Chinese adults (5963 eyes), aged 40–80 years, were included in this study, of which, 52 subjects (75 eyes) had POAG. Higher UACR (per 50 mg/g increase) was independently associated with POAG (OR=1.04, 95% CI 1.01 to 1.07, p=0.003) following adjustment for age, gender, intraocular pressure, diabetes mellitus, hyperlipidaemia, hypertension, anti-hypertensive medication, history of cardiovascular disease, current smoking status, alcohol intake, body mass index and estimated glomerular filtration rate. Further stratification revealed that individuals with macroalbuminuria were 8.00 times likely to have POAG (95% CI 2.97 to 21.54, p<0.001), compared with those with normoalbuminuria. Microalbuminuria was not significantly associated with POAG (OR=0.49, 95% CI 0.19 to 1.29, p=0.150). The association between macroalbuminuria and POAG remained significant among individuals who were diabetic (OR=9.89, 95% CI 2.49 to 39.30, p=0.001) and hypertensive (OR=8.39, 95% CI 3.07 to 22.94, p<0.001).ConclusionIn this population-based study of Chinese adults, albuminuria was independently associated with POAG. Our findings provide further understanding on the pathogenesis of POAG and may potentially help to better identify individuals at risk of POAG.

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