OCT Measurements of the Retinal Pigment Epithelium to Bruch's Membrane Thickness around Geographic Atrophy Correlate with Growth

2021 ◽  
Author(s):  
Zhongdi Chu ◽  
Yingying Shi ◽  
Xiao Zhou ◽  
Liang Wang ◽  
Hao Zhou ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Geographic Atrophy ◽  
Membrane Thickness ◽  
Bruch's Membrane ◽  
Bruch’S Membrane

scholarly journals Utilizing Recombinant Spider Silk Proteins To Develop a Synthetic Bruch’s Membrane for Modeling the Retinal Pigment Epithelium

2019 ◽  
Vol 5 (8) ◽  
pp. 4023-4036 ◽  
Author(s):  
Thomas I. Harris ◽  
Chase A. Paterson ◽  
Farhad Farjood ◽  
Ian D. Wadsworth ◽  
Lori Caldwell ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Spider Silk ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Silk Proteins

Retinal Pigment Epithelium Wound Healing in Human Bruch’s Membrane Explants

2003 ◽  
Vol 44 (5) ◽  
pp. 2199 ◽  
Author(s):  
Hao Wang ◽  
Yoshihiko Ninomiya ◽  
Ilene K. Sugino ◽  
Marco A. Zarbin
Keyword(s):  
Wound Healing ◽  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Bruch's Membrane ◽  
Bruch’S Membrane

Bruch’s membrane pathology: A mechanistic perspective

2020 ◽  
Vol 30 (6) ◽  
pp. 1195-1206 ◽  
Author(s):  
Aishwarya Murali ◽  
Subramanian Krishnakumar ◽  
Anuradha Subramanian ◽  
Sowmya Parameswaran
Keyword(s):  
Extracellular Matrix ◽  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Vital Role ◽  
Age Related Macular Degeneration ◽  
Ocular Diseases ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Age Related

Bruch’s membrane, an extracellular matrix located between the retinal pigment epithelium and the choroid, plays a vital role as structural and functional support to the retinal pigment epithelium. Dysfunction of Bruch’s membrane in both age-related macular degeneration and other ocular diseases is caused mostly by extracellular matrix degeneration, deposit formation, and angiogenesis. Although these factors are dealt in greater detail with respect to the cells that are degenerated such as the retinal pigment epithelium and the endothelial cells, the pathology involving the Bruch’s membrane is often underrated. Since in most of the macular degenerations early degenerative changes are also observed in the Bruch’s membrane, addressing only the cellular component without the underlying membrane will not yield an ideal clinical benefit. This review aims to discuss the factors and the mechanisms affecting the integrity of the Bruch’s membrane, which would aid in developing an effective therapy for these pathologies.

Sign in / Sign up

Export Citation Format

Share Document