Correlation of Change in Central Subfield Thickness and Change in Visual Acuity in Neovascular AMD: Post Hoc Analysis of VIEW 1 and 2

Purpose: The aim was to describe baseline characteristics of the fellow eye of patients with neovascular age-related macular degeneration (nAMD). Methods: A pooled, post hoc analysis of patients with nAMD enrolled in the VIEW studies was carried out. The VIEW studies compared intravitreal aflibercept (monthly or every 2 months after 3 monthly injections) with monthly ranibizumab. Baseline choroidal neovascularization (CNV) status of fellow eyes and baseline best-corrected visual acuity (BCVA) and lens status of all eyes were evaluated. Additional analyses evaluated the presence of drusen and pigment in fellow eyes. Results: When comparing both eyes, baseline BCVA was worse in 23.8% of fellow eyes and in 75.2% of study eyes. Lens status of fellow eyes and study eyes was similar. Baseline visual acuity of the study eye and that of the fellow eye were not correlated. Most fellow eyes had signs of early AMD, with 34.6% (n = 843) of fellow eyes having evidence of scarring. Conclusions: In patients in the VIEW studies, most fellow eyes had evidence of AMD, highlighting the importance of examining both eyes, with close follow-up thereafter, in order to detect and treat CNV earlier as needed.

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Relationship between duration and extent of oedema and visual acuity outcome with ranibizumab in diabetic macular oedema: A post hoc analysis of Protocol I data

Eye ◽

10.1038/s41433-019-0522-z ◽

2019 ◽

Vol 34 (3) ◽

pp. 480-490 ◽

Cited By ~ 5

Author(s):

Srinivas R. Sadda ◽

Joanna Campbell ◽

Pravin U. Dugel ◽

Nancy M. Holekamp ◽

Szilárd Kiss ◽

...

Keyword(s):

Visual Acuity ◽

Macular Oedema ◽

Diabetic Macular Oedema ◽

Post Hoc Analysis ◽

Post Hoc

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Effect of fluocinolone acetonide 0.2 μg/day implant on the decision to drive in patients with diabetic macular oedema: a report from the FAME study

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2019-000405 ◽

2019 ◽

Vol 4 (1) ◽

pp. e000405 ◽

Cited By ~ 1

Author(s):

Dilraj S Grewal ◽

Donald C Fletcher ◽

Seenu M Hariprasad ◽

Ivan J Suner

Keyword(s):

Macular Oedema ◽

Diabetic Macular Oedema ◽

Fluocinolone Acetonide ◽

Phase Iii ◽

Full Cohort ◽

Post Hoc Analysis ◽

Corrected Visual Acuity ◽

Central Subfield Thickness ◽

Post Hoc

ObjectiveThis study aimed to determine whether treatment with the 0.2 µg/day fluocinolone acetone implant (FAc; ILUVIEN, Alimera Sciences) and the associated improvements in best-corrected visual acuity (BCVA) and central subfield thickness (CST) demonstrated in the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) study have an impact on the patient’s decision to drive as measured by the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25).MethodsThis was a post hoc analysis of up to 3 years of NEI-VFQ-25 data collected during the phase III FAME trial. Patients were divided into four quartiles according to baseline NEI-VFQ-25 driving subscale (DSS) score. Patients who had never driven were excluded. Patients received either the 0.2 µg/day FAc implant or sham (dummy injection). Change in the DSS score of the NEI-VFQ-25 questionnaire over 3 years in FAc-treated versus sham-treated patients was analysed by BCVA, CST and baseline DSS score.ResultsThe proportion of patients achieving BCVA≥20/40 was similar between the FAc and sham groups throughout the study, while improvements in CST were significantly greater in the quartile of FAc-treated patients with the lowest baseline DSS score (quartile 1; p=0.04). Significant improvements in DSS score were also observed in quartile 1 (p=0.024), while numerical—but not significant—improvements in DSS score were observed in the full cohort.ConclusionThis post hoc analysis demonstrates a significant association between clinical outcomes in diabetic macular oedema and improvement in quality of life measures following a single FAc implant.

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Abstract #295 GLP-1 Receptor Agonists and Death From Any Cause in Elderly Patients with Type 2 Diabetes Mellitus: A Post-Hoc Analysis

Endocrine Practice ◽

10.1016/s1530-891x(20)47140-x ◽

2018 ◽

Vol 24 ◽

pp. 80-81

Author(s):

Konstantinos Toulis ◽

Krishna Gokhale ◽

G. Neil Thomas ◽

Wasim Hanif ◽

Krishnarajah Nirantharakumar ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Elderly Patients ◽

Post Hoc Analysis ◽

Receptor Agonists ◽

Post Hoc

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Abstract #245 Efficacy and Safety of Semaglutide in Elderly Subjects with Type 2 Diabetes: A Post Hoc Analysis of the Sustain 7 Trial

Endocrine Practice ◽

10.1016/s1530-891x(20)47090-9 ◽

2018 ◽

Vol 24 ◽

pp. 51-52

Author(s):

Vanita Aroda ◽

Danny Sugimoto ◽

David Trachtenbarg ◽

Mark Warren ◽

Gurudutt Nayak ◽

...

Keyword(s):

Type 2 Diabetes ◽

Elderly Subjects ◽

Efficacy And Safety ◽

Post Hoc Analysis ◽

Post Hoc

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Response-Specific Scalp Distributions in Deception Detection and ERP Correlates of Psychopathic Personality Traits

Journal of Psychophysiology ◽

10.1027/0269-8803.18.1.13 ◽

2004 ◽

Vol 18 (1) ◽

pp. 13-26 ◽

Cited By ~ 13

Author(s):

Antoinette R. Miller ◽

J. Peter Rosenfeld

Keyword(s):

Deception Detection ◽

Event Related Potential ◽

Psychopathic Personality ◽

P300 Amplitude ◽

Group Differences ◽

Post Hoc Analysis ◽

P300 Component ◽

Psychopathic Personality Inventory ◽

Post Hoc ◽

First Time

Abstract University students were screened using items from the Psychopathic Personality Inventory and divided into high (n = 13) and low (n = 11) Psychopathic Personality Trait (PPT) groups. The P300 component of the event-related potential (ERP) was recorded as each group completed a two-block autobiographical oddball task, responding honestly during the first (Phone) block, in which oddball items were participants' home phone numbers, and then feigning amnesia in response to approximately 50% of items in the second (Birthday) block in which oddball items were participants' birthdates. Bootstrapping of peak-to-peak amplitudes correctly identified 100% of low PPT and 92% of high PPT participants as having intact recognition. Both groups demonstrated malingering-related P300 amplitude reduction. For the first time, P300 amplitude and topography differences were observed between honest and deceptive responses to Birthday items. No main between-group P300 effects resulted. Post-hoc analysis revealed between-group differences in a frontally located post-P300 component. Honest responses were associated with late frontal amplitudes larger than deceptive responses at frontal sites in the low PPT group only.

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