228: Secretory leukocyte protease inhibitor and neutrophil elastase in the cervical mucus with short cervical length

2015 ◽  
Vol 212 (1) ◽  
pp. S127
Author(s):  
Sooran Choi
Keyword(s):  
Protease Inhibitor ◽  
Neutrophil Elastase ◽  
Cervical Length ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Cervical Mucus

Neutrophil elastase increases secretory leukocyte protease inhibitor transcript levels in airway epithelial cells

1993 ◽  
Vol 265 (3) ◽  
pp. L286-L292 ◽  
Author(s):  
J. M. Abbinante-Nissen ◽  
L. G. Simpson ◽  
G. D. Leikauf
Keyword(s):  
Epithelial Cells ◽  
Protease Inhibitor ◽  
Neutrophil Elastase ◽  
Airway Epithelial Cells ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Cathepsin G ◽  
Dependent Manner ◽  
Airway Epithelial ◽  
Necrosis Factor Alpha ◽  
Transcript Levels

Airway inflammation is often associated with the infiltration of activated neutrophils and subsequent protease release. Although aiding in the digestion and phagocytosis of foreign proteins and microorganisms, neutrophil proteases can indiscriminately damage healthy lung tissue. In the conducting airway, proteases, particularly neutrophil elastase, are counter-balanced by several antiproteases, including secretory leukocyte protease inhibitor (SLPI). SLPI can be produced locally by a number of cells including the airway epithelial cell. To examine the effects of neutrophil granule components on SLPI transcript levels, airway epithelial cells were treated (up to 96 h) with elastase, other proteases, or enzymes isolated from human sputum. We found that neutrophil elastase increased SLPI transcript levels in primary and transformed human airway epithelial cells in a time- and dose-dependent manner. Other neutrophil products, such as cathepsin G, myeloperoxidase, and lysozyme, had little or no effect on SLPI transcript levels. However, two nonneutrophil proteases, trypsin and pancreatic elastase, also increased SLPI transcript levels at higher doses than that required of neutrophil elastase. Two inflammatory cytokines, tumor necrosis factor-alpha and interleukin-8, produced little or no effect on SLPI transcript levels. This study demonstrates one way in which SLPI is regulated, via a protease that it inhibits, neutrophil elastase.

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1239-1249 ◽  
Author(s):  
Olga Klimenkova ◽  
Wienke Ellerbeck ◽  
Maksim Klimiankou ◽  
Murat Ünalan ◽  
Siarhei Kandabarau ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Neutrophil Elastase ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Myeloid Differentiation ◽  
Severe Congenital Neutropenia ◽  
Granulocytic Differentiation ◽  
Congenital Neutropenia ◽  
Key Points ◽  
Natural Inhibitor

Key Points The natural inhibitor of neutrophil elastase, SLPI, is severely reduced in severe congenital neutropenia patients. SLPI controls myeloid differentiation by regulation of NFκB, ERK1/2:LEF-1, and c-myc activation.

Elevated concentration of secretory leukocyte protease inhibitor in the cervical mucus before delivery

2016 ◽  
Vol 214 (6) ◽  
pp. 741.e1-741.e7 ◽  
Author(s):  
Taiki Samejima ◽  
Takeshi Nagamatsu ◽  
Danny J. Schust ◽  
Nao Itaoka ◽  
Takayuki Iriyama ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Cervical Mucus ◽  
Elevated Concentration

Evaluation of the levels of secretory leukocyte protease inhibitor in the cervical mucus of women with unexplained infertility

2020 ◽  
Vol 46 (7) ◽  
pp. 1128-1132
Author(s):  
Ilknur Col Madendag ◽  
Mefkure Eraslan Sahin ◽  
Yusuf Madendag ◽  
Erdem Sahin ◽  
Cigdem Karakukcu
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Unexplained Infertility ◽  
Cervical Mucus
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