544: The relationship between body mass index, cervical length and spontaneous preterm birth

AbstractThe aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-α), and spontaneous preterm birth (SPTB) up to 14 days from sampling.Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF-α. The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission.Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman’s coefficient R=–0.382, P<0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5±4.63 mm, which is significantly lower than patients with a negative test –23.43±7.39 mm (P=0.003).The studied biochemical markers were only moderately successful in the prediction of preterm delivery.

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The relationship between maternal age, body mass index and the rate of preterm birth

Journal of the Turkish-German Gynecological Association ◽

10.4274/jtgga.2018.0057 ◽

2018 ◽

Author(s):

Joachim W. Dudenhausen ◽

Mirjam Kunze ◽

Ursula Wittwer-Backofe ◽

Hans Peter Hagenah ◽

Alexander Strauss ◽

...

Keyword(s):

Body Mass Index ◽

Preterm Birth ◽

Body Mass ◽

Maternal Age ◽

The Relationship

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520: Severe and moderate thinness (prepregnancy body mass index <17) as risk factors for spontaneous preterm birth

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2012.10.686 ◽

2013 ◽

Vol 208 (1) ◽

pp. S223-S224

Author(s):

Ogechi Agwu ◽

Jan Hart ◽

Barbra Fisher ◽

Nancy West ◽

Ronald Gibbs ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Preterm Birth ◽

Body Mass ◽

Spontaneous Preterm Birth ◽

Prepregnancy Body Mass Index

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Smoking and other pre-gestational risk factors for spontaneous preterm birth

Revista Brasileira de Saúde Materno Infantil ◽

10.1590/s1519-38292011000400006 ◽

2011 ◽

Vol 11 (4) ◽

pp. 397-403 ◽

Cited By ~ 3

Author(s):

Eugênio Grillo ◽

Paulo Fontoura Freitas

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Preterm Birth ◽

Body Mass ◽

Gestational Age ◽

Maternal Age ◽

Preterm Births ◽

Cumulative Effects ◽

Independent Effect ◽

Spontaneous Preterm Birth

OBJECTIVES: to investigate pre-gestational risk factors for spontaneous preterm birth and, the role of smoking and its cumulative effects on prematurity. METHODS: a case-control study analyzed a data set of all births occurring in a tertiary maternity hospital between April 2002 and July 2004. Spontaneous preterm births of single and live newborns without malformations were selected as cases. Controls were all the term births of live and single newborns without malformations during the same period. Three outcomes were studied: all preterm births (<37 weeks), less than 35 weeks and less than 32 weeks of gestational age. Logistic regression was used to obtain the independent effect of pre-gestational risk factors. RESULTS: maternal age of less than 20 years, low schooling, low maternal pre-gestational body mass index and smoking showed significant, independent association with spontaneous preterm birth for the three outcomes. For all these risk factors, excepting maternal smoking, odds ratios increased with decreasing gestational age at birth and this trend was significant for low maternal age and low pre-gestational body mass index. CONCLUSIONS: the cumulative effects of smoking calls for the need to encourage smoking cessation among pregnant women, especially those who are underweight and in the older age groups, because of the increased risk of delivering premature babies.

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