scholarly journals HELLP Syndrome is Characterized by a Unique Pattern of Complement Protein Biomarkers

2022 ◽  
Vol 226 (1) ◽  
pp. S484-S485
Author(s):  
Richard M. Burwick ◽  
Anuja Java ◽  
Kathryn J. Gray ◽  
David Combs ◽  
Monica Rincon ◽  
...  
Keyword(s):  
Hellp Syndrome ◽  
Complement Protein ◽  
Protein Biomarkers ◽  
Unique Pattern

scholarly journals Eculizumab, a novel potential treatment for acute kidney injury associated with preeclampsia/HELLP syndrome

2019 ◽  
Vol 12 (9) ◽  
pp. e228709 ◽  
Author(s):  
Hatem Elabd ◽  
Mennallah Elkholi ◽  
Lewis Steinberg ◽  
Anjali Acharya
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Complement Activation ◽  
Hellp Syndrome ◽  
Kidney Injury ◽  
Complement Protein ◽  
Igg Antibody ◽  
Elevated Liver Enzymes

The kidney is one of the major organs affected in preeclampsia. There is evidence suggesting a role for excessive complement activation in the pathogenesis of preeclampsia. We describe a case of preeclampsia with severe features, including HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and acute kidney injury (AKI) that developed following caesarian section. The patient required renal replacement therapy. A trial of daily plasma exchange was not effective. The patient received a single dose of eculizumab, a humanised monoclonal IgG antibody that binds to complement protein C5. One week post administration of eculizumab, there was significant improvement in haematologic, hepatic and renal function. Blood pressure had normalised and renal replacement therapy was discontinued. The use of eculizumab may have contributed to recovery of kidney function further supporting the role of complement activation in the pathogenesis of preeclampsia and associated AKI.

Maternal and fetal outcome in HELLP syndrome

2019 ◽  
Vol 3 (4) ◽  
pp. 140-144
Author(s):  
Badugu Rao Bahadur ◽  
Prabha Devi Kodey ◽  
Amrutha Mula
Keyword(s):  
Hellp Syndrome ◽  
Fetal Outcome

Early-Onset Preeclampsia with Pulmonary Edema and Massive Ascites: A Rare Presentation of Severe Preeclampsia or Concomitant Diagnoses?

2020 ◽  
Vol 2020 ◽  
Author(s):  
Elizabeth St. Laurent ◽  
Rebecca Fryer-Gordon ◽  
Tom McNeilis, ◽  
Leonard B. Goldstein
Keyword(s):  
Pulmonary Edema ◽  
Early Onset ◽  
Hellp Syndrome ◽  
Disease Process ◽  
Massive Ascites ◽  
Elevated Liver Enzymes ◽  
Biophysical Profile ◽  
Patient Reported ◽  
Early Onset Preeclampsia ◽  
New Onset

Preeclampsia, eclampsia, and HELLP syndrome, are a continuum of a dangerous disease process that can occur in pregnancy. Preeclampsia is defined by new onset hypertension and proteinuria. In more severe cases, preeclampsia can be associated with pulmonary edema, oliguria, persistent headaches, and impaired liver function. These symptoms reveal maternal end organ damage which may result in danger to the fetus such as oligohydramnios, decreased fetal growth, and placental abruption. The defining difference between preeclampsia and eclampsia is the presence of new onset seizure activity. HELLP syndrome occurs when the mother experiences hemolysis, elevated liver enzymes, and low platelets. This syndrome is seen in about 0.6% of pregnancies. Each of these conditions (preeclampsia, eclampsia, and HELLP) increase both the fetal and maternal morbidity and mortality rates with the most definitive cure being delivery of child and placenta.A 28 year-old Caucasian, G1P0 female at 26w4d presented to OB triage on the recommendation of her physician due to elevated uric acid levels and a recorded blood pressure of 180/110. The patient reported rapid onset of weight gain, facial edema, diminished fetal movements, and frequent headaches. Although the patient denied labor symptoms, she complained of back pain and was admitted to the hospital at 26w4d for observation due to elevated blood pressures. The patient was diagnosed with preeclampsia with severe features. As her presentation progressed, the patient developed massive ascites and pulmonary edema along with decreasing platelet counts and increasing liver enzyme values. Due to decreasing biophysical profile (BPP) scores of the fetus and decompensating lab values of the mother, an emergency cesarean was performed for the safety of mother and baby.This case presentation demonstrates the progression of hypertensive disorders of pregnancy with a rare and severe presentation of early-onset preeclampsia with severe features, pulmonary edema, and massive ascites that ultimately led to class III HELLP syndrome and extreme prematurity of the infant.

A Rare Case of Expanded Dengue, Evans Syndrome, Hellp Syndrome & Multiorgan Dysfunction

2019 ◽  
Vol 10 (12) ◽  
pp. 171
Author(s):  
N. K. Sundaray ◽  
Srikant Kumar Dhar ◽  
Chandan Das ◽  
P. K. Tudu ◽  
S. C. Das ◽  
...  
Keyword(s):  
Hellp Syndrome ◽  
Rare Case ◽  
Evans Syndrome ◽  
Multiorgan Dysfunction
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