scholarly journals Childhood Neurodevelopmental outcomes of hypertensive disorders of pregnancy

2022 ◽  
Vol 226 (1) ◽  
pp. S514-S515
Author(s):  
Alan T. Tita ◽  
Katherine Grantz ◽  
William A. Grobman ◽  
Anthony Sciscione ◽  
Daniel Skupski ◽  
...  
Keyword(s):  
Hypertensive Disorders Of Pregnancy ◽  
Neurodevelopmental Outcomes ◽  
Hypertensive Disorders

A Retrospective Cohort Study on Mortality and Neurodevelopmental Outcomes of Preterm Very Low Birth Weight Infants Born to Mothers with Hypertensive Disorders of Pregnancy

2021 ◽  
Author(s):  
Yumi Kono ◽  
Naohiro Yonemoto ◽  
Hidehiko Nakanishi ◽  
Shigeharu Hosono ◽  
Shinya Hirano ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Research Network ◽  
Hypertensive Disorders Of Pregnancy ◽  
Neurodevelopmental Outcomes ◽  
Vlbw Infants ◽  
Growth Status ◽  
Intrauterine Growth ◽  
Hypertensive Disorders

Objective We examined the effects of maternal hypertensive disorders of pregnancy (HDP) on the mortality and neurodevelopmental outcomes in preterm very low birth weight (VLBW) infants (BW ≤1,500 g) based on their intrauterine growth status and gestational age (GA). Study Design We included singleton VLBW infants born at <32 weeks' gestation registered in the Neonatal Research Network Japan database. The composite outcomes including death, cerebral palsy (CP), and developmental delay (DD) at 3 years of age were retrospectively compared among three groups: appropriate for GA (AGA) infants of mothers with and without HDP (H-AGA and N-AGA) and small for GA (SGA) infants of mothers with HDP (H-SGA). The adjusted odds ratios (AOR) and 95% confidence intervals (CI) stratified by the groups of every two gestational weeks were calculated after adjusting for the center, year of birth, sex, maternal age, maternal diabetes, antenatal steroid use, clinical chorioamnionitis, premature rupture of membranes, non-life-threatening congenital anomalies, and GA. Results Of 19,323 eligible infants, outcomes were evaluated in 10,192 infants: 683 were H-AGA, 1,719 were H-SGA, and 7,790 were N-AGA. Between H-AGA and N-AGA, no significant difference was observed in the risk for death, CP, or DD in any GA groups. H-AGA had a lower risk for death, CP, or DD than H-SGA in the 24 to 25 weeks group (AOR: 0.434, 95% CI: 0.202–0.930). The odds for death, CP, or DD of H-SGA against N-AGA were found to be higher in the 24 to 25 weeks (AOR: 2.558, 95% CI: 1.558–3.272) and 26 to 27 weeks (AOR: 1.898, 95% CI: 1.427–2.526) groups, but lower in the 30 to 31 weeks group (AOR: 0.518, 95% CI: 0.335–0.800). Conclusion There was a lack of follow-up data; however, the outcomes of liveborn preterm VLBW infants of mothers with HDP depended on their intrauterine growth status and GA at birth. Key Points

scholarly journals Health, Physical Growth, and Neurodevelopmental Outcomes in Preterm Infants of Women With Hypertensive Disorders of Pregnancy

2019 ◽  
Vol 48 (1) ◽  
pp. 69-77
Author(s):  
Forgive Avorgbedor ◽  
Susan Silva ◽  
Elizabeth Merwin ◽  
James A. Blumenthal ◽  
Diane Holditch-Davis
Keyword(s):  
Preterm Infants ◽  
Physical Growth ◽  
Hypertensive Disorders Of Pregnancy ◽  
Neurodevelopmental Outcomes ◽  
Hypertensive Disorders

Association between hypertensive disorders of pregnancy and long-term neurodevelopmental outcomes in the offspring

2021 ◽  
Author(s):  
Anna Palatnik ◽  
Brian M Casey ◽  
Michael Varner ◽  
Yoram Sorokin ◽  
Uma M. Reddy ◽  
...  
Keyword(s):  
Child Behavior Checklist ◽  
Rating Scales ◽  
Gestational Hypertension ◽  
Secondary Analysis ◽  
Language Delay ◽  
Hypertensive Disorders Of Pregnancy ◽  
Neurodevelopmental Outcomes ◽  
Thyroxine Therapy ◽  
Hypertensive Disorders

Objective: The long-term impact of hypertensive disorders of pregnancy (HDP) exposure on offspring health is an emerging research area. The objective of this study was to evaluate the association between a maternal diagnosis of HDP (gestational hypertension and preeclampsia) and adverse neurodevelopmental outcomes in the offspring. Study Design: A secondary analysis of two parallel multicenter clinical trials of thyroxine therapy for subclinical hypothyroid disorders in pregnancy. Women with singleton non-anomalous gestations diagnosed with subclinical hypothyroidism or hypothyroxinemia were randomized to thyroxine therapy or placebo. The primary outcome was child intelligence quotient (IQ) at 5 years of age. Secondary outcomes were Bayley-III cognitive, motor and language scores at 12 and 24 months, DAS-II scores at 36 months, the Conners’ Rating Scales-Revised at 48 months, and scores from the Child Behavior Checklist at 36 and 60 months. Associations between neurodevelopment outcomes and maternal HDP were examined using univariable and multivariable analyses. Results: A total of 112 woman-child dyads with HDP were compared with 1067 woman-child dyads without HDP. In univariable analysis, mean maternal age (26.7±5.9 vs. 27.8±5.7 years, p=0.032) and nulliparity (45.5% vs. 31.0%, p=0.002) differed significantly between the two groups. Maternal socioeconomic characteristics did not differ between the groups. After adjusting for potential confounders, there were no significant differences in primary or secondary neurodevelopment outcome between offspring exposed to HDP and those unexposed. However, when dichotomized as low or high scores, we found higher rates of language delay (language scores <85: -1 standard deviation) at two years of age among offspring exposed to HDP compared with those unexposed (46.5% versus 30.5%, adjusted odds ratio 2.22, 95% CI 1.44 - 3.42). Conclusions: In this cohort of pregnant women, HDP diagnosis was associated with language delay at 2 years of age. However, other long-term neurodevelopmental outcomes in offspring were not associated with HDP.

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